PDB: 451 resultsInfo pagesStatus searchChemie searchBIRD

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1D7J	FKBP COMPLEXED WITH 4-HYDROXY-2-BUTANONE Descriptor: 4-HYDROXY-2-BUTANONE, AMMONIUM ION, PROTEIN (FK506-BINDING PROTEIN), ... Authors: Burkhard, P, Taylor, P, Walkinshaw, M.D. Deposit date: 1999-10-18 Release date: 1999-10-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.85 Å) Cite: X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J.Mol.Biol., 295, 2000
6O49	CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339 Descriptor: (2~{S})-~{N}-[3-oxidanylidene-3-[(3,4,5-trimethoxyphenyl)amino]propyl]-1-(phenylmethyl)sulfonyl-piperidine-2-carboxamide, 1,2-ETHANEDIOL, CALCIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2019-02-28 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.85 Å) Cite: CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339 to be published
1U79	Crystal structure of AtFKBP13 Descriptor: FKBP-type peptidyl-prolyl cis-trans isomerase 3 Authors: Gopalan, G, Swaminathan, K. Deposit date: 2004-08-03 Release date: 2004-09-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen Proc.Natl.Acad.Sci.Usa, 101, 2004
6VSI	Crystal structure of FKBP12 of Candida auris Descriptor: Peptidylprolyl isomerase, SULFATE ION Authors: Li, Z, Li, H, Hernandez, G, LeMaster, D. Deposit date: 2020-02-11 Release date: 2020-04-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Crystal structure and transient dimerization for the FKBP12 protein from the pathogenic fungus Candida auris. Biochem.Biophys.Res.Commun., 525, 2020
5OMP	Human FKBP5 protein Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP5, SULFATE ION Authors: Kumar, R, Moche, M, Winblad, B, Pavlov, P. Deposit date: 2017-08-01 Release date: 2017-11-08 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep, 7, 2017
1Y0O	crystal structure of reduced AtFKBP13 Descriptor: FKBP-type peptidyl-prolyl cis-trans isomerase 3 Authors: Gayathri, G, Swaminathan, K. Deposit date: 2004-11-15 Release date: 2005-11-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Crystal structure of reduced AtFKBP13 to be published
1Q1C	Crystal structure of N(1-260) of human FKBP52 Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, FK506-binding protein 4 Authors: Wu, B, Li, P, Lou, Z, Ding, Y, Shu, C, Shen, B, Rao, Z. Deposit date: 2003-07-18 Release date: 2004-06-22 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex Proc.Natl.Acad.Sci.USA, 101, 2004
3UQB	Crystal structure of a SMT Fusion PEPTIDYL-PROLYL CIS-TRANS ISOMERASE with surface mutation D44G from Burkholderia pseudomallei complexed with FK506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-11-19 Release date: 2011-11-30 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
1BL4	FKBP MUTANT F36V COMPLEXED WITH REMODELED SYNTHETIC LIGAND Descriptor: PROTEIN (FK506 BINDING PROTEIN), {3-[3-(3,4-DIMETHOXY-PHENYL)-1-(1-{1-[2-(3,4,5-TRIMETHOXY-PHENYL)-BUTYRYL]-PIPERIDIN-2YL}-VINYLOXY)-PROPYL]-PHENOXY}-ACETIC ACID Authors: Hatada, M.H, Clackson, T, Yang, W, Rozamus, L.W, Amara, J, Rollins, C.T, Stevenson, L.F, Magari, S.R, Wood, S.A, Courage, N.L, Lu, X, Cerasoli Junior, F, Gilman, M, Holt, D. Deposit date: 1998-07-23 Release date: 1998-09-02 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.USA, 95, 1998
4JYS	Crystal structure of FKBP25 from Plasmodium Vivax Descriptor: CHLORIDE ION, IMIDAZOLE, Peptidyl-prolyl cis-trans isomerase Authors: Sreekanth, R, Yoon, H.S. Deposit date: 2013-04-01 Release date: 2014-02-12 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of Plasmodium vivax FK506-binding protein 25 reveals conformational changes responsible for its noncanonical activity Proteins, 82, 2014
7U0U	Crystal Structure of a Aspergillus fumigatus Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, PHOSPHATE ION, ... Authors: Fox III, D, Abendroth, J, DeBouver, N.D, Hoy, M.J, Heitman, J, Lorimer, D.D, Horanyi, P.S, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-02-18 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. Mbio, 13, 2022
1D7H	FKBP COMPLEXED WITH DMSO Descriptor: AMMONIUM ION, DIMETHYL SULFOXIDE, PROTEIN (FK506-BINDING PROTEIN), ... Authors: Burkhard, P, Taylor, P, Walkinshaw, M.D. Deposit date: 1999-10-18 Release date: 1999-10-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J.Mol.Biol., 295, 2000
1D7I	FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS) Descriptor: AMMONIUM ION, METHYL METHYLSULFINYLMETHYL SULFIDE, PROTEIN (FK506-BINDING PROTEIN), ... Authors: Burkhard, P, Taylor, P, Walkinshaw, M.D. Deposit date: 1999-10-18 Release date: 1999-10-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J.Mol.Biol., 295, 2000
