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1SD3
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Crystal structure of the GLUR6 ligand binding core in complex with 2S,4R-4-methylglutamate at 1.8 Angstrom resolution
Descriptor: 2S,4R-4-METHYLGLUTAMATE, Glutamate receptor, ionotropic kainate 2
Authors:Mayer, M.L.
Deposit date:2004-02-12
Release date:2005-02-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.
Neuron, 45, 2005
1SYI
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X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION.
Descriptor: (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID, Glutamate receptor 2
Authors:Frandsen, A, Pickering, D.S, Vestergaard, B, Kasper, C, Nielsen, B.B, Greenwood, J.R, Campiani, G, Gajhede, M, Schousboe, A, Kastrup, J.S.
Deposit date:2004-04-01
Release date:2005-03-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
Mol.Pharmacol., 67, 2005
1SYH
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION.
Descriptor: (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID, Glutamate receptor 2
Authors:Frandsen, A, Pickering, D.S, Vestergaard, B, Kasper, C, Nielsen, B.B, Greenwood, J.R, Campiani, G, Gajhede, M, Schousboe, A, Kastrup, J.S.
Deposit date:2004-04-01
Release date:2005-03-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
Mol.Pharmacol., 67, 2005
1TT1
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CRYSTAL STRUCTURE OF THE GLUR6 LIGAND BINDING CORE IN COMPLEX WITH KAINATE 1.93 A RESOLUTION
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor, ionotropic kainate 2
Authors:Mayer, M.L.
Deposit date:2004-06-21
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structures of the GluR5 and GluR6 ligand binding cores: Molecular mechanisms underlying kainate receptor selectivity
Neuron, 45, 2005
1TXF
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CRYSTAL STRUCTURE OF THE GLUR5 LIGAND BINDING CORE IN COMPLEX WITH GLUTAMATE AT 2.1 ANGSTROM RESOLUTION
Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 1
Authors:Mayer, M.L.
Deposit date:2004-07-04
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the GluR5 and GluR6 ligand binding cores: Molecular mechanisms underlying kainate receptor selectivity
Neuron, 45, 2005
1XHY
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BU of 1xhy by Molmil
X-ray structure of the Y702F mutant of the GluR2 ligand-binding core (S1S2J) in complex with kainate at 1.85 A resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor, SULFATE ION
Authors:Frandsen, A, Pickering, D.S, Vestergaard, B, Kasper, C, Nielsen, B.B, Greenwood, J.R, Campiani, G, Gajhede, M, Schousboe, A, Kastrup, J.S.
Deposit date:2004-09-21
Release date:2005-03-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
Mol.Pharmacol., 67, 2005
1Y1M
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Crystal structure of the NR1 ligand binding core in complex with cycloleucine
Descriptor: 1-AMINOCYCLOPENTANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
Authors:Inanobe, A, Gouaux, E.
Deposit date:2004-11-18
Release date:2005-07-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1Y20
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Crystal structure of the NR1 ligand-binding core in complex with ACPC
Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
Authors:Inanobe, A, Gouaux, E.
Deposit date:2004-11-19
Release date:2005-07-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1Y1Z
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Crystal structure of the NR1 ligand binding core in complex with ACBC
Descriptor: 1-AMINOCYCLOBUTANECARBOXLIC ACID, Glutamate [NMDA] receptor subunit zeta 1
Authors:Inanobe, A, Gouaux, E.
Deposit date:2004-11-19
Release date:2005-07-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors.
Neuron, 47, 2005
1WVJ
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Exploring the GluR2 ligand-binding core in complex with the bicyclic AMPA analogue (S)-4-AHCP
Descriptor: 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, GLYCEROL, SULFATE ION, ...
Authors:Nielsen, B.B, Pickering, D.S, Greenwood, J.R, Brehm, L, Gajhede, M, Schousboe, A, Kastrup, J.S.
Deposit date:2004-12-15
Release date:2005-04-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP
FEBS J., 272, 2005
1YAE
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Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid
Descriptor: (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor, ...
