3LJU
| Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3 | Descriptor: | (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION | Authors: | Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-01-26 | Release date: | 2010-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3VIA
| |
4HHV
| Crystal structure of ceramide transfer protein pleckstrin homology domain | Descriptor: | ACETATE ION, CHLORIDE ION, Collagen type IV alpha-3-binding protein, ... | Authors: | Prashek, J, Truong, T, Yao, X. | Deposit date: | 2012-10-10 | Release date: | 2013-11-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structure of the Pleckstrin Homology Domain from the Ceramide Transfer Protein: Implications for Conformational Change upon Ligand Binding. Plos One, 8, 2013
|
|
2I5C
| Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,4,5)P5 | Descriptor: | (1R,2S,3R,4S,5S,6R)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL PENTAKIS[DIHYDROGEN (PHOSPHATE)], Pleckstrin | Authors: | Jackson, S.G, Haslam, R.J, Junop, M.S. | Deposit date: | 2006-08-24 | Release date: | 2007-08-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate. Bmc Struct.Biol., 7, 2007
|
|
4A5K
| |
2Z0Q
| Crystal structure of DH-PH domain of RhoGEF3(Xpln) | Descriptor: | Rho guanine nucleotide exchange factor 3, SULFATE ION | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-07 | Release date: | 2008-05-13 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Acta Crystallogr.,Sect.F, 68, 2012
|
|
1FAO
| STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE | Descriptor: | DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | Authors: | Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A. | Deposit date: | 2000-07-13 | Release date: | 2000-07-20 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol.Cell, 6, 2000
|
|
5C6R
| Crystal structure of PH domain of ASAP1 | Descriptor: | Arf-GAP, PHOSPHATE ION, TRIETHYLENE GLYCOL | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2015-06-23 | Release date: | 2015-10-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1. Structure, 23, 2015
|
|
4A6K
| Crystal structure of Slm1-PH domain in complex with D-myo-Inositol-4- phosphate | Descriptor: | D-MYO-INOSITOL-4-PHOSPHATE, PHOSPHATE ION, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1 | Authors: | Anand, K, Maeda, K, Gavin, A.C. | Deposit date: | 2011-11-04 | Release date: | 2012-06-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site Plos One, 7, 2012
|
|
1U2B
| Triglycine variant of the Grp1 Pleckstrin Homology Domain unliganded | Descriptor: | Cytohesin 3, SULFATE ION | Authors: | Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G. | Deposit date: | 2004-07-16 | Release date: | 2005-02-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains Embo J., 23, 2004
|
|
1U29
| Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,4,5)P3 | Descriptor: | Cytohesin 2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE | Authors: | Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G. | Deposit date: | 2004-07-16 | Release date: | 2005-02-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains Embo J., 23, 2004
|
|
2P0D
| ArhGAP9 PH domain in complex with Ins(1,4,5)P3 | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Rho GTPase-activating protein 9 | Authors: | Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F. | Deposit date: | 2007-02-28 | Release date: | 2007-03-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.811 Å) | Cite: | Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9. J.Biol.Chem., 282, 2007
|
|
4KAX
| Crystal structure of the Grp1 PH domain in complex with Arf6-GTP | Descriptor: | ADP-ribosylation factor 6, CITRIC ACID, Cytohesin-3, ... | Authors: | Lambright, D.G, Malaby, A.W, van den Berg, B. | Deposit date: | 2013-04-23 | Release date: | 2013-08-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
2VRW
| |
6OLU
| RIAM RA-PH core structure in the P212121 space group | Descriptor: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | Authors: | Wu, J. | Deposit date: | 2019-04-17 | Release date: | 2020-04-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. Structure, 29, 2021
|
|
7NH5
| |
2Y7B
| Crystal structure of the PH domain of human Actin-binding protein anillin ANLN | Descriptor: | 1,2-ETHANEDIOL, ACTIN-BINDING PROTEIN ANILLIN | Authors: | Vollmar, M, Wang, J, Krojer, T, Elkins, J, Filippakopoulos, P, Ugochukwu, E, Cocking, R, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S. | Deposit date: | 2011-01-31 | Release date: | 2011-03-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of the Ph Domain of Human Actin-Binding Protein Anillin Anln To be Published
|
|
2R09
| Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... | Authors: | DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G. | Deposit date: | 2007-08-17 | Release date: | 2007-12-04 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors. Mol.Cell, 28, 2007
|
|
1FHW
| Structure of the pleckstrin homology domain from GRP1 in complex with inositol(1,3,4,5,6)pentakisphosphate | Descriptor: | GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5,6)-PENTAKISPHOSPHATE, SULFATE ION | Authors: | Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A. | Deposit date: | 2000-08-02 | Release date: | 2000-08-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains Mol.Cell, 6, 2000
|
|
3FEH
| Crystal structure of full length centaurin alpha-1 | Descriptor: | Centaurin-alpha-1, UNKNOWN ATOM OR ION, ZINC ION | Authors: | Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-11-29 | Release date: | 2008-12-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3RCP
| Crystal structure of the FAPP1 pleckstrin homology domain | Descriptor: | GLYCEROL, Pleckstrin homology domain-containing family A member 3 | Authors: | Roy, S, He, J, Kutateladze, T.G. | Deposit date: | 2011-03-31 | Release date: | 2011-04-20 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain. J.Biol.Chem., 286, 2011
|
|
4F7H
| The crystal structure of kindlin-2 pleckstrin homology domain in free form | Descriptor: | Fermitin family homolog 2, S,R MESO-TARTARIC ACID | Authors: | Liu, Y, Zhu, Y, Qin, J, Ye, S, Zhang, R. | Deposit date: | 2012-05-16 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation. Protein Cell, 3, 2012
|
|
1U5F
| |
6BNM
| Crystal Structure of the P-Rex2 PH domain | Descriptor: | CHLORIDE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein | Authors: | Cash, J.N, Sharma, P.V, Tesmer, J.J.G. | Deposit date: | 2017-11-17 | Release date: | 2018-11-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3. J.Struct.Biol., 1, 2019
|
|
2P0H
| ArhGAP9 PH domain in complex with Ins(1,3,4)P3 | Descriptor: | (1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL, Rho GTPase-activating protein 9 | Authors: | Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F. | Deposit date: | 2007-02-28 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9. J.Biol.Chem., 282, 2007
|
|