7QXS
 
 | | Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains) | | Descriptor: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | Authors: | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | Deposit date: | 2022-01-27 | | Release date: | 2022-03-02 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (3.91 Å) | | Cite: | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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7QXB
 | | Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map) | | Descriptor: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | Authors: | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | Deposit date: | 2022-01-26 | | Release date: | 2022-03-02 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (3.91 Å) | | Cite: | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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7QXA
 | | Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened) | | Descriptor: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | Authors: | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | Deposit date: | 2022-01-26 | | Release date: | 2022-03-02 | | Last modified: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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5G2X
 | | Structure a of Group II Intron Complexed with its Reverse Transcriptase | | Descriptor: | 5'-R(*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*CP)-3', GROUP II INTRON, GROUP II INTRON-ENCODED PROTEIN LTRA | | Authors: | Qu, G, Kaushal, P.S, Wang, J, Shigematsu, H, Piazza, C.L, Agrawal, R.K, Belfort, M, Wang, H.W. | | Deposit date: | 2016-04-16 | | Release date: | 2016-05-11 | | Last modified: | 2016-06-22 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of a Group II Intron in Complex with its Reverse Transcriptase.
Nat.Struct.Mol.Biol., 23, 2016
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4KSE
 | | Crystal structure of a HIV p51 (219-230) deletion mutant | | Descriptor: | 1,2-ETHANEDIOL, HIV p51 subunit | | Authors: | Zheng, X, Mueller, G.A, Derose, E.F, Pedersen, L.C, Gabel, S.A, Cuneo, M.J, Krahn, J.M, London, R.E. | | Deposit date: | 2013-05-17 | | Release date: | 2014-08-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.677 Å) | | Cite: | Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation.
Nucleic Acids Res., 42, 2014
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3DU5
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3DU6
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7KFU
 | | Cas6-RT-Cas1--Cas2 complex | | Descriptor: | Cas2, Cas6-RT-Cas1 | | Authors: | Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G. | | Deposit date: | 2020-10-14 | | Release date: | 2021-03-31 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
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7KFT
 | | Partial Cas6-RT-Cas1--Cas2 complex | | Descriptor: | Cas2, Cas6-RT-Cas1 | | Authors: | Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G. | | Deposit date: | 2020-10-14 | | Release date: | 2021-03-31 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
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7K9Y
 | | GsI-IIC RT Template-Switching Complex (twinned) | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*TP*CP*CP*AP*GP*GP*CP*AP*AP*C)-3'), MAGNESIUM ION, ... | | Authors: | Stamos, J.L, Lentzsch, A.M. | | Deposit date: | 2020-09-29 | | Release date: | 2021-08-18 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis for template switching by a group II intron-encoded non-LTR-retroelement reverse transcriptase.
J.Biol.Chem., 297, 2021
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7KQM
 | | Binary complex of TERT (telomerase reverse transcriptase) with RNA/telomeric DNA hybrid | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*GP*CP*AP*CP*CP*TP*G)-3'), ... | | Authors: | Choi, W.S, Weng, P.J, Yang, W. | | Deposit date: | 2020-11-17 | | Release date: | 2022-03-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Flexibility of telomerase in binding the RNA template and DNA telomeric repeat.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7KQN
 | | Ternary complex of TERT (telomerase reverse transcriptase) with RNA template, DNA primer, an incoming dGTP and a downstream hybrid duplex | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Choi, W.S, Weng, P.J, Yang, W. | | Deposit date: | 2020-11-17 | | Release date: | 2022-03-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Flexibility of telomerase in binding the RNA template and DNA telomeric repeat.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7TRF
 | | Human telomerase catalytic core RNP with H2A/H2B | | Descriptor: | Histone H2A, Histone H2B type 1-C/E/F/G/I, Telomerase RNA, ... | | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | | Deposit date: | 2022-01-28 | | Release date: | 2022-04-20 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
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7TRD
 | | Human telomerase catalytic core structure at 3.3 Angstrom | | Descriptor: | Telomerase RNA, partial sequence, Telomerase reverse transcriptase, ... | | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | | Deposit date: | 2022-01-28 | | Release date: | 2022-04-20 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
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7TRE
 | | Human telomerase catalytic core with shelterin protein TPP1 | | Descriptor: | Adrenocortical dysplasia protein homolog, Telomerase RNA, partial sequence, ... | | Authors: | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | | Deposit date: | 2022-01-28 | | Release date: | 2022-04-20 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
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7UIM
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7UIN
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7V99
 | | catalytic core of human telomerase holoenzyme | | Descriptor: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | | Authors: | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | | Deposit date: | 2021-08-24 | | Release date: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
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3KYL
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6USO
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6USP
 | | Telomerase Reverse Transcriptase product complex, TERT:DNA | | Descriptor: | DNA (5'-D(P*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ... | | Authors: | Schaich, M.A, Freudenthal, B.D. | | Deposit date: | 2019-10-28 | | Release date: | 2020-06-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.56 Å) | | Cite: | Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
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6USQ
 | | Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA | | Descriptor: | DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ... | | Authors: | Schaich, M.A, Freudenthal, B.D, Khoang, T.H. | | Deposit date: | 2019-10-28 | | Release date: | 2020-06-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.62 Å) | | Cite: | Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
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6USR
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6AR1
 | | Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications (RT/Duplex (Nat)) | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA, GsI-IIC RT, ... | | Authors: | Stamos, J.L, Lentzsch, A.M, Lambowitz, A.M. | | Deposit date: | 2017-08-21 | | Release date: | 2017-11-29 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications.
Mol. Cell, 68, 2017
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6AR3
 | | Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications (RT/Duplex (Se-Met)) | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA, GsI-IIC RT, ... | | Authors: | Stamos, J.L, Lentzsch, A.M, Lambowitz, A.M. | | Deposit date: | 2017-08-21 | | Release date: | 2017-11-29 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications.
Mol. Cell, 68, 2017
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