5DKR
 
 | | Crystal Structure of Calcium-loaded S100B bound to SBi29 | | Descriptor: | 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-6-carboximidamide, CALCIUM ION, Protein S100-B | | Authors: | Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J. | | Deposit date: | 2015-09-03 | | Release date: | 2016-01-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.742 Å) | | Cite: | Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
J.Med.Chem., 59, 2016
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5AAN
 | | Crystal structure of Drosophila NCS-1 bound to penothiazine FD44 | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, CG5907-PA, ... | | Authors: | Chaves-Sanjuan, A, Infantes, L, Sanchez-Barrena, M.J. | | Deposit date: | 2015-07-27 | | Release date: | 2017-01-25 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5ER5
 | | Crystal Structure of Calcium-loaded S100B bound to SC1990 | | Descriptor: | CALCIUM ION, ETHIDIUM, Protein S100-B | | Authors: | Cavalier, M.C, Melville, Z.E, Aligholizadeh, E, Fang, L, Alasady, M.J, Pierce, A.D, Wilder, P.T, MacKerell Jr, A.D, Weber, D.J. | | Deposit date: | 2015-11-13 | | Release date: | 2016-06-08 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Novel protein-inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography.
Acta Crystallogr D Struct Biol, 72, 2016
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5G4P
 | | Crystal structure of human hippocalcin at 2.4 A resolution | | Descriptor: | CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin | | Authors: | Antonyuk, S.V, Helassa, N, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. | | Deposit date: | 2016-05-15 | | Release date: | 2017-05-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.
Hum. Mol. Genet., 26, 2017
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5G58
 | | Crystal structure of A190T mutant of human hippocalcin AT 2.5 A resolution | | Descriptor: | CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin | | Authors: | Antonyuk, S.V, Helassa, N, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. | | Deposit date: | 2016-05-22 | | Release date: | 2017-05-03 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.
Hum. Mol. Genet., 26, 2017
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5DKQ
 | | Crystal Structure of Calcium-loaded S100B bound to SBi4214 | | Descriptor: | 2,2'-[pentane-1,5-diylbis(oxybenzene-4,1-diyl)]di-1,4,5,6-tetrahydropyrimidine, CALCIUM ION, Protein S100-B | | Authors: | Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J. | | Deposit date: | 2015-09-03 | | Release date: | 2016-01-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.591 Å) | | Cite: | Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
J.Med.Chem., 59, 2016
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5CSN
 | | S100B-RSK1 crystal structure C | | Descriptor: | CALCIUM ION, Protein S100-B, Ribosomal protein S6 kinase alpha-1 | | Authors: | Gogl, G, Nyitray, L. | | Deposit date: | 2015-07-23 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
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5CSJ
 | | S100B-RSK1 crystal structure B | | Descriptor: | CALCIUM ION, CHLORIDE ION, Protein S100-B, ... | | Authors: | Gogl, G, Nyitray, L. | | Deposit date: | 2015-07-23 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
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5CSI
 | | S100B-RSK1 crystal structure A' | | Descriptor: | CALCIUM ION, Protein S100-B, Ribosomal protein S6 kinase alpha-1 | | Authors: | Gogl, G, Nyitray, L. | | Deposit date: | 2015-07-23 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
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5D7F
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5CSF
 | | S100B-RSK1 crystal structure A | | Descriptor: | CALCIUM ION, Protein S100-B, Ribosomal protein S6 kinase alpha-1 | | Authors: | Gogl, G, Nyitray, L. | | Deposit date: | 2015-07-23 | | Release date: | 2015-11-11 | | Last modified: | 2016-01-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
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1QX2
 | | X-ray Structure of Calcium-loaded Calbindomodulin (A Calbindin D9k Re-engineered to Undergo a Conformational Opening) at 1.44 A Resolution | | Descriptor: | CALCIUM ION, Vitamin D-dependent calcium-binding protein, intestinal, ... | | Authors: | Bunick, C.G, Nelson, M.R, Mangahas, S, Mizoue, L.S, Bunick, G.J, Chazin, W.J. | | Deposit date: | 2003-09-04 | | Release date: | 2004-05-25 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Designing Sequence to Control Protein Function in an EF-Hand Protein
J.Am.Chem.Soc., 126, 2004
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1MWN
 | | Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12 | | Descriptor: | CALCIUM ION, F-actin capping protein alpha-1 subunit, S-100 protein, ... | | Authors: | Inman, K.G, Yang, R, Rustandi, R.R, Miller, K.E, Baldisseri, D.M, Weber, D.J. | | Deposit date: | 2002-09-30 | | Release date: | 2002-12-18 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12
J.Mol.Biol., 324, 2002
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1QLS
 | | S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS | | Descriptor: | ANNEXIN I, CALCIUM ION, S100C PROTEIN | | Authors: | Rety, S, Sopkova, J, Renouard, M, Osterloh, D, Gerke, V, Russo-Marie, F, Lewit-Bentley, A. | | Deposit date: | 1999-09-15 | | Release date: | 2000-02-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis of the Ca2+ Dependent Association between S100C (S100A11) and its Target, the N-Terminal Part of Annexin I
Structure, 8, 2000
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1IGV
 | | BOVINE CALBINDIN D9K BINDING MN2+ | | Descriptor: | MANGANESE (II) ION, VITAMIN D-DEPENDENT CALCIUM-BINDING PROTEIN, INTESTINAL | | Authors: | Andersson, E.M. | | Deposit date: | 2001-04-18 | | Release date: | 2001-04-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis for the negative allostery between Ca(2+)- and Mg(2+)-binding in the intracellular Ca(2+)-receptor calbindin D9k.
