Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenol

Summary for 3SP5

Related2O98 3LW1 3IQU
Descriptor14-3-3 protein sigma, TASK-3 peptide, Cotylenol, ... (5 entities in total)
Functional Keywordshelical protein, phosphoprotein, adapter protein, peptide binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P31947
Total number of polymer chains2
Total molecular weight27761.95
Anders, C.,Schumacher, B.,Ottmann, C. (deposition date: 2011-07-01, release date: 2016-05-04, Last modification date: 2017-11-08)
Primary citation
Anders, C.,Higuchi, Y.,Koschinsky, K.,Bartel, M.,Schumacher, B.,Thiel, P.,Nitta, H.,Preisig-Muller, R.,Schlichthorl, G.,Renigunta, V.,Ohkanda, J.,Daut, J.,Kato, N.,Ottmann, C.
A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.
Chem.Biol., 20:583-593, 2013
PubMed: 23601647 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2013.03.015
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2111601.5%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-12