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5KW6
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BU of 5kw6 by Molmil
Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base
Descriptor: DNA (30-MER), Poly(U)-binding-splicing factor PUF60
Authors:Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T.
Deposit date:2016-07-15
Release date:2017-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.
Plos One, 15, 2020
5LSO
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BU of 5lso by Molmil
Crystal structure of SPF45 UHM domain with cyclic peptide inhibitor
Descriptor: LYS-SER-ARG-TRP-ASP-GLU, Splicing factor 45
Authors:Jagtap, P.K.A, Garg, D, Sattler, M.
Deposit date:2016-09-05
Release date:2016-10-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing.
J. Med. Chem., 59, 2016
5MPG
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BU of 5mpg by Molmil
Solution NMR structure of hnRNP A1 RRM1 in complex with 5'-UUAGGUC-3' RNA
Descriptor: Heterogeneous nuclear ribonucleoprotein A1, RNA UUAGGUC
Authors:Barraud, P, Allain, F.H.-T.
Deposit date:2016-12-16
Release date:2017-07-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7.
Elife, 6, 2017
5MPL
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BU of 5mpl by Molmil
hnRNP A1 RRM2 in complex with 5'-UCAGUU-3' RNA
Descriptor: Heterogeneous nuclear ribonucleoprotein A1, RNA UCAGUU
Authors:Barraud, P, Allain, F.H.-T.
Deposit date:2016-12-16
Release date:2017-07-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7.
Elife, 6, 2017
5M8I
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BU of 5m8i by Molmil
Solution structure of CUG-BP2 RRM3 in complex with 5'-UUUAA-3' RNA
Descriptor: CUGBP Elav-like family member 2, RNA (5'-R(*UP*UP*UP*AP*A)-3')
Authors:Diarra dit Konte, N, Damberger, F.F, Allain, F.H.T.
Deposit date:2016-10-28
Release date:2017-10-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination.
Nat Commun, 8, 2017
2OSR
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BU of 2osr by Molmil
NMR Structure of RRM-2 of Yeast NPL3 Protein
Descriptor: Nucleolar protein 3
Authors:Deka, P, Bucheli, M, Skrisovska, L, Allain, F.H, Moore, C, Buratowski, S, Varani, G.
Deposit date:2007-02-06
Release date:2007-12-18
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.
J.Mol.Biol., 375, 2008
6Z29
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BU of 6z29 by Molmil
Structure of eIF4G1 (37-49) - PUB1 RRM3 chimera in solution
Descriptor: Eukaryotic initiation factor 4F subunit p150,Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
Authors:Chaves-Arquero, B, Martinez-Lumbreras, S, Perez-Canadillas, J.M.
Deposit date:2020-05-15
Release date:2021-05-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly.
Front Mol Biosci, 9, 2022
2PEH
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BU of 2peh by Molmil
Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5
Descriptor: Splicing factor 3B subunit 1, Splicing factor 45
Authors:Corsini, L, Basquin, J, Hothorn, M, Sattler, M.
Deposit date:2007-04-03
Release date:2007-06-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
Nat.Struct.Mol.Biol., 14, 2007
2PE8
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BU of 2pe8 by Molmil
Crystal structure of the UHM domain of human SPF45 (free form)
Descriptor: Splicing factor 45
Authors:Corsini, L, Basquin, J, Hothorn, M, Sattler, M.
Deposit date:2007-04-02
Release date:2007-06-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
Nat.Struct.Mol.Biol., 14, 2007
2OSQ
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BU of 2osq by Molmil
NMR Structure of RRM-1 of Yeast NPL3 Protein
Descriptor: Nucleolar protein 3
Authors:Deka, P, Bucheli, M, Skrisovska, L, Allain, F.H, Moore, C, Buratowski, S, Varani, G.
Deposit date:2007-02-06
Release date:2007-12-18
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.
J.Mol.Biol., 375, 2008
7AAO
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BU of 7aao by Molmil
Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
Descriptor: U2 snRNP auxiliary factor large subunit
Authors:Kawale, A.A, Kang, H.S, Sattler, M.
Deposit date:2020-09-04
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
To Be Published
7AAF
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BU of 7aaf by Molmil
Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
Descriptor: U2 snRNP auxiliary factor large subunit
Authors:Kawale, A.A, Kang, H.S, Sattler, M.
Deposit date:2020-09-04
Release date:2021-10-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
To Be Published
7AEP
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BU of 7aep by Molmil
Solution structure of U1-A RRM2 (190-282)
Descriptor: U1 small nuclear ribonucleoprotein A
Authors:Campagne, S, Allain, F.H.
Deposit date:2020-09-18
Release date:2021-02-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands.
Nucleic Acids Res., 49, 2021
2QFJ
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BU of 2qfj by Molmil
Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE
Descriptor: DNA (5'-D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DTP*DGP*DTP*DGP*DTP*DTP*DAP*DTP*DT)-3'), FBP-interacting repressor
Authors:Crichlow, G.V, Yang, Y, Fan, C, Lolis, E, Braddock, D.
