PDB: 1327 件ウェブページステータス検索Chemie searchBIRD

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8AZZ	KRAS-G12V in complex with BI-2865 分子名称: (4S)-2-azanyl-4-methyl-4-[3-[4-[(1S)-1-[(2S)-1-methylpyrrolidin-1-ium-2-yl]ethoxy]pyrimidin-2-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... 著者 Boettcher, J, Herdeis, L. 登録日 2022-09-06 公開日 2023-06-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.02 Å) 主引用文献 Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
2L0X	Solution structure of the 21 kDa GTPase RHEB bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Stoll, R, Heumann, R, Berghaus, C, Kock, G. 登録日 2010-07-19 公開日 2010-08-04 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J.Biol.Chem., 285, 2010
8B6I	KRasG12C ligand complex 分子名称: 1-[(4~{a}~{S})-7-chloranyl-8-(5-methyl-2~{H}-indazol-4-yl)-1,2,4,4~{a},5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Phillips, C, Breed, J. 登録日 2022-09-27 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration. J.Med.Chem., 66, 2023
6QUU	Crystal Structure of KRAS-G12D in complex with GMP-PCP 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.477 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
6QUV	Crystal Structure of KRAS-G12D in complex with GMP-PCP and compound 15R 分子名称: (6~{a}~{R},11~{b}~{S})-6~{a}-(1,4-dimethylpiperidin-4-yl)-7,11~{b}-dihydro-6~{H}-indolo[2,3-c]isoquinolin-5-one, GTPase KRas, MAGNESIUM ION, ... 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.475 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
6QUX	Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 15 分子名称: (6~{a}~{R},11~{b}~{S})-6~{a}-(1,4-dimethylpiperidin-4-yl)-7,11~{b}-dihydro-6~{H}-indolo[2,3-c]isoquinolin-5-one, 1,2-ETHANEDIOL, GTPase KRas, ... 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
1GWN	The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho-related GTP-binding protein RhoE 著者 Garavini, H, Riento, K, Phelan, J.P, McAlister, M.S.B, Ridley, A.J, Keep, N.H. 登録日 2002-03-19 公開日 2002-04-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the Core Domain of Rhoe/Rnd3: A Constitutively Activated Small G Protein Biochemistry, 41, 2002
8IJ9	Crystal structure of the ELKS1/Rab6B complex 分子名称: ELKS/Rab6-interacting/CAST family member 1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Jin, G, Wei, Z. 登録日 2023-02-26 公開日 2023-06-14 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural basis of ELKS/Rab6B interaction and its role in vesicle capturing enhanced by liquid-liquid phase separation. J.Biol.Chem., 299, 2023
1GNR	X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP 分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION 著者 Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. 登録日 1995-05-11 公開日 1995-07-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
1GNQ	X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP 分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION 著者 Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. 登録日 1995-05-11 公開日 1995-07-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
1GNP	X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP 分子名称: C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID 3'-O-(N-METHYLANTHRANILOYL-2'-DEOXYGUANYLATE ESTER 著者 Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. 登録日 1995-05-11 公開日 1995-07-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
6QUW	Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 9b 分子名称: (3~{a}~{R},8~{b}~{S})-2,2,3~{a},8~{b}-tetramethyl-3,4-dihydro-1~{H}-pyrrolo[2,3-b]indole, GTPase KRas, MAGNESIUM ION, ... 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.242 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
1HUQ	1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE) 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB5C 著者 Merithew, E, Hatherly, S, Dumas, J.J, Lawe, D.C, Heller-Harrison, R, Lambright, D.G. 登録日 2001-01-04 公開日 2001-02-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. J.Biol.Chem., 276, 2001
