PDB: 367 件ウェブページステータス検索Chemie searchBIRD

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6R46	Crystal structure of LPOR (Thermosynechococcus elongatus) complexed with NADP+ at 2.5A resolution 分子名称: CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH-protochlorophyllide oxidoreductase, ... 著者 Zhou, A, Feng, L. 登録日 2019-03-22 公開日 2019-10-30 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature, 574, 2019
2RHR	P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin 分子名称: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Korman, T.P, Tsai, S.-C. 登録日 2007-10-09 公開日 2008-08-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase Biochemistry, 47, 2008
3G49	N-(Pyridin-2-yl) Arylsulfonamide Inhibitors of 11b-Hydroxysteroid Dehydrogenase Type 1: Discovery of PF-915275 分子名称: 11-beta-hydroxysteroid dehydrogenase 1, 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Pauly, T.A. 登録日 2009-02-03 公開日 2009-08-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg.Med.Chem.Lett., 19, 2009
1Z6Z	Crystal Structure of Human Sepiapterin Reductase in complex with NADP+ 分子名称: CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... 著者 Ugochukwu, E, Kavanagh, K, Ng, S, Arrowsmith, C, Edwards, A, Sundstrom, M, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2005-03-23 公開日 2005-04-05 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of Human Sepiapterin Reductase To be Published
3SC4	Crystal structure of a Short chain dehydrogenase (A0QTM2 homolog) Mycobacterium thermoresistibile 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-06-06 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of a Short chain dehydrogenase (A0QTM2 homolog) Mycobacterium thermoresistibile To be Published
3D5Q	Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor 分子名称: 3-[1-(4-fluorophenyl)cyclopropyl]-4-(1-methylethyl)-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wang, Z, Liu, J, Sudom, A, Walker, N.P.C. 登録日 2008-05-16 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. Bioorg.Med.Chem., 16, 2008
4BB6	Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors 分子名称: 6-(4-methylpiperazin-1-yl)-N-[(1R,3S)-5-oxidanyl-2-adamantyl]-2-propylsulfanyl-pyridine-3-carboxamide, CHLORIDE ION, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, ... 著者 Goldberg, F.W, Leach, A.G, Scott, J.S, Snelson, W.L, Groombridge, S.D, Donald, C.S, Bennett, S.N.L, Bodin, C, Morentin Gutierrez, P, Gyte, A.C. 登録日 2012-09-20 公開日 2012-11-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Free-Wilson and Structural Approaches to Co- Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors J.Med.Chem., 55, 2012
7E3X	Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase 著者 Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S. 登録日 2021-02-09 公開日 2021-09-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technology, 2021
5WQM	Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 (condition I) 分子名称: Probable dehydrogenase, SODIUM ION 著者 Li, S, Wang, Y, Bartlam, M. 登録日 2016-11-27 公開日 2018-07-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1. FEBS Lett., 591, 2017
1DIR	CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER 分子名称: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Varughese, K.I, Su, Y, Skinner, M.M, Matthews, D.A, Whitely, J.M, Xuong, N.H. 登録日 1994-04-18 公開日 1994-07-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver. Acta Crystallogr.,Sect.D, 50, 1994
3D3E	Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Benzamide Inhibitor 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wang, Z, Sudom, A, Liu, J, Walker, N.P. 登録日 2008-05-09 公開日 2008-07-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of Novel, Potent Benzamide Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model J.Med.Chem., 51, 2008
7ULH	Crystal Structure of a Short chain dehydrogenase from Mycobacterium avium 104 分子名称: Short chain dehydrogenase 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-04-04 公開日 2022-04-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of Crystal Structure of a Short chain dehydrogenase from Mycobacterium avium 104 to be published
3OQ1	Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone Inhibitor 分子名称: 3-(2-fluoroethyl)-4-({4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]phenyl}sulfonyl)benzonitrile, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wang, Z, Sudom, A, Walker, N.P. 登録日 2010-09-02 公開日 2011-07-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The synthesis and SAR of novel diarylsulfone 11beta-HSD1 inhibitors Bioorg.Med.Chem.Lett., 20, 2010