Protein Sci., 6, 1997
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1NCZ
 | | TROPONIN C | | Descriptor: | SULFATE ION, TERBIUM(III) ION, TROPONIN C | | Authors: | Sundaralingam, M, Rao, S.T. | | Deposit date: | 1996-06-02 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray structures of Mn, Cd and Tb metal complexes of troponin C.
Acta Crystallogr.,Sect.D, 52, 1996
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1NCY
 | | TROPONIN-C, COMPLEX WITH MANGANESE | | Descriptor: | MANGANESE (II) ION, SULFATE ION, TROPONIN C | | Authors: | Sundaralingam, M, Rao, S.T. | | Deposit date: | 1996-06-02 | | Release date: | 1997-01-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | X-ray structures of Mn, Cd and Tb metal complexes of troponin C.
Acta Crystallogr.,Sect.D, 52, 1996
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1NCX
 | | TROPONIN C | | Descriptor: | CADMIUM ION, SULFATE ION, TROPONIN C | | Authors: | Sundaralingam, M, Rao, S.T. | | Deposit date: | 1996-06-02 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray structures of Mn, Cd and Tb metal complexes of troponin C.
Acta Crystallogr.,Sect.D, 52, 1996
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1IG5
 | | BOVINE CALBINDIN D9K BINDING MG2+ | | Descriptor: | MAGNESIUM ION, VITAMIN D-DEPENDENT CALCIUM-BINDING PROTEIN, INTESTINAL | | Authors: | Andersson, E.M, Svensson, L.A. | | Deposit date: | 2001-04-17 | | Release date: | 2001-04-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis for the negative allostery between Ca(2+)- and Mg(2+)-binding in the intracellular Ca(2+)-receptor calbindin D9k.
Protein Sci., 6, 1997
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1N65
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1MHO
 | | THE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN | | Descriptor: | CALCIUM ION, S-100 PROTEIN | | Authors: | Matsumura, H, Shiba, T, Inoue, T, Harada, S, Yasushi, K.A.I. | | Deposit date: | 1997-09-11 | | Release date: | 1998-11-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A novel mode of target recognition suggested by the 2.0 A structure of holo S100B from bovine brain.
Structure, 6, 1998
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1HT9
 | | DOMAIN SWAPPING EF-HANDS | | Descriptor: | CALBINDIN D9K, CALCIUM ION | | Authors: | Hakansson, M, Svensson, A.L, Fast, J, Linse, S. | | Deposit date: | 2000-12-29 | | Release date: | 2001-05-09 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | An extended hydrophobic core induces EF-hand swapping.
Protein Sci., 10, 2001
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1HQV
 | | STRUCTURE OF APOPTOSIS-LINKED PROTEIN ALG-2 | | Descriptor: | CALCIUM ION, PROGRAMMED CELL DEATH PROTEIN 6 | | Authors: | Jia, J, Tarabykina, S, Hansen, C, Berchtold, M, Cygler, M. | | Deposit date: | 2000-12-19 | | Release date: | 2001-05-02 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of apoptosis-linked protein ALG-2: insights into Ca2+-induced changes in penta-EF-hand proteins.
Structure, 9, 2001
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1MQ1
 | | Ca2+-S100B-TRTK-12 complex | | Descriptor: | F-actin capping protein alpha-1 subunit, S-100 protein, beta chain | | Authors: | McClintock, K.A, Shaw, G.S. | | Deposit date: | 2002-09-13 | | Release date: | 2002-12-25 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex.
J.Biol.Chem., 278, 2003
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1TNX
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