9K75
 
 | | SARS-CoV-2 related bat coronavirus BANAL-103 spike in the closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Qingqing, L, Xiao, C, Xiaoning, L, Yibing, Z, Ru, L, Zirui, K, Didi, W, Jiaxu, W, Lili, L, Junxia, Y, Jianxiang, S, Shuiling, J, Ying, P, Na, Z, Yushun, W, Jian, S. | | Deposit date: | 2024-10-23 | | Release date: | 2025-07-16 | | Last modified: | 2026-02-04 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses.
J.Virol., 99, 2025
|
|
8ZY2
 | | Sarbecovirus BANAL-20-52 Spike Trimer in a Locked Conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | | Authors: | Wang, J, Xiong, X. | | Deposit date: | 2024-06-16 | | Release date: | 2025-02-05 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | SARS-related coronavirus S-protein structures reveal synergistic RBM interactions underpinning high-affinity human ACE2 binding.
Sci Adv, 11, 2025
|
|
8ZY3
 | | Sarbecovirus BANAL-20-236 Spike Trimer in a Locked Conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Wang, J, Xiong, X. | | Deposit date: | 2024-06-16 | | Release date: | 2025-02-05 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | SARS-related coronavirus S-protein structures reveal synergistic RBM interactions underpinning high-affinity human ACE2 binding.
Sci Adv, 11, 2025
|
|
7T5O
 | | VFLIP Spike Trimer with GAR03 | | Descriptor: | GAR03 Fab heavy chain, GAR03 Fab light chain, Spike glycoprotein | | Authors: | Sobti, M, Stewart, A.G, Rouet, R, Langley, D.B. | | Deposit date: | 2021-12-12 | | Release date: | 2023-01-25 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients.
Nat Commun, 14, 2023
|
|
7SL5
 | |
7SKZ
 | |
7TGE
 | |
11HK
 | |
36AZ
 | | Structure of BA.1-S-RBD/2130WT/2196-S93Y | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2130WT heavy chain, 2130WT light chain, ... | | Authors: | Du, J, Pallesen, J. | | Deposit date: | 2026-05-28 | | Release date: | 2026-07-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure-Guided Design of Therapeutic Antibodies Targeting SARS-CoV-2 Omicron Variants.
Res Sq, 2026
|
|
11HW
 | |
22OV
 | | SARS-CoV-2 BA.3.2.2(RE.2.2) spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | Authors: | Li, L.J, Qu, H, Wu, Q.L, Gao, G.F. | | Deposit date: | 2026-01-19 | | Release date: | 2026-08-05 | | Method: | ELECTRON MICROSCOPY (2.37 Å) | | Cite: | Receptor Binding, Immune Escape, and Cross-Species Transmission of SARS-CoV-2 Serum-Defined Lineage 7, BA.3.2.2(RE.2.2)
To Be Published
|
|
22HP
 | | SARS-CoV-2 BA.3.2.2(RE.2.2) RBD in complex with monoclonal antibodies S2K146 and L4.65 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, The heavy chain of monoclonal antibody L4.65, ... | | Authors: | Li, L.J, Qu, H, Wu, Q.L, Gao, G.F. | | Deposit date: | 2026-01-11 | | Release date: | 2026-08-05 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Receptor Binding, Immune Escape, and Cross-Species Transmission of SARS-CoV-2 Serum-Defined Lineage 7, BA.3.2.2(RE.2.2)
To Be Published
|
|
27KE
 | |
27KF
 | |
6M1V
 | |
6LXT
 | | Structure of post fusion core of 2019-nCoV S2 subunit | | Descriptor: | Spike protein S2, TETRAETHYLENE GLYCOL, ZINC ION | | Authors: | Zhu, Y, Sun, F. | | Deposit date: | 2020-02-11 | | Release date: | 2020-02-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.
Cell Res., 30, 2020
|
|
6LVN
 | | Structure of the 2019-nCoV HR2 Domain | | Descriptor: | Spike protein S2' | | Authors: | Zhu, Y, Sun, F. | | Deposit date: | 2020-02-04 | | Release date: | 2020-02-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Crystal structure of HR2 domain of 2019-nCoV S2 subunit
To Be Published
|
|
7MKL
 | |
7MJI
 | | Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 (focused refinement of RBD and VH ab8) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VH ab8 | | Authors: | Zhu, X, Mannar, D, Srivastava, S.S, Berezuk, A.M, Demers, J.P, Saville, J.W, Leopold, K, Li, W, Dimitrov, D.S, Tuttle, K.S, Zhou, S, Chittori, S, Subramaniam, S. | | Deposit date: | 2021-04-20 | | Release date: | 2021-05-12 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.
Plos Biol., 19, 2021
|
|
7MKM
 | |
7MJH
 | | Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | Authors: | Zhu, X, Mannar, D, Srivastava, S.S, Berezuk, A.M, Demers, J.P, Saville, J.W, Leopold, K, Li, W, Dimitrov, D.S, Tuttle, K.S, Zhou, S, Chittori, S, Subramaniam, S. | | Deposit date: | 2021-04-20 | | Release date: | 2021-05-12 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.
Plos Biol., 19, 2021
|
|
7MJG
 | | Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Zhu, X, Mannar, D, Srivastava, S.S, Berezuk, A.M, Demers, J.P, Saville, J.W, Leopold, K, Li, W, Dimitrov, D.S, Tuttle, K.S, Zhou, S, Chittori, S, Subramaniam, S. | | Deposit date: | 2021-04-20 | | Release date: | 2021-05-12 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.
Plos Biol., 19, 2021
|
|
7MF1
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 47D1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 47D1 Fab heavy chain, ... | | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | | Deposit date: | 2021-04-08 | | Release date: | 2021-05-12 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.092 Å) | | Cite: | Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2.
Cell Rep, 35, 2021
|
|
7MMO
 | | LY-CoV1404 neutralizing antibody against SARS-CoV-2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LY-CoV1404 Fab heavy chain, LY-CoV1404 Fab light chain, ... | | Authors: | Hendle, J, Pustilnik, A, Sauder, J.M, Coleman, K.A, Boyles, J.S, Dickinson, C.D. | | Deposit date: | 2021-04-30 | | Release date: | 2021-05-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.427 Å) | | Cite: | LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.
Biorxiv, 2022
|
|
9YYU
 | |