4J7X	Crystal structure of human sepiapterin reductase in complex with sulfasalazine 分子名称: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Groenlund Pedersen, M, Pojer, F, Johnsson, K. 登録日 2013-02-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of human sepiapterin reductase in complex with sulfasalazine To be Published
3RKU	Substrate Fingerprint and the Structure of NADP+ Dependent Serine Dehydrogenase from Saccharomyces cerevisiae complexed with NADP+ 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase YMR226C 著者 Huether, R, Pacheco, C.M, Duax, W.L. 登録日 2011-04-18 公開日 2011-06-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Substrate Fingerprint and the Structure of NADP+ Dependent Serine Dehydrogenase from Saccharomyces cerevisiae complexed with NADP+ To be Published
3F1K	Crystal Structure of yciK from E. coli, an oxidoreductase, complexed with NADP+ at 2.6A resolution 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Uncharacterized oxidoreductase yciK 著者 Vijayalakshmi, J, Woodard, R.W. 登録日 2008-10-28 公開日 2008-11-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of an oxidoreductase, yciK from E. coli, in two crystal forms - NADP+ unbound structure at 0.95 A resolution to be published
1YO6	Crystal Structure of the putative Carbonyl Reductase Sniffer of Caenorhabditis elegans 分子名称: Putative Carbonyl Reductase Sniffer 著者 Southeast Collaboratory for Structural Genomics (SECSG) 登録日 2005-01-26 公開日 2005-02-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of the putative Carbonyl Reductase Sniffer of Caenorhabditis elegans To be Published
6NJ7	11-BETA DEHYDROGENASE ISOZYME 1 IN COMPLEX WITH COLLETOIC ACID 分子名称: (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl)spiro[4.5]dec-7-ene-1-carboxylic acid, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Miller, D.J, Rivas, F. 登録日 2019-01-02 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Mechanistic Insight on the Mode of Action of Colletoic Acid. J.Med.Chem., 62, 2019
4FD3	Crystal structure of apo-formed ymtOAR1 分子名称: 3-oxoacyl-[acyl-carrier-protein] reductase 著者 Zhang, Y, Gao, Y, Ning, F, Niu, L, Teng, M. 登録日 2012-05-26 公開日 2013-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of apo-formed ymtOAR1 To be Published
2HSD	THE REFINED THREE-DIMENSIONAL STRUCTURE OF 3ALPHA,20BETA-HYDROXYSTEROID DEHYDROGENASE AND POSSIBLE ROLES OF THE RESIDUES CONSERVED IN SHORT-CHAIN DEHYDROGENASES 分子名称: 3-ALPHA, 20 BETA-HYDROXYSTEROID DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Ghosh, D, Duax, W.L. 登録日 1994-03-28 公開日 1994-08-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 The refined three-dimensional structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases. Structure, 2, 1994
4DBZ	Crystal Structure of V151L Actinorhodin Polyketide Ketoreductase with NADPH 分子名称: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Javidpour, P, Tsai, S.-C. 登録日 2012-01-16 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.643 Å) 主引用文献 The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase. Chem.Biol., 20, 2013
8G9V	Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 分子名称: 17-beta-hydroxysteroid dehydrogenase 13, 4-{[2,5-dimethyl-3-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonyl]amino}benzoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Liu, S. 登録日 2023-02-22 公開日 2023-08-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.645 Å) 主引用文献 Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
4Y98	Crystal structure of LigD-apo form from Sphingobium sp. strain SYK-6 分子名称: C alpha-dehydrogenase 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.648 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
3FCO	Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Wang, Z, Sudom, A, Walker, N.P. 登録日 2008-11-21 公開日 2009-12-01 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
5QIJ	CRYSTAL STRUCTURE OF MURINE 11B- HYDROXYSTEROIDDEHYDROGENASE COMPLEXED WITH 2-(3-(1-(4- CHLOROPHENYL)CYCLOPROPYL)-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-8- YL)PROPAN-2-OL 分子名称: 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Sheriff, S. 登録日 2018-07-03 公開日 2018-12-19 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 9, 2018

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