PDB: 367 件ウェブページステータス検索Chemie searchBIRD

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8I6Z	Crystal structure of apo-form of malonyl-CoA reductase C-domain from Chloroflexus aurantiacus 分子名称: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR 著者 Kim, S, Kim, K.-J. 登録日 2023-01-30 公開日 2023-06-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
1YB1	Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI 分子名称: 17-beta-hydroxysteroid dehydrogenase type XI, Androsterone, CHLORIDE ION, ... 著者 Lukacik, P, Bunkoczi, G, Kavanagh, K, Ng, S, von Delft, F, Bray, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2004-12-18 公開日 2004-12-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI. To be Published
1SEP	MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND SEPIAPTERIN 分子名称: BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SEPIAPTERIN REDUCTASE 著者 Auerbach, G, Herrmann, A, Guetlich, M, Fischer, M, Jacob, U, Bacher, A, Huber, R. 登録日 1997-05-23 公開日 1999-01-13 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. EMBO J., 16, 1997
4IMR	Crystal structure of 3-oxoacyl (acyl-carrier-protein) reductase (target EFI-506442) from agrobacterium tumefaciens C58 with NADP bound 分子名称: 3-oxoacyl-(Acyl-carrier-protein) reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, UNKNOWN LIGAND 著者 Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Al Obaidi, N.F, Stead, M, Love, J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2013-01-03 公開日 2013-01-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Crystal Structure of 3-Oxoacyl (Acyl-Carrier-Protein) Reductase Atu5465 from Agrobacterium Tumefaciens To be Published
4K1L	4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes 分子名称: (4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Loenze, P, Schimanski-Breves, S, Von der Heyden, C, Engel, C.K. 登録日 2013-04-05 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11-HSD1 inhibitors for the treatment of diabetes. Bioorg.Med.Chem.Lett., 23, 2013
3WXB	Crystal structure of NADPH bound carbonyl reductase from chicken fatty liver 分子名称: 1,2-ETHANEDIOL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Uncharacterized protein 著者 Yoneda, K, Sakuraba, H, Fukuda, Y, Sone, T, Araki, T, Ohshima, T. 登録日 2014-07-29 公開日 2015-07-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 A novel NAD(P)H-dependent carbonyl reductase specifically expressed in the thyroidectomized chicken fatty liver: catalytic properties and crystal structure. Febs J., 282, 2015
3RJ9	Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+ 分子名称: Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Morgunova, E, Wuxiuer, Y, Cols, N, Popov, A, Sylte, I, Karshikoff, A, Gonzales-Duarte, R, Ladenstein, R, Winberg, J.O. 登録日 2011-04-15 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. Febs J., 279, 2012
6ZE0	Orthorhombic crystal structure of the bulky-bulky ketone specific alcohol dehydrogenase from Comamonas testosteroni 分子名称: alcohol dehydrogenase 著者 Toelzer, C, Niefind, K. 登録日 2020-06-15 公開日 2020-11-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile Catalysts, 2020
6K8U	Crystal structure of C-domain with NADP of baterial malonyl-CoA reductase 分子名称: GLYCEROL, NAD-dependent epimerase/dehydratase:Short-chain dehydrogenase/reductase SDR, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Kim, S, Kim, K.-J. 登録日 2019-06-13 公開日 2020-03-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insight into bi-functional malonyl-CoA reductase. Environ.Microbiol., 22, 2020
1E3W	Rat brain 3-hydroxyacyl-CoA dehydrogenase binary complex with NADH and 3-keto butyrate 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETOACETIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Powell, A.J, Read, J.A, Brady, R.L. 登録日 2000-06-26 公開日 2001-05-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Recognition of Structurally Diverse Substrates by Type II 3-Hydroxyacyl-Coa Dehydrogenase (Hadh II) Amyloid-Beta Binding Alcohol Dehydrogenase (Abad) J.Mol.Biol., 303, 2000
1E3S	Rat brain 3-hydroxyacyl-CoA dehydrogenase binary complex with NADH 分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE 著者 Powell, A.J, Read, J.A, Banfield, M.J, Brady, R.L. 登録日 2000-06-22 公開日 2001-05-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Recognition of Structurally Diverse Substrates by Type II 3-Hydroxyacyl-Coa Dehydrogenase (Hadh II) Amyloid-Beta Binding Alcohol Dehydrogenase (Abad) J.Mol.Biol., 303, 2000