Authors:Nanao, M.H, Green, T, Stern-Bach, Y, Heinemann, S.F, Choe, S.
Deposit date:2004-12-17
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid.
Proc.Natl.Acad.Sci.USA, 102, 2005
1YCJ
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BU of 1ycj by Molmil
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Descriptor: GLUTAMIC ACID, Ionotropic glutamate receptor 5, SULFATE ION
Authors:Naur, P, Vestergaard, B, Skov, L.K, Egebjerg, J, Gajhede, M, Kastrup, J.S.
Deposit date:2004-12-22
Release date:2005-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Febs Lett., 579, 2005
2A5S
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BU of 2a5s by Molmil
Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate
Descriptor: GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2A5T
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Crystal Structure Of The NR1/NR2A ligand-binding cores complex
Descriptor: GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ...
Authors:Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E.
Deposit date:2005-06-30
Release date:2005-11-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
2AIX
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X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (s)-thio-atpa at 2.2 a resolution.
Descriptor: (S)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOTHIAZOL-4-YL) PROPRIONIC ACID, Glutamate receptor 2
Authors:Kastrup, J.S.
Deposit date:2005-08-01
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Distinct kinetics of ionotropic glutamate receptor 2 splice variants characterized by fast agonist application and crystallization of a receptor-ligand complex.
To be Published
2AL5
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Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam
Descriptor: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
2AL4
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CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614.
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE, Glutamate receptor 2, ...
Authors:Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
2ANJ
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Crystal Structure of the Glur2 Ligand Binding Core (S1S2J-Y450W) Mutant in Complex With the Partial Agonist Kainic Acid at 2.1 A Resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2
Authors:Holm, M.M, Naur, P, Vestergaard, B, Geballe, M.T, Gajhede, M, Kastrup, J.S, Traynelis, S.F, Egebjerg, J.
Deposit date:2005-08-11
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2: a mutagenic, kinetic, and crystallographic study
J.Biol.Chem., 280, 2005
2F36
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Crystal Structure of the GluR5 Ligand Binding Core Dimer with Glutamate At 2.1 Angstroms Resolution
Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 1, GLUTAMIC ACID, ...
Authors:Mayer, M.L.
Deposit date:2005-11-18
Release date:2006-04-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
J.Neurosci., 26, 2006
2F34
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Crystal Structure of the GluR5 Ligand Binding Core Dimer with UBP310 At 1.74 Angstroms Resolution
Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, CHLORIDE ION, GLUTAMATE RECEPTOR, ...
Authors:Mayer, M.L.
Deposit date:2005-11-18
Release date:2006-04-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
J.Neurosci., 26, 2006
2F35
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Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution
Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE, CHLORIDE ION, GLUTAMATE RECEPTOR, ...
Authors:Mayer, M.L.
Deposit date:2005-11-18
Release date:2006-04-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
J.Neurosci., 26, 2006
2GFE
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Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
Authors:Mayer, M.L.
Deposit date:2006-03-21
Release date:2006-08-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate.
J.Neurosci., 26, 2006
2CMO
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The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209
Descriptor: 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ...
Authors:Kasper, C, Pickering, D.S, Mirza, O, Olsen, L, Kristensen, A.S, Greenwood, J.R, Liljefors, T, Schousboe, A, Watjen, F, Gajhede, M, Sigurskjold, B.W, Kastrup, J.S.
Deposit date:2006-05-11
Release date:2006-06-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Structure of a Mixed Glur2 Ligand-Binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-Ns1209.
J.Mol.Biol., 357, 2006
2I0B
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Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2, ...
Authors:Mayer, M.L.
Deposit date:2006-08-10
Release date:2006-11-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Conformational restriction blocks glutamate receptor desensitization.
Nat.Struct.Mol.Biol., 13, 2006
2I0C
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Crystal structure of the GluR6 ligand binding core dimer crosslinked by disulfide bonds between Y490C and L752C at 2.25 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2
Authors:Mayer, M.L.
Deposit date:2006-08-10
Release date:2006-11-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Conformational restriction blocks glutamate receptor desensitization.
Nat.Struct.Mol.Biol., 13, 2006

220113

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