Deposit date:2007-06-27
Release date:2008-03-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition
EMBO J., 27, 2007
2RNE
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BU of 2rne by Molmil
Solution structure of the second RNA recognition motif (RRM) of TIA-1
Descriptor: Tia1 protein
Authors:Takahashi, M, Kuwasako, K, Abe, C, Tsuda, K, Inoue, M, Terada, T, Shirouzu, M, Kobayashi, N, Kigawa, T, Taguchi, S, Guntert, P, Hayashizaki, Y, Tanaka, A, Muto, Y, Yokoyama, S.
Deposit date:2007-12-19
Release date:2008-11-04
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode
Biochemistry, 47, 2008
2RS8
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BU of 2rs8 by Molmil
Solution structure of the N-terminal RNA recognition motif of NonO
Descriptor: Non-POU domain-containing octamer-binding protein
Authors:Nagata, T, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2011-11-29
Release date:2012-12-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure of the N-terminal RNA recognition motif of NonO
To be Published
2RRA
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BU of 2rra by Molmil
Solution structure of RNA binding domain in human Tra2 beta protein in complex with RNA (GAAGAA)
Descriptor: 5'-R(*GP*AP*AP*GP*AP*A)-3', cDNA FLJ40872 fis, clone TUTER2000283, ...
Authors:Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2010-06-17
Release date:2011-04-27
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM.
Nucleic Acids Res., 39, 2011
2RS2
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BU of 2rs2 by Molmil
1H, 13C, and 15N Chemical Shift Assignments for Musashi1 RBD1:r(GUAGU) complex
Descriptor: RNA (5'-R(*GP*UP*AP*GP*U)-3'), RNA-binding protein Musashi homolog 1
Authors:Ohyama, T, Nagata, T, Tsuda, K, Imai, T, Okano, H, Yamazaki, T, Katahira, M.
Deposit date:2011-06-27
Release date:2011-12-28
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions
Nucleic Acids Res., 2011
2RQ4
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BU of 2rq4 by Molmil
Refinement of RNA binding domain 3 in CUG triplet repeat RNA-binding protein 1
Descriptor: CUG-BP- and ETR-3-like factor 1
Authors:Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Terada, T, Kobayashi, N, Shirouzu, M, Kigawa, T, Guntert, P, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2009-01-19
Release date:2009-08-04
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3
Nucleic Acids Res., 2009
2UP1
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BU of 2up1 by Molmil
STRUCTURE OF UP1-TELOMERIC DNA COMPLEX
Descriptor: DNA (5'-D(P*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), PROTEIN (HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1)
Authors:Ding, J, Hayashi, M.K, Krainer, A.R, Xu, R.-M.
Deposit date:1998-07-10
Release date:1999-11-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA.
Genes Dev., 13, 1999
7CSZ
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BU of 7csz by Molmil
Crystal structure of the N-terminal tandem RRM domains of RBM45 in complex with single-stranded DNA
Descriptor: DNA (5'-D(*CP*GP*AP*CP*GP*GP*GP*AP*CP*GP*C)-3'), RNA-binding protein 45
Authors:Chen, X, Yang, Z, Wang, W, Wang, M.
Deposit date:2020-08-17
Release date:2021-02-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45.
Nucleic Acids Res., 49, 2021
2SXL
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BU of 2sxl by Molmil
SEX-LETHAL RBD1, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: SEX-LETHAL PROTEIN
Authors:Inoue, M, Muto, Y, Sakamoto, H, Kigawa, T, Takio, K, Shimura, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1997-07-16
Release date:1998-07-22
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:A characteristic arrangement of aromatic amino acid residues in the solution structure of the amino-terminal RNA-binding domain of Drosophila sex-lethal.
J.Mol.Biol., 272, 1997
7CSX
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BU of 7csx by Molmil
Crystal structure of the N-terminal tandem RRM domains of RBM45
Descriptor: RNA-binding protein 45
Authors:Chen, X, Yang, Z, Wang, W, Wang, M.
Deposit date:2020-08-17
Release date:2021-02-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45.
Nucleic Acids Res., 49, 2021
2RQC
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BU of 2rqc by Molmil
Solution Structure of RNA-binding domain 3 of CUGBP1 in complex with RNA (UG)3
Descriptor: 5'-R(*UP*GP*UP*GP*UP*G)-3', CUG-BP- and ETR-3-like factor 1
Authors:Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2009-04-09
Release date:2009-08-04
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3
Nucleic Acids Res., 37, 2009
2RRB
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BU of 2rrb by Molmil
Refinement of RNA binding domain in human Tra2 beta protein
Descriptor: cDNA FLJ40872 fis, clone TUTER2000283, highly similar to Homo sapiens transformer-2-beta (SFRS10) gene
Authors:Tsuda, K, Kuwasako, K, Takahashi, M, Someya, T, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Sugano, S, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2010-06-17
Release date:2011-04-27
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM.
Nucleic Acids Res., 39, 2011

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