5I7Q	Crystal structure of Fkbp12-IF(SlpA), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlpA Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A,FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase,Peptidyl-prolyl cis-trans isomerase FKBP1A Authors: Jakob, R.P, Dobbek, H, Schmid, F.X. Deposit date: 2016-02-18 Release date: 2017-03-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and Functional Analysis of Chaperone Domain Insertion in Fkbp12 To Be Published
4MSP	Crystal structure of human peptidyl-prolyl cis-trans isomerase FKBP22 (aka FKBP14) containing two EF-hand motifs Descriptor: CALCIUM ION, PENTAETHYLENE GLYCOL, Peptidyl-prolyl cis-trans isomerase FKBP14, ... Authors: Boudko, S.P, Ishikawa, Y, Bachinger, H.P. Deposit date: 2013-09-18 Release date: 2013-12-25 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of human peptidyl-prolyl cis-trans isomerase FKBP22 containing two EF-hand motifs. Protein Sci., 23, 2014
4IQC	P3121 crystal form of FKBP12.6 Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B Authors: Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G. Deposit date: 2013-01-11 Release date: 2014-01-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.903 Å) Cite: Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6. Acta Crystallogr.,Sect.D, 70, 2014
4ODR	Structure of SlyD delta-IF from Thermus thermophilus in complex with FK506 Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, ACETATE ION, CHLORIDE ION, ... Authors: Quistgaard, E.M, Low, C, Nordlund, P. Deposit date: 2014-01-10 Release date: 2015-01-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.929 Å) Cite: Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol., 14, 2016
6VCT	Mucor circinelloides FKBP12 protein bound with APX879 in C2221 space group Descriptor: N'-[(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide, Peptidylprolyl isomerase Authors: Gobeil, S, Spicer, L. Deposit date: 2019-12-23 Release date: 2020-12-16 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio, 12, 2021
1FKH	DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 Descriptor: 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE, FK506 BINDING PROTEIN Authors: Holt, D.A, Luengo, J.I, Yamashita, D.S, Oh, H.-J, Konialian, A.L, Yen, H.-K, Rozamus, L.W, Brandt, M, Bossard, M.J, Levy, M.A, Eggleston, D.S, Stout, T.J, Liang, J, Schultz, L.W, Clardy, J. Deposit date: 1993-08-05 Release date: 1994-01-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.95 Å) Cite: DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12. J.Am.Chem.Soc., 115, 1993
3PR9	Structural analysis of protein folding by the Methanococcus jannaschii chaperone FKBP26 Descriptor: FKBP-type peptidyl-prolyl cis-trans isomerase Authors: Martinez-Hackert, E, Hendrickson, W.A. Deposit date: 2010-11-29 Release date: 2011-01-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural Analysis of Protein Folding by the Long-Chain Archaeal Chaperone FKBP26. J.Mol.Biol., 407, 2011
3KZ7	C-terminal domain of Murine FKBP25 rapamycin complex Descriptor: FK506-binding protein 3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG Authors: Stura, E.A, Galat, A. Deposit date: 2009-12-08 Release date: 2010-12-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Diversified targets of FKBP25 and its complex with rapamycin. Int.J.Biol.Macromol., 69, 2014
4FN2	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 Descriptor: Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase, ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-06-19 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4GGQ	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 Descriptor: 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-08-07 Release date: 2012-08-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
1Q6H	Crystal structure of a truncated form of FkpA from Escherichia coli Descriptor: FKBP-type peptidyl-prolyl cis-trans isomerase fkpA Authors: Saul, F.A, Arie, J.-P, Vulliez-le Normand, B, Kahn, R, Betton, J.-M, Bentley, G.A. Deposit date: 2003-08-13 Release date: 2004-01-13 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural and functional studies of FkpA from Escherichia coli, a cis/trans peptidyl-prolyl isomerase with chaperone activity. J.Mol.Biol., 335, 2004
4NNR	FKBP13-FK506 Complex Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Peptidyl-prolyl cis-trans isomerase FKBP2 Authors: Schultz, L.W, Martin, P.K, Liang, J, Schreiber, S.L, Clardy, J. Deposit date: 2013-11-18 Release date: 2014-02-05 Last modified: 2019-11-13 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Atomic structure of the Immunophilin FKBP13-FK506 Complex: Insights into the Composite Binding Surface for Calcineurin J.Am.Chem.Soc., 116, 1994

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