3QT6
Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor DPGP
Summary for 3QT6
Entry DOI | 10.2210/pdb3qt6/pdb |
Related | 3QT5 3QT7 3QT8 |
Descriptor | Mevalonate diphosphate decarboxylase, 1-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}acetyl)-L-proline (3 entities in total) |
Functional Keywords | ghmp kinase family, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Staphylococcus epidermidis |
Total number of polymer chains | 2 |
Total formula weight | 74407.04 |
Authors | Barta, M.L.,Skaff, A.D.,McWhorter, W.J.,Miziorko, H.M.,Geisbrecht, B.V. (deposition date: 2011-02-22, release date: 2011-05-11, Last modification date: 2023-09-13) |
Primary citation | Barta, M.L.,Skaff, D.A.,McWhorter, W.J.,Herdendorf, T.J.,Miziorko, H.M.,Geisbrecht, B.V. Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis. J.Biol.Chem., 286:23900-23910, 2011 Cited by PubMed: 21561869DOI: 10.1074/jbc.M111.242016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.047 Å) |
Structure validation
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