PDB: 1333 件ウェブページステータス検索Chemie searchBIRD

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8EXG	Human Carbonic Anhydrase II bound N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)-4-sulfamoylbenzamide 分子名称: (4S)-5-amino-4-{1,3-dioxo-4-[(2-{2-[2-(4-sulfamoylbenzamido)ethoxy]ethoxy}ethyl)amino]-1,3-dihydro-2H-isoindol-2-yl}-5-oxopentanoic acid, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Kohlbrand, A.J, O'Herin, C.B. 登録日 2022-10-25 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023
8EXC	Human Carbonic Anhydrase II bound tert-butyl (3-(4-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)butoxy)propyl)carbamate 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, N-(3-{4-[3-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}amino)propoxy]butoxy}propyl)-4-sulfamoylbenzamide, ... 著者 Kohlbrand, A.J, O'Herin, C.B. 登録日 2022-10-25 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023
8EYL	Human Carbonic Anhydrase II with Tert-butyl (2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)carbamate 分子名称: 2-[[(2~{R})-1-azanyl-5-oxidanyl-1,5-bis(oxidanylidene)pentan-2-yl]carbamoyl]-6-[2-[2-[(4-sulfamoylphenyl)carbonylamino]ethoxy]ethylamino]benzoic acid, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Kohlbrand, A.J, O'Herin, C.B. 登録日 2022-10-27 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J.Med.Chem., 2023
8FR2	Carbonic Anhydrase IX-mimic in complex with the alkyl urea compound 3h 分子名称: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Combs, J.C, McKenna, R. 登録日 2023-01-06 公開日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.307 Å) 主引用文献 New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors. Molecules, 28, 2023
8FQY	Carbonic Anhydrase II in complex with the alkyl urea 3h 分子名称: 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Combs, J.C, McKenna, R. 登録日 2023-01-06 公開日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.466 Å) 主引用文献 New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors. Molecules, 28, 2023
8FR1	Carbonic Anhydrase IX in complex with the alkyl urea compound 3g 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ... 著者 Combs, J.C, McKenna, R. 登録日 2023-01-06 公開日 2023-02-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors. Molecules, 28, 2023
8FQX	Carbonic Anhydrase II in complex with the alkyl ureas 3g 分子名称: 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Combs, J.E, McKenna, R. 登録日 2023-01-06 公開日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.496 Å) 主引用文献 New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors. Molecules, 28, 2023
8FQZ	Carbonic Anhydrase II in complex with the alkyl urea 3j 分子名称: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Combs, J.C, McKenna, R. 登録日 2023-01-06 公開日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.467 Å) 主引用文献 New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors. Molecules, 28, 2023
8FR4	Carbonic Anhydrase IX-mimic in complex with the alkyl urea compound 3j 分子名称: 4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Combs, J.E, McKenna, R. 登録日 2023-01-06 公開日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.123 Å) 主引用文献 New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors. Molecules, 28, 2023
3TVO	Human Carbonic Anhydrase II Proton Transfer Double Mutant 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Mikulski, R.M. 登録日 2011-09-20 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II. Biochemistry, 52, 2013
3TVN	Human Carbonic Anhydrase II Proton Transfer Mutant 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Mikulski, R.L, West, D.M, Sippel, K.H, Avvaru, B.S, Chingkuang, T, McKenna, R. 登録日 2011-09-20 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.497 Å) 主引用文献 Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II. Biochemistry, 52, 2013
3U3A	structure of Human Carbonic Anhydrase II V143I 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 West, D, Mckenna, R. 登録日 2011-10-05 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.549 Å) 主引用文献 Structural Analysis of Human Carbonic Anhydrase II Binding Pocket To be Published
3U7C	crystal structure of the V143I mutant of human carbonic anhydrase II 分子名称: BICARBONATE ION, CARBON DIOXIDE, Carbonic anhydrase 2, ... 著者 West, D.M, Kim, C.U, Robbins, A.H, Mckenna, R. 登録日 2011-10-13 公開日 2013-02-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.93 Å) 主引用文献 crystal structure of the V143I mutant of human carbonic anhydrase II To be Published
3V2M	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Aggarwal, M, McKenna, A. 登録日 2011-12-12 公開日 2012-12-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.471 Å) 主引用文献 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II To be Published
3UYN	HCA 3 分子名称: Carbonic anhydrase 3, ZINC ION 著者 Fisher, Z, McKenna, R. 登録日 2011-12-06 公開日 2012-02-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III. Proteins, 68, 2007
3V3J	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V3G	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5581 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3UYQ	HCA 3 分子名称: Carbonic anhydrase 3, ZINC ION 著者 Fisher, Z, McKenna, R. 登録日 2011-12-06 公開日 2011-12-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III. Proteins, 68, 2007
3V2J	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION 著者 Aggarwal, M, McKenna, A. 登録日 2011-12-12 公開日 2012-12-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II To be Published
3V3F	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V3I	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V5G	Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, 4-(sulfamoylamino)benzenesulfonamide, Carbonic anhydrase 2, ... 著者 D'Ambrosio, K, De Simone, G. 登録日 2011-12-16 公開日 2012-07-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups. J.Med.Chem., 55, 2012
3V3H	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: CHLORIDE ION, Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3V7X	Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide 分子名称: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ... 著者 Mader, P, Brynda, J, Rezacova, P. 登録日 2011-12-22 公開日 2012-04-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. J.Med.Chem., 55, 2012
3VBD	Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide 分子名称: 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Mader, P, Brynda, J, Rezacova, P. 登録日 2012-01-02 公開日 2012-04-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Synthesis, Structure-Activity Relationship Studies, and X-ray Crystallographic Analysis of Arylsulfonamides as Potent Carbonic Anhydrase Inhibitors. J.Med.Chem., 55, 2012

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