8AET	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal E779W variant 分子名称: SULFATE ION, Short-chain dehydrogenase/reductase SDR 著者 Kabasakal, B.V, Murray, J.W. 登録日 2022-07-13 公開日 2023-04-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8HI6	Crystal structure of the NADP+ and MSA bound N terminal domain of bi-functional malonyl-CoA reductase from Roseiflexus castenholzii 分子名称: 3-oxidanylidenepropanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR 著者 Zhang, X, Wu, W.P, Xu, X. 登録日 2022-11-18 公開日 2023-05-31 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii. Mbio, 14, 2023
1BDB	CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE FROM PSEUDOMONAS SP. LB400 分子名称: CIS-BIPHENYL-2,3-DIHYDRODIOL-2,3-DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Huelsmeyer, M, Hecht, H.-J, Niefind, K, Hofer, B, Timmis, K.N, Schomburg, D. 登録日 1997-05-10 公開日 1997-11-12 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase from a PCB degrader at 2.0 A resolution. Protein Sci., 7, 1998
6DTP	CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH EM139 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Estradiol 17-beta-dehydrogenase 1, ... 著者 Li, T, Lin, S.X. 登録日 2018-06-18 公開日 2018-09-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPLEXED WITH Dual-Site Inhibitor EM-139 Health, 2018
4IS3	Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution 分子名称: ACETATE ION, Bile acid 3-alpha hydroxysteroid dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Joint Center for Structural Genomics (JCSG) 登録日 2013-01-16 公開日 2013-04-24 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution To be published
3VZQ	Crystal structure of Q47L mutant of PhaB from Ralstonia eutropha 分子名称: Acetoacetyl-CoA reductase 著者 Ikeda, K, Tanaka, Y, Tanaka, I, Yao, M. 登録日 2012-10-15 公開日 2013-08-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A (Acetoacetyl-CoA) reductase from Ralstonia eutropha reveals two mutations responsible for enhanced kinetics Appl.Environ.Microbiol., 79, 2013
7N09	Structural basis for branched substrate selectivity in a ketoreductase from Ascaris suum 分子名称: 3-hydroxyacyl-CoA dehydrogenase type-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Dong, H, Chang, M.C.Y. 登録日 2021-05-25 公開日 2021-08-11 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for Branched Substrate Selectivity in a Ketoreductase from Ascaris suum Acs Catalysis, 11, 2021
3KZV	The crystal structure of a cytoplasmic protein with unknown function from Saccharomyces cerevisiae 分子名称: GLYCEROL, Uncharacterized oxidoreductase YIR035C 著者 Zhang, R, Xu, X, Cui, H, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-12-08 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of a cytoplasmic protein with unknown function from Saccharomyces cerevisiae To be Published
7BSX	SDR protein NapW-NADP 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase 著者 Wen, W.H, Tang, G.L. 登録日 2020-03-31 公開日 2021-10-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. Nat Commun, 12, 2021
3M1A	The Crystal Structure of a Short-chain Dehydrogenase from Streptomyces avermitilis to 2A 分子名称: ACETATE ION, Putative dehydrogenase, SODIUM ION 著者 Stein, A.J, Evdokimova, E, Egorova, O, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2010-03-04 公開日 2010-03-23 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Crystal Structure of a Short-chain Dehydrogenase from Streptomyces avermitilis to 2A To be Published
5IDW	Crystal structure of an oxidoreductase from Burkholderia vietnamiensis in complex with NADP 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-24 公開日 2016-03-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of an oxidoreductase from Burkholderia vietnamiensis in complex with NADP to be published
1U7T	Crystal Structure of ABAD/HSD10 with a Bound Inhibitor 分子名称: 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT, 3-hydroxyacyl-CoA dehydrogenase type II, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Kissinger, C.R, Rejto, P.A, Pelletier, L.A, Showalter, R.E, Villafranca, J.E. 登録日 2004-08-04 公開日 2004-10-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics J.Mol.Biol., 342, 2004
3HB5	Binary and ternary crystal structures of a novel inhibitor of 17 beta-HSD type 1: a lead compound for breast cancer therapy 分子名称: 3-{[(9beta,14beta,16alpha,17alpha)-3,17-dihydroxyestra-1,3,5(10)-trien-16-yl]methyl}benzamide, Estradiol 17-beta-dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Mazumdar, M, Lin, S.-X. 登録日 2009-05-04 公開日 2009-12-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy. Biochem.J., 424, 2009
5WQN	Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 (condition II) 分子名称: Probable dehydrogenase 著者 Li, S, Wang, Y, Bartlam, M. 登録日 2016-11-27 公開日 2017-10-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1. FEBS Lett., 591, 2017

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