1OK2
 
 | | Decay accelerating factor (CD55): the structure of an intact human complement regulator. | | Descriptor: | ACETATE ION, COMPLEMENT DECAY-ACCELERATING FACTOR, GLYCEROL, ... | | Authors: | Lukacik, P, Roversi, P, White, J, Esser, D, Smith, G.P, Billington, J, Williams, P.A, Rudd, P.M, Wormald, M.R, Crispin, M.D.M, Radcliffe, C.M, Dwek, R.A, Evans, D.J, Morgan, B.P, Smith, R.A.G, Lea, S.M. | | Deposit date: | 2003-07-16 | | Release date: | 2004-01-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Complement Regulation at the Molecular Level: The Structure of Decay-Accelerating Factor
Proc.Natl.Acad.Sci.USA, 101, 2004
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1PPQ
 | | NMR structure of 16th module of Immune Adherence Receptor, Cr1 (Cd35) | | Descriptor: | Complement receptor type 1 | | Authors: | O'Leary, J.M, Bromek, K, Black, G.M, Uhrinova, S, Schmitz, C, Krych, M, Atkinson, J.P, Uhrin, D, Barlow, P.N. | | Deposit date: | 2003-06-17 | | Release date: | 2004-05-04 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces.
Protein Sci., 13, 2004
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1SS2
 | | Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer | | Descriptor: | Gamma-aminobutyric acid type B receptor, subunit 1 | | Authors: | Blein, S, Uhrin, D, Smith, B.O, White, J.H, Barlow, P.N. | | Deposit date: | 2004-03-23 | | Release date: | 2004-10-12 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded.
J.Biol.Chem., 279, 2004
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1SRZ
 | | Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 trans conformer | | Descriptor: | Gamma-aminobutyric acid type B receptor, subunit 1 | | Authors: | Blein, S, Uhrin, D, Smith, B.O, White, J.H, Barlow, P.N. | | Deposit date: | 2004-03-23 | | Release date: | 2004-10-12 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural Analysis of the Complement Control Protein (CCP) Modules of GABAB Receptor 1a: ONLY ONE OF THE TWO CCP MODULES IS COMPACTLY FOLDED
J.Biol.Chem., 279, 2004
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2Q7Z
 | | Solution Structure of the 30 SCR domains of human Complement Receptor 1 | | Descriptor: | Complement receptor type 1 | | Authors: | Furtado, P.B, Huang, C.Y, Ihyembe, D, Hammond, R.A, Marsh, H.C, Perkins, S.J. | | Deposit date: | 2007-06-08 | | Release date: | 2007-10-16 | | Last modified: | 2024-02-21 | | Method: | SOLUTION SCATTERING | | Cite: | The Partly Folded Back Solution Structure Arrangement of the 30 SCR Domains in Human Complement Receptor Type 1 (CR1) Permits Access to its C3b and C4b Ligands
J.Mol.Biol., 375, 2008
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2QFG
 | | Solution Structure of the N-terminal SCR-1/5 fragment of Complement Factor H. | | Descriptor: | Complement factor H | | Authors: | Okemefuna, A.I, Gilbert, H.E, Griggs, K.M, Ormsby, R.J, Gordon, D.L, Perkins, S.J. | | Deposit date: | 2007-06-27 | | Release date: | 2007-09-25 | | Last modified: | 2024-02-21 | | Method: | SOLUTION SCATTERING | | Cite: | The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties.
J.Mol.Biol., 375, 2008
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2QZH
 | | SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF | | Descriptor: | Complement decay-accelerating factor | | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | | Deposit date: | 2007-08-16 | | Release date: | 2007-10-30 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
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2QZF
 | | SCR1 of DAF from 1ojv fitted into cryoEM density | | Descriptor: | Complement decay-accelerating factor | | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | | Deposit date: | 2007-08-16 | | Release date: | 2007-10-30 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
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2QFH
 | | Solution Structure of the C-terminal SCR-16/20 fragment of Complement Factor H. | | Descriptor: | Complement factor H | | Authors: | Okemefuna, A.I, Gilbert, H.E, Griggs, K.M, Ormsby, R.J, Gordon, D.L, Perkins, S.J. | | Deposit date: | 2007-06-27 | | Release date: | 2007-09-25 | | Last modified: | 2024-02-21 | | Method: | SOLUTION SCATTERING | | Cite: | The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties.
