PDB: 608 resultsInfo pagesStatus searchChemie searchBIRD

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4FL5	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Schumacher, B, Ottmann, C. Deposit date: 2012-06-14 Release date: 2013-12-11 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J., 29, 2015
3SMO	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin J aglycone Descriptor: 14-3-3 protein sigma, Fusicoccin J aglycone, MAGNESIUM ION, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-06-28 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3SML	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin A aglycone Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin A aglycone, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-06-28 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3SMK	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenin A Descriptor: 14-3-3 protein sigma, Cotylenin A, MAGNESIUM ION, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-06-28 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3SMN	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin A-THF Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-06-28 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3SMM	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin J aglycone, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-06-28 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
3T0L	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Ottmann, C. Deposit date: 2011-07-20 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
3T0M	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: (2-{2-[(2,5-dimethoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Thiel, P, Ottmann, C. Deposit date: 2011-07-20 Release date: 2012-12-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
3SP5	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenol Descriptor: 14-3-3 protein sigma, Cotylenol, MAGNESIUM ION, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-07-01 Release date: 2016-05-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem.Biol., 20, 2013
3SPR	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer FC-THF Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin A-THF, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-07-03 Release date: 2012-07-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.99 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
4GNT	Complex of ChREBP and 14-3-3beta Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION Authors: Zhang, H, Huang, N. Deposit date: 2012-08-17 Release date: 2012-10-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b To be Published
3UAL	Crystal Structure of 14-3-3 epsilon with Mlf1 peptide Descriptor: 14-3-3 protein epsilon, Myeloid leukemia factor 1, TERTIARY-BUTYL ALCOHOL Authors: Weyand, M, Ottmann, C. Deposit date: 2011-10-21 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights of the MLF1/14-3-3 interaction. Febs J., 279, 2012
3U9X	Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2011-10-20 Release date: 2012-05-09 Last modified: 2012-05-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 109, 2012
6G8P	14-3-3sigma in complex with a P129beta3P and L132beta3L mutated YAP pS127 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. Deposit date: 2018-04-09 Release date: 2019-04-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
6G8L	14-3-3sigma in complex with a L132beta3L mutated YAP pS127 phosphopeptide Descriptor: 14-3-3 protein sigma, ACE-ARG-ALA-HIS-SEP-SER-PRO-ALA-SER-BLE-GLN, CHLORIDE ION, ... Authors: Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. Deposit date: 2018-04-09 Release date: 2019-04-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.37 Å) Cite: A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
6G8J	14-3-3sigma in complex with a A130beta3A mutated YAP pS127 phosphopeptide Descriptor: 14-3-3 protein sigma, ACE-ARG-ALA-HIS-SEP-SER-PRO-BAL-SER-LEU-GLN, CHLORIDE ION, ... Authors: Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. Deposit date: 2018-04-09 Release date: 2019-04-17 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.47 Å) Cite: A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
6G6X	14-3-3sigma in complex with a P129beta3P mutated YAP pS127 phosphopeptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, SODIUM ION, ... Authors: Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. Deposit date: 2018-04-03 Release date: 2019-04-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.13 Å) Cite: A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
6G8I	14-3-3sigma in complex with a R124beta3R mutated YAP pS127 phosphopeptide Descriptor: 14-3-3 protein sigma, ALA-HIS-SEP-SER-PRO-ALA-SER-LEU-GLN, CHLORIDE ION, ... Authors: Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. Deposit date: 2018-04-09 Release date: 2019-04-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
6G8Q	14-3-3sigma in complex with a A130beta3A and Q133beta3Q mutated YAP pS127 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. Deposit date: 2018-04-09 Release date: 2019-04-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
6GKF	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser139 Descriptor: 14-3-3 protein gamma, Caspase-2 Authors: Alblova, M, Obsil, T, Obsilova, V. Deposit date: 2018-05-20 Release date: 2018-10-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.598 Å) Cite: 14-3-3 protein masks the nuclear localization sequence of caspase-2. FEBS J., 285, 2018
6GHP	14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Potassium channel subfamily K member 9, ... Authors: Andrei, S.A, de Vink, P.J, Brunsveld, L, Ottmann, C, Higuchi, Y. Deposit date: 2018-05-08 Release date: 2018-08-01 Last modified: 2018-10-17 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed. Engl., 57, 2018
6GKG	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser164 Descriptor: 14-3-3 protein gamma, Caspase-2 Authors: Alblova, M, Obsil, T, Obsilova, V. Deposit date: 2018-05-20 Release date: 2018-10-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.847 Å) Cite: 14-3-3 protein masks the nuclear localization sequence of caspase-2. FEBS J., 285, 2018
6HEP	Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768 Descriptor: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Ottmann, C, Brunsveld, L. Deposit date: 2018-08-20 Release date: 2018-10-24 Last modified: 2018-11-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions. J. Am. Chem. Soc., 140, 2018
6HN2	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5 Descriptor: 14-3-3 protein sigma, 2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide, Estrogen Receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-13 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
6HMT	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 2 Descriptor: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen Receptor, ... Authors: Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. Deposit date: 2018-09-12 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019

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