PDB: 253 件ウェブページステータス検索Chemie searchBIRD

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6A1Z	Crystal Structure of dimeric Kinesin-3 KIF13B 分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin family member 13B, MAGNESIUM ION 著者 Ren, J.Q, Wang, S, Feng, W. 登録日 2018-06-08 公開日 2018-11-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3WPN	Kinesin spindle protein Eg5 in complex with ATP-competitive inhibitor PVZB1194 分子名称: 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-sulfonamide, Kinesin-like protein KIF11 著者 Yokoyama, H, Katoh, S, Fujii, S. 登録日 2014-01-14 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of new allosteric inhibition in Kinesin spindle protein eg5 Acs Chem.Biol., 10, 2015
6Y1I	Human Eg5 motor domain mutant R234C 分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION 著者 Garcia-Saez, I, Skoufias, D.A. 登録日 2020-02-12 公開日 2021-06-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Human Eg5 motor domain mutant R234C To Be Published
3WRD	Crystal Structure of the KIF5C Motor Domain Without Any Nucleotide 分子名称: Kinesin heavy chain isoform 5C, SULFATE ION 著者 Inoue, S, Nitta, R, Hirokawa, N. 登録日 2014-02-21 公開日 2015-04-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding Embo J., 34, 2015
3ZFD	Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP 分子名称: CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. 登録日 2012-12-11 公開日 2013-03-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Structural Basis for the ATP-Induced Isomerization of Kinesin. J.Mol.Biol., 425, 2013
3X2T	Crystal Structure of the KIF5C Motor Domain With ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin heavy chain isoform 5C 著者 Inoue, S, Nitta, R, Hirokawa, N. 登録日 2015-01-02 公開日 2015-04-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding Embo J., 34, 2015
3ZFC	Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP 分子名称: CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. 登録日 2012-12-11 公開日 2013-03-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for the ATP-Induced Isomerization of Kinesin. J.Mol.Biol., 425, 2013
3ZCW	Eg5 - New allosteric binding site 分子名称: (2E)-2-(3-fluoranyl-4-methoxy-phenyl)imino-1-[[2-(trifluoromethyl)phenyl]methyl]-3H-benzimidazole-5-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Ulaganathan, V, Talapatra, S.K, Kozielski, F, Pannifer, A.D. 登録日 2012-11-23 公開日 2013-01-23 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.691 Å) 主引用文献 Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein. J.Am.Chem.Soc., 135, 2013
4A1Z	Eg5-1 分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2011-09-20 公開日 2012-10-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
4A14	HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING 分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION 著者 Klejnot, M, Kozielski, F. 登録日 2011-09-14 公開日 2012-01-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling. Acta Crystallogr.,Sect.D, 68, 2012
4A28	Eg5-2 分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION 著者 Talapatra, S.K, Kozielski, F. 登録日 2011-09-22 公開日 2012-10-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
4AP0	The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ... 著者 Schuettelkopf, A.W, Talapatra, S.K, Kozielski, F. 登録日 2012-03-30 公開日 2012-09-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.594 Å) 主引用文献 The Structure of the Ternary Eg5-Adp-Ispinesib Complex Acta Crystallogr.,Sect.D, 68, 2012
4A51	Crystal structure of human kinesin Eg5 in complex with 1-(3-(((2-Aminoethyl)thio)diphenylmethyl)phenyl)ethanone hydrochloride 分子名称: 1-(3-{[(2-aminoethyl)sulfanyl](diphenyl)methyl}phenyl)ethanone, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Kaan, H.Y.K, Kozielski, F. 登録日 2011-10-24 公開日 2012-10-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity. J.Med.Chem., 55, 2012
4A5Y	Intermediate state of human kinesin Eg5 in complex with Ispinesib 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ... 著者 Kaan, H.Y.K, Kozielski, F. 登録日 2011-10-29 公開日 2012-11-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 "Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5. J.Biol.Chem., 288, 2013
4A50	Crystal structure of human kinesin Eg5 in complex with 2-Amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid 分子名称: (2R)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, (2S)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Kaan, H.Y.K, Kozielski, F. 登録日 2011-10-24 公開日 2012-10-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity. J.Med.Chem., 55, 2012
4AS7	Eg5 complex 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CHLORIDE ION, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2012-04-29 公開日 2013-05-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
4B7B	Eg5-3 分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CALCIUM ION, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2012-08-17 公開日 2013-07-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism. J.Med.Chem., 56, 2013
4BBG	Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol 分子名称: 3-[(R)-2-azanylethylsulfanyl-(3-ethylphenyl)-phenyl-methyl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Kaan, H.Y.K, Kozielski, F. 登録日 2012-09-22 公開日 2013-05-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models. J.Med.Chem., 56, 2013
7D8V	Crystal Structure of A Kinesin-3 KIF13B mutant-T192Y 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin family member 13B, ... 著者 Ren, J.Q, Feng, W. 登録日 2020-10-10 公開日 2021-10-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A. Plos Genet., 17, 2021
6ZPH	Kinesin binding protein complexed with Kif15 motor domain 分子名称: ADENOSINE-5'-DIPHOSPHATE, KIF-binding protein, Kinesin-like protein KIF15, ... 著者 Atherton, J, Hummel, J.J.A, Olieric, N, Locke, J, Pena, A, Rosenfeld, S.S, Steinmetz, M.O, Hoogenraad, C.C, Moores, C.A. 登録日 2020-07-08 公開日 2020-12-30 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 The mechanism of kinesin inhibition by kinesin-binding protein. Elife, 9, 2020
7WRG	Crystal structure of full-length kinesin-3 KLP-6 分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein, MAGNESIUM ION 著者 Wang, W.J, Ren, J.Q, Song, W.Y, Feng, W. 登録日 2022-01-26 公開日 2022-08-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition. Nat Commun, 13, 2022
4ETP	C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Kinesin-like protein KAR3, ... 著者 Rank, K.C, Chen, C.J, Cope, J, Porche, K, Hoenger, A, Gilbert, S.P, Rayment, I. 登録日 2012-04-24 公開日 2012-06-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern. J.Cell Biol., 197, 2012
4H1G	Structure of Candida albicans Kar3 motor domain fused to maltose-binding protein 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Allingham, J.A, Duan, D, Delorme, C, Joshi, M. 登録日 2012-09-10 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein. Biochem.Biophys.Res.Commun., 428, 2012
7RYP	Cryo-EM structure of KIFBP:KIF15 分子名称: KIF-binding protein, Kinesin-like protein KIF15 著者 Solon, A.L, Tan, Z, Schutt, K.L, Jepsen, L, Haynes, S.E, Nesvizhskii, A.I, Sept, D, Stumpff, J, Ohi, R, Cianfrocco, M.A. 登録日 2021-08-25 公開日 2021-09-08 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Sci Adv, 7, 2021
7RSI	The cryo-EM map of KIF18A bound to KIFBP 分子名称: ADENOSINE-5'-DIPHOSPHATE, KIF-binding protein, Kinesin-like protein KIF18A, ... 著者 Tan, Z, Solon, A.L, Schutt, K.L, Jepsen, L, Haynes, S.E, Nesvizhskii, A.I, Sept, D, Stumpff, J, Ohi, R, Cianfrocco, M.A. 登録日 2021-08-11 公開日 2021-09-08 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Sci Adv, 7, 2021

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