J.Mol.Biol., 375, 2008
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2QZD
 | | Fitted structure of SCR4 of DAF into cryoEM density | | Descriptor: | Complement decay-accelerating factor | | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | | Deposit date: | 2007-08-16 | | Release date: | 2007-10-30 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
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2RLQ
 | | NMR structure of CCP modules 2-3 of complement factor H | | Descriptor: | Complement factor H | | Authors: | Hocking, H.G, Herbert, A.P, Pangburn, M.K, Kavanagh, D, Barlow, P.N, Uhrin, D. | | Deposit date: | 2007-07-29 | | Release date: | 2008-02-19 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
J.Biol.Chem., 283, 2008
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2RLP
 | | NMR structure of CCP modules 1-2 of complement factor H | | Descriptor: | Complement factor H | | Authors: | Hocking, H.G, Herbert, A.P, Pangburn, M.K, Kavanagh, D, Barlow, P.N, Uhrin, D. | | Deposit date: | 2007-07-28 | | Release date: | 2008-02-19 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
J.Biol.Chem., 283, 2008
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2UWN
 | | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. | | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | | Authors: | Prosser, B.E, Johnson, S, Roversi, P, Herbert, A.P, Blaum, B.S, Tyrrell, J, Jowitt, T.A, Clark, S.J, Terelli, E, Uhrin, D, Barlow, P.N, Sim, R.B, Day, A.J, Lea, S.M. | | Deposit date: | 2007-03-22 | | Release date: | 2007-10-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
J.Exp.Med., 204, 2007
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2V8E
 | | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. | | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CHLORIDE ION, COMPLEMENT FACTOR H, ... | | Authors: | Prosser, B.E, Johnson, S, Roversi, P, Herbert, A.P, Blaum, B.S, Tyrrell, J, Jowitt, T.A, Clark, S.J, Tarelli, E, Uhrin, D, Barlow, P.N, Sim, R.B, Day, A.J, Lea, S.M. | | Deposit date: | 2007-08-07 | | Release date: | 2007-10-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
J.Exp.Med., 204, 2007
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5JPM
 | | Structure of the complex of human complement C4 with MASP-2 rebuilt using iMDFF | | Descriptor: | Complement C4-A, Mannan-binding lectin serine protease 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Croll, T.I, Andersen, G.R. | | Deposit date: | 2016-05-03 | | Release date: | 2016-08-10 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.75 Å) | | Cite: | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
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4ZH1
 | | Complement factor H in complex with the GM1 glycan | | Descriptor: | Complement C3, Complement factor H, GLYCEROL, ... | | Authors: | Blaum, B.S, Stehle, T. | | Deposit date: | 2015-04-24 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
Glycobiology, 26, 2016
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5UBM
 | | Crystal structure of human C1s in complex with inhibitor gigastasin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C1s subcomponent, Gigastasin | | Authors: | Pang, S.S, Whisstock, J.C. | | Deposit date: | 2016-12-20 | | Release date: | 2017-11-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.
J. Immunol., 199, 2017
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7UFG
 | | Cryo-EM structure of PAPP-A in complex with IGFBP5 | | Descriptor: | Insulin-like growth factor-binding protein 5, Pappalysin-1, ZINC ION | | Authors: | Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D. | | Deposit date: | 2022-03-22 | | Release date: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Nat Commun, 13, 2022
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5WTB
 | | Complex Structure of Staphylococcus aureus SdrE with human complement factor H | | Descriptor: | Peptide from Complement factor H, Serine-aspartate repeat-containing protein E | | Authors: | Wu, M, Zhang, Y, Hang, T, Wang, C, Yang, Y, Zang, J, Zhang, M, Zhang, X. | | Deposit date: | 2016-12-10 | | Release date: | 2017-07-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion
Biochem. J., 474, 2017
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1ELV
 | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE | | Descriptor: | 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C1S COMPONENT, ... | | Authors: | Gaboriaud, C, Rossi, V, Bally, I, Arlaud, G, Fontecilla-Camps, J.-C. | | Deposit date: | 2000-03-14 | | Release date: | 2001-03-14 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle.
EMBO J., 19, 2000
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4ONT
 | | Ternary host recognition complex of complement factor H, C3d, and sialic acid | | Descriptor: | Complement C3d fragment, Complement factor H, GLYCEROL, ... | | Authors: | Blaum, B.S, Stehle, T.S. | | Deposit date: | 2014-01-29 | | Release date: | 2014-11-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural basis for sialic acid-mediated self-recognition by complement factor H.
Nat.Chem.Biol., 11, 2015
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1C1Z
 | | CRYSTAL STRUCTURE OF HUMAN BETA-2-GLYCOPROTEIN-I (APOLIPOPROTEIN-H) | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, BETA2-GLYCOPROTEIN-I, ... | | Authors: | Schwarzenbacher, R, Zeth, K, Diederichs, K, Gries, A, Kostner, G.M, Laggner, P, Prassl, R. | | Deposit date: | 1999-07-22 | | Release date: | 1999-11-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome.
EMBO J., 18, 1999
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7KG4
 | | Recombinant Beta-2-Glycoprotein I antibody recognition loop mutant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Klenotic, P.A, Yu, E.W. | | Deposit date: | 2020-10-15 | | Release date: | 2021-10-20 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Beta-2-Glycoprotein I and its role in APS
To be published
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5NBQ
 | | The structure of the tripartite complex between OspE, the C-terminal domains of factor H and C3dg | | Descriptor: | Complement C3, Complement factor H, Outer surface protein E, ... | | Authors: | Kolodziejczyk, R, Mikula, K.M, Kotila, T.M, Postis, V.L.G, Sakari, J.T, Meri, T. | | Deposit date: | 2017-03-02 | | Release date: | 2017-12-06 | | Last modified: | 2017-12-13 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi.
PLoS ONE, 12, 2017
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8D8O
 | | Cryo-EM structure of substrate unbound PAPP-A | | Descriptor: | Pappalysin-1, ZINC ION | | Authors: | Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D. | | Deposit date: | 2022-06-08 | | Release date: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Nat Commun, 13, 2022
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