3SP5

Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenol

Summary for 3SP5

Related2O98 3LW1 3IQU
Descriptor14-3-3 protein sigma, TASK-3 peptide, Cotylenol, ... (5 entities in total)
Functional Keywordshelical protein, phosphoprotein, adapter protein, peptide binding protein
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm P31947
Total number of polymer chains2
Total molecular weight27761.95
Authors
Anders, C.,Schumacher, B.,Ottmann, C. (deposition date: 2011-07-01, release date: 2016-05-04, Last modification date: 2017-11-08)
Primary citation
Anders, C.,Higuchi, Y.,Koschinsky, K.,Bartel, M.,Schumacher, B.,Thiel, P.,Nitta, H.,Preisig-Muller, R.,Schlichthorl, G.,Renigunta, V.,Ohkanda, J.,Daut, J.,Kato, N.,Ottmann, C.
A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.
Chem.Biol., 20:583-593, 2013
PubMed: 23601647 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2013.03.015
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2111601.5%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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167518
PDB entries from 2020-08-12