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2DLZ
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Solution structure of the SH2 domain of human protein vav-2
Descriptor: Protein vav-2
Authors:Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-20
Release date:2007-04-03
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the SH2 domain of human protein vav-2
To be Published
2DLY
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BU of 2dly by Molmil
Solution structure of the SH2 domain of murine Fyn-related kinase
Descriptor: Fyn-related kinase
Authors:Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-20
Release date:2006-10-20
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the SH2 domain of murine Fyn-related kinase
To be Published
2GSB
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Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1
Descriptor: Ras GTPase-activating protein 1
Authors:Kurosaki, C, Suetake, T, Yoshida, M, Hayashi, F, Yokoyma, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-26
Release date:2007-05-01
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1
To be Published
2H46
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Native domain-swapped dimer crystal structure of the Grb2 SH2 domain
Descriptor: GLYCEROL, Growth Receptor Binding Protein 2
Authors:Benfield, A.P, Martin, S.F, Whiddon, B.B.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2H5K
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Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2
Descriptor: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand
Authors:Benfield, A.P, Whiddon, B.B, Martin, S.F.
Deposit date:2006-05-26
Release date:2006-08-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2IUH
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide
Descriptor: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
Authors:Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2021-04-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUG
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
Authors:Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUI
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide
Descriptor: Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta
Authors:Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
Deposit date:2006-06-03
Release date:2006-06-06
Last modified:2021-04-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2H8H
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Src kinase in complex with a quinazoline inhibitor
Descriptor: N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE, Proto-oncogene tyrosine-protein kinase Src
Authors:Otterbein, L.R, Norman, R, Pauptit, R.A, Rowsell, S, Breed, J.
Deposit date:2006-06-07
Release date:2006-11-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
J.Med.Chem., 49, 2006
2HDV
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Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B
Descriptor: SH2-B PH domain containing signaling mediator 1 gamma isoform
Authors:Hu, J, Hubbard, S.R.
Deposit date:2006-06-20
Release date:2006-08-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2HDX
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Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
Descriptor: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform
Authors:Hu, J, Hubbard, S.R.
Deposit date:2006-06-21
Release date:2006-08-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2HMH
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Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.
Descriptor: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3
Authors:Bergamin, E, Wu, J, Hubbard, S.R.
Deposit date:2006-07-11
Release date:2006-08-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.
Structure, 14, 2006
2IZV
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CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ...
Authors:Debreczeni, J.E, Bullock, A, Papagrigoriou, E, Turnbull, A, Pike, A.C.W, Gorrec, F, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Knapp, S.
Deposit date:2006-07-26
Release date:2006-08-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Structure, 15, 2007
2HUW
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X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
Descriptor: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION
Authors:Benfield, A.P, Martin, S.F.
Deposit date:2006-07-27
Release date:2006-08-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 45, 2006
2DVJ
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phosphorylated Crk-II
Descriptor: V-crk sarcoma virus CT10 oncogene homolog, isoform a
Authors:Kobashigawa, Y, Inagaki, F.
Deposit date:2006-07-31
Release date:2007-05-08
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
Nat.Struct.Mol.Biol., 14, 2007
2DX0
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Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2
Descriptor: Phospholipase C, gamma 2, SULFATE ION
Authors:Handa, N, Takagi, T, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-22
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2
To be Published
2OQ1
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Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide
Descriptor: LEAD (II) ION, T-cell surface glycoprotein CD3 zeta chain, Tyrosine-protein kinase ZAP-70
Authors:Hatada, M.H, Laird, E.R, Green, J, Morgenstern, J, Ram, M.K.
Deposit date:2007-01-30
Release date:2007-03-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for the interaction of ZAP-70 with the T-cell receptor
Nature, 377, 1995
2ECD
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Solution structure of the human ABL2 SH2 domain
Descriptor: Tyrosine-protein kinase ABL2
Authors:Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-02-13
Release date:2008-02-19
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the human ABL2 SH2 domain
To be Published
2OZO
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Autoinhibited intact human ZAP-70
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase ZAP-70
Authors:Deindl, S, Kadlecek, T.A, Brdicka, T, Cao, X, Weiss, A, Kuriyan, J.
Deposit date:2007-02-26
Release date:2007-05-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70.
Cell(Cambridge,Mass.), 129, 2007
2EKX
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Solution structure of the human BMX SH2 domain
Descriptor: Cytoplasmic tyrosine-protein kinase BMX
Authors:Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-26
Release date:2007-10-02
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the human BMX SH2 domain
To be Published
2EO3
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Solution structure of the SH2 domain from human Crk-like protein
Descriptor: Crk-like protein
Authors:Kurosaki, C, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-28
Release date:2008-04-08
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the SH2 domain from human Crk-like protein
To be Published
2EOB
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Solution structure of the second SH2 domain from rat PLC gamma-2
Descriptor: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2
Authors:Sano, R, Hayashi, F, Nagashima, T, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-29
Release date:2008-04-01
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the second SH2 domain from rat PLC gamma-2
To be Published
2EO6
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Solution structure of the SH2 domain from mouse B-cell linker protein BLNK
Descriptor: B-cell linker protein
Authors:Sano, R, Hayashi, F, Kurosaki, C, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-29
Release date:2008-04-01
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of the SH2 domain from mouse B-cell linker protein BLNK
To be Published
2YSX
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Solution structure of the human SHIP SH2 domain
Descriptor: Signaling inositol polyphosphate phosphatase SHIP II
Authors:Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-04
Release date:2008-04-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the human SHIP SH2 domain
To be Published
2YU7
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Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
Descriptor: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A
Authors:Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-05
Release date:2008-04-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
To be Published

220113

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