4DU8

Crystal structure of Staphylococcus epidermidis D283A mevalonate diphosphate decarboxylase complexed with inhibitor DPGP

Summary for 4DU8

Entry DOI	10.2210/pdb4du8/pdb
Related	3QT5 3QT6 3QT7 3QT8 4DPT 4DPU 4DPW 4DPX 4DPY 4DU7
Descriptor	Mevalonate diphosphate decarboxylase, 1-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}acetyl)-L-proline, GLYCEROL, ... (4 entities in total)
Functional Keywords	ghmp kinase family, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Staphylococcus epidermidis
Total number of polymer chains	2
Total formula weight	74595.31
Authors	Barta, M.L.,McWhorter, W.J.,Geisbrecht, B.V. (deposition date: 2012-02-21, release date: 2012-07-11, Last modification date: 2023-09-13)
Primary citation	Barta, M.L.,McWhorter, W.J.,Miziorko, H.M.,Geisbrecht, B.V. Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase. Biochemistry, 51:5611-5621, 2012 Cited by PubMed: 22734632 DOI: 10.1021/bi300591x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation