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9C5Q	Human DNA polymerase theta helicase domain in microhomology annealed state 2, dimer form Descriptor: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*CP*CP*CP*GP*GP*G)-3'), DNA polymerase theta Authors: Ito, F, Li, Z, Chen, X.S. Deposit date: 2024-06-06 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining. Biorxiv, 2024
9FMD	Integrative model of the human post-catalytic spliceosome (P-complex) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Rothe, P, Plaschka, C, Vorlaender, M.K. Deposit date: 2024-06-05 Release date: 2024-07-10 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Mechanism for the initiation of spliceosome disassembly. Nature, 2024
9BH7	Human DNA polymerase theta helicase domain dimer in the apo form Descriptor: DNA polymerase theta Authors: Zerio, C.J, Lander, G.C. Deposit date: 2024-04-19 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Human polymerase theta helicase positions DNA microhomologies for double-strand break repair To Be Published
9BH6	Human DNA polymerase theta helicase domain tetramer in the apo form Descriptor: DNA polymerase theta Authors: Zerio, C.J, Lander, G.C. Deposit date: 2024-04-19 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Human polymerase theta helicase positions DNA microhomologies for double-strand break repair To Be Published
9BH8	Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology searching conformation Descriptor: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang Authors: Zerio, C.J, Lander, G.C. Deposit date: 2024-04-19 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Human polymerase theta helicase positions DNA microhomologies for double-strand break repair To Be Published
9BHA	Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology annealed conformation Descriptor: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang Authors: Zerio, C.J, Lander, G.C. Deposit date: 2024-04-19 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Human polymerase theta helicase positions DNA microhomologies for double-strand break repair To Be Published
9BH9	Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology aligning conformation Descriptor: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang Authors: Zerio, C.J, Lander, G.C. Deposit date: 2024-04-19 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Human polymerase theta helicase positions DNA microhomologies for double-strand break repair To Be Published
8YLE	Crystal structure of Werner syndrome helicase complexed with AMP-PCP Descriptor: 1,2-ETHANEDIOL, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... Authors: Yang, Y, Fu, L, Sun, X, Cheng, H, Chen, R. Deposit date: 2024-03-06 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structure of werner syndrome helicase complexed with AMP-PCP at 1.86 Angstroms resolution. To Be Published
9ASK	Human DNA polymerase theta helicase domain dimer, apo-form Descriptor: DNA polymerase theta Authors: Ito, F, Li, Z, Chen, X.S. Deposit date: 2024-02-26 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining. Biorxiv, 2024
9ASJ	Human DNA polymerase theta helicase domain in complex with AMP-PNP, dimer form Descriptor: DNA polymerase theta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Ito, F, Li, Z, Chen, X.S. Deposit date: 2024-02-26 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining. Biorxiv, 2024
9ASL	Human DNA polymerase theta helicase domain tetramer, apo-form Descriptor: DNA polymerase theta Authors: Ito, F, Li, Z, Chen, X.S. Deposit date: 2024-02-26 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining. Biorxiv, 2024
8W0A	Human DNA polymerase theta helicase domain in complex with ssDNA, dimer form Descriptor: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*T)-3'), DNA polymerase theta Authors: Ito, F, Li, Z, Chen, X.S. Deposit date: 2024-02-13 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining. Biorxiv, 2024
8VXY	Structure of HamA(E138A,K140A)B-plasmid DNA complex from the Escherichia coli Hachiman defense system Descriptor: ADENOSINE-5'-TRIPHOSPHATE, HamA, HamB, ... Authors: Tuck, O.T, Hu, J.J, Doudna, J.A. Deposit date: 2024-02-06 Release date: 2024-03-13 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Hachiman is a genome integrity sensor. Biorxiv, 2024
8VXC	Structure of HamB-DNA complex, conformation 2, from the Escherichia coli Hachiman defense system Descriptor: DNA (40-MER), HamB Authors: Tuck, O.T, Doudna, J.A. Deposit date: 2024-02-04 Release date: 2024-03-13 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Hachiman is a genome integrity sensor. Biorxiv, 2024
8VX9	Structure of HamAB apo complex from the Escherichia coli Hachiman defense system Descriptor: HamA, HamB Authors: Tuck, O.T, Doudna, J.A. Deposit date: 2024-02-03 Release date: 2024-03-13 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.65 Å) Cite: Hachiman is a genome integrity sensor. Biorxiv, 2024
8VXA	Structure of HamB-DNA complex, conformation 1, from the Escherichia coli Hachiman defense system Descriptor: DNA (40-MER), HamB Authors: Tuck, O.T, Doudna, J.A. Deposit date: 2024-02-03 Release date: 2024-03-13 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.79 Å) Cite: Hachiman is a genome integrity sensor. Biorxiv, 2024
8Y6O	Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Centrosomal AT-AC splicing factor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R. Deposit date: 2024-02-02 Release date: 2024-03-20 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome. Science, 383, 2024
8XXN	Cryo-EM structure of the human 43S ribosome with PDCD4 Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. Deposit date: 2024-01-18 Release date: 2024-05-01 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
8RO1	Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'') Descriptor: CWF19-like protein 1 homolog, CWF19-like protein 2 homolog, Cell division cycle 5-like protein, ... Authors: Vorlaender, M.K, Rothe, P, Plaschka, C. Deposit date: 2024-01-11 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (3 Å) Cite: Mechanism for the initiation of spliceosome disassembly. Nature, 2024
8RO0	Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS') Descriptor: Cell division cycle 5-like protein, Coiled-coil domain-containing protein 12, GCF C-terminal domain-containing protein, ... Authors: Vorlaender, M.K, Rothe, P, Plaschka, C. Deposit date: 2024-01-11 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Mechanism for the initiation of spliceosome disassembly. Nature, 2024
8RM5	Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'SS oligo, NHP2-like protein 1, ... Authors: Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. Deposit date: 2024-01-05 Release date: 2024-05-22 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (6.9 Å) Cite: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
8RC0	Structure of the human 20S U5 snRNP Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Schneider, S, Galej, W.P. Deposit date: 2023-12-05 Release date: 2024-03-27 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure of the human 20S U5 snRNP. Nat.Struct.Mol.Biol., 31, 2024
8V84	60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) Descriptor: 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... Authors: Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. Deposit date: 2023-12-04 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024
8V83	60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) Descriptor: 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... Authors: Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. Deposit date: 2023-12-04 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (2.53 Å) Cite: The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024
8V85	60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Low-pass filtered locally refined map) Descriptor: ATP-dependent RNA helicase DBP10 Authors: Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. Deposit date: 2023-12-04 Release date: 2024-05-01 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024

 

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