5QIJ
CRYSTAL STRUCTURE OF MURINE 11B- HYDROXYSTEROIDDEHYDROGENASE COMPLEXED WITH 2-(3-(1-(4- CHLOROPHENYL)CYCLOPROPYL)-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-8- YL)PROPAN-2-OL
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | polymer | 276 | 30585.7 | 2 | UniProt (P50172) Pfam (PF00106) | Mus musculus (Mouse) | 11-beta-hydroxysteroid dehydrogenase 1,11-beta-HSD1,11beta-HSD1A |
| 2 | C, J (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, I, K, L (A, B) | 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol | non-polymer | 327.8 | 4 | Chemie (HJG) | |||
| 4 | E, F, G, H, M... (A, B) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | P, Q (A, B) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 292 (UniProt: P50172)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| His 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61171.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3470.5 | |
| All* | Total formula weight | 64641.8 |
