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5QIJ

CRYSTAL STRUCTURE OF MURINE 11B- HYDROXYSTEROIDDEHYDROGENASE COMPLEXED WITH 2-(3-(1-(4- CHLOROPHENYL)CYCLOPROPYL)-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-8- YL)PROPAN-2-OL

Summary for 5QIJ
Entry DOI10.2210/pdb5qij/pdb
Group deposition11betaHSD1 (G_1002051)
DescriptorCorticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol, ... (5 entities in total)
Functional Keywords11b-hsd1, sdr, dehydrogenase, hydroxysteroid, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceMus musculus (Mouse)
Total number of polymer chains2
Total formula weight64641.84
Authors
Sheriff, S. (deposition date: 2018-07-03, release date: 2018-12-19, Last modification date: 2024-03-06)
Primary citationLi, J.,Kennedy, L.J.,Walker, S.J.,Wang, H.,Li, J.J.,Hong, Z.,O'Connor, S.P.,Ye, X.Y.,Chen, S.,Wu, S.,Yoon, D.S.,Nayeem, A.,Camac, D.M.,Ramamurthy, V.,Morin, P.E.,Sheriff, S.,Wang, M.,Harper, T.W.,Golla, R.,Seethala, R.,Harrity, T.,Ponticiello, R.P.,Morgan, N.N.,Taylor, J.R.,Zebo, R.,Maxwell, B.,Moulin, F.,Gordon, D.A.,Robl, J.A.
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1).
ACS Med Chem Lett, 9:1170-1174, 2018
Cited by
PubMed: 30613321
DOI: 10.1021/acsmedchemlett.8b00307
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

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