8B78	KRasG12C ligand complex 分子名称: 1-[(4~{a}~{R})-8-(2-chloranyl-6-oxidanyl-phenyl)-7-fluoranyl-9-prop-1-ynyl-1,2,4,4~{a},5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Phillips, C, Breed, J. 登録日 2022-09-29 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration. J.Med.Chem., 66, 2023
2LWI	Solution structure of H-RasT35S mutant protein in complex with Kobe2601 分子名称: 2-(2,4-dinitrophenyl)-N-(4-fluorophenyl)hydrazinecarbothioamide, GTPase HRas, MAGNESIUM ION, ... 著者 Araki, M, Tamura, A, Shima, F, Kataoka, T. 登録日 2012-08-01 公開日 2013-05-22 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.USA, 110, 2013
1IAQ	C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, TRANSFORMING PROTEIN P21/H-RAS-1 著者 Spoerner, M, Herrmann, C, Vetter, I.R, Kalbitzer, H.R, Wittinghofer, A. 登録日 2001-03-23 公開日 2001-06-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc.Natl.Acad.Sci.USA, 98, 2001
8BWG	HRas (1-166) Y64 phosphorylation 分子名称: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Baumann, P, Jin, Y. 登録日 2022-12-06 公開日 2023-09-27 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Far-reaching effects of tyrosine64 phosphorylation on Ras revealed with BeF 3 - complexes. Commun Chem, 7, 2024
2MMC	Nucleotide-free human ran gtpase 分子名称: GTP-binding nuclear protein Ran 著者 Bacot-Davis, V.R, Palmenberg, A.C. 登録日 2014-03-13 公開日 2014-10-22 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Nuclear Magnetic Resonance Structure of Ran GTPase Determines C-terminal Tail Conformational Dynamics. To be Published
2MMG	Structural Characterization of the Mengovirus Leader Protein Bound to Ran GTPase by Nuclear Magnetic Resonance 分子名称: GTP-binding nuclear protein Ran 著者 Bacot-Davis, V.R, Palmenberg, A.C, Cornilescu, C.C, Markley, J.L. 登録日 2014-03-15 公開日 2014-10-15 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase. Proc.Natl.Acad.Sci.USA, 111, 2014
1IOZ	Crystal Structure of the C-HA-RAS Protein Prepared by the Cell-Free Synthesis 分子名称: GUANOSINE-5'-DIPHOSPHATE, TRANSFORMING PROTEIN P21/H-RAS-1 著者 Kigawa, T, Yamaguchi-Nunokawa, E, Kodama, K, Matsuda, T, Yabuki, T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2001-04-18 公開日 2001-10-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Selenomethionine incorporation into a protein by cell-free synthesis J.STRUCT.FUNCT.GENOM., 2, 2001
2N42	EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data 分子名称: GTPase HRas 著者 Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2015-06-16 公開日 2015-07-01 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Protein structure determination by combining sparse NMR data with evolutionary couplings. Nat.Methods, 12, 2015
2N46	EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data 分子名称: GTPase HRas 著者 Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2015-06-17 公開日 2015-07-01 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Protein structure determination by combining sparse NMR data with evolutionary couplings. Nat.Methods, 12, 2015
2N1B	NMR solution structure of nucleotide-free Ran GTPase 分子名称: GTP-binding nuclear protein Ran 著者 Bacot-Davis, V.R, Palmenberg, A.C. 登録日 2015-03-26 公開日 2016-04-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NMR Structure of Ran GTPase Determines C-terminal Tail Conformational Dynamics. To be Published
1JAI	H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MANGANESE 分子名称: C-HA-RAS, MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Schweins, T, Scheffzek, K, Assheuer, R, Wittinghofer, A. 登録日 1996-12-15 公開日 1997-07-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. J.Mol.Biol., 266, 1997
2O52	Crystal structure of human RAB4B in complex with GDP 分子名称: BETA-MERCAPTOETHANOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Zhu, H, Tempel, W, Wang, J, Shen, Y, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2006-12-05 公開日 2006-12-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of human RAB4B in complex with GDP To be Published

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