9K75
 
 | | SARS-CoV-2 related bat coronavirus BANAL-103 spike in the closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Qingqing, L, Xiao, C, Xiaoning, L, Yibing, Z, Ru, L, Zirui, K, Didi, W, Jiaxu, W, Lili, L, Junxia, Y, Jianxiang, S, Shuiling, J, Ying, P, Na, Z, Yushun, W, Jian, S. | | Deposit date: | 2024-10-23 | | Release date: | 2025-07-16 | | Last modified: | 2026-02-04 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses.
J.Virol., 99, 2025
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7SL5
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7SKZ
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7TGE
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7T5O
 | | VFLIP Spike Trimer with GAR03 | | Descriptor: | GAR03 Fab heavy chain, GAR03 Fab light chain, Spike glycoprotein | | Authors: | Sobti, M, Stewart, A.G, Rouet, R, Langley, D.B. | | Deposit date: | 2021-12-12 | | Release date: | 2023-01-25 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients.
Nat Commun, 14, 2023
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8ZY3
 | | Sarbecovirus BANAL-20-236 Spike Trimer in a Locked Conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Wang, J, Xiong, X. | | Deposit date: | 2024-06-16 | | Release date: | 2025-02-05 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | SARS-related coronavirus S-protein structures reveal synergistic RBM interactions underpinning high-affinity human ACE2 binding.
Sci Adv, 11, 2025
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8ZY2
 | | Sarbecovirus BANAL-20-52 Spike Trimer in a Locked Conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | | Authors: | Wang, J, Xiong, X. | | Deposit date: | 2024-06-16 | | Release date: | 2025-02-05 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | SARS-related coronavirus S-protein structures reveal synergistic RBM interactions underpinning high-affinity human ACE2 binding.
Sci Adv, 11, 2025
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7LQ7
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COVA1-16 heavy chain, COVA1-16 light chain, ... | | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | | Deposit date: | 2021-02-13 | | Release date: | 2021-09-15 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.
Sci Transl Med, 13, 2021
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8R87
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6YLA
 | | Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | Authors: | Huo, J, Zhao, Y, Ren, J, Zhou, D, Ginn, H.M, Fry, E.E, Owens, R, Stuart, D.I. | | Deposit date: | 2020-04-06 | | Release date: | 2020-04-15 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Cell Host Microbe, 28, 2020
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6YZ5
 | | H11-D4 complex with SARS-CoV-2 RBD | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Naismith, J.H, Huo, J, Mikolajek, H, Ward, P, Dumoux, M, Owens, R.J, Le Bas, A. | | Deposit date: | 2020-05-06 | | Release date: | 2020-06-03 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | H11-D4 complex with SARS-CoV-2 RBD
To Be Published
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9IQP
 | | Crystal structure of the Wuhan SARS-CoV-2 Spike RBD (319-541) complexed with 1p1B10 nanobody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody 1p1B10, SODIUM ION, ... | | Authors: | Sluchanko, N.N, Matyuta, I.O, Dronova, E.A, Favorskaya, I.A, Esmagambetov, I.B, Shcheblyakov, D.V, Logunov, D.Y, Gintsburg, A.L, Popov, V.O, Boyko, K.M. | | Deposit date: | 2024-07-13 | | Release date: | 2025-07-16 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Ultra-potent RBM-specific single-domain antibody broadly neutralizes multiple SARS-CoV-2 variants with picomolar activity.
Int.J.Biol.Macromol., 319, 2025
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9JEB
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9JS4
 | | Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD | | Descriptor: | Heavy chain of 8G3, Light chain of 8G3, Spike glycoprotein | | Authors: | Li, J, Li, H. | | Deposit date: | 2024-09-30 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering.
Proc.Natl.Acad.Sci.USA, 122, 2025
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6VYB
 | | SARS-CoV-2 spike ectodomain structure (open state) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Walls, A.C, Park, Y.J, Tortorici, M.A, Wall, A, Seattle Structural Genomics Center for Infectious Disease (SSGCID), McGuire, A.T, Veesler, D. | | Deposit date: | 2020-02-25 | | Release date: | 2020-03-11 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Cell, 181, 2020
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6W41
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab heavy chain, CR3022 Fab light chain, ... | | Authors: | Yuan, M, Wu, N.C, Zhu, X.Y, Wilson, I.A. | | Deposit date: | 2020-03-09 | | Release date: | 2020-03-25 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.084 Å) | | Cite: | A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV.
Science, 368, 2020
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9D8H
 | | JN.1 SARS-COV-2 Spike 3-down conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Windsor, I.W, Wu, H. | | Deposit date: | 2024-08-19 | | Release date: | 2025-10-29 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | SARS-CoV-2 JN.1 and KP.2 spike characteristics and neutralization of JN.1-derived sublineages and T cell responses from mice immunized with monovalent JN.1- and KP.2-adapted BNT162b2 COVID-19 vaccines
To Be Published
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9D8K
 | | KP.2 SARS-COV-2 Spike 1-up conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Windsor, I.W, Wu, H. | | Deposit date: | 2024-08-19 | | Release date: | 2025-10-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | SARS-CoV-2 JN.1 and KP.2 spike characteristics and neutralization of JN.1-derived sublineages and T cell responses from mice immunized with monovalent JN.1- and KP.2-adapted BNT162b2 COVID-19 vaccines
To Be Published
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9D8I
 | | JN.1 SARS-COV-2 Spike 1-up conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Windsor, I.W, Wu, H. | | Deposit date: | 2024-08-19 | | Release date: | 2025-10-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | SARS-CoV-2 JN.1 and KP.2 spike characteristics and neutralization of JN.1-derived sublineages and T cell responses from mice immunized with monovalent JN.1- and KP.2-adapted BNT162b2 COVID-19 vaccines
To Be Published
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9D8L
 | | KP.2 SARS-COV-2 Spike 2-up conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Windsor, I.W, Wu, H. | | Deposit date: | 2024-08-19 | | Release date: | 2025-10-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | SARS-CoV-2 JN.1 and KP.2 spike characteristics and neutralization of JN.1-derived sublineages and T cell responses from mice immunized with monovalent JN.1- and KP.2-adapted BNT162b2 COVID-19 vaccines
To Be Published
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9IB1
 | | Cryo-EM focus map of prefusion SARS-CoV-2 spike (RBDs: 1 up & 2 down) bound to RBD-targeting MO176-117 antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody MO176-117, Light chain of antibody MO176-117, ... | | Authors: | Schulte, T, Wallden, W, Andrell, J, Ohlin, M. | | Deposit date: | 2025-02-11 | | Release date: | 2026-03-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A stochastic codon deletion generates a SARS-CoV-2-neutralizing antibody
To Be Published
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9IB0
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9IB2
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9LVS
 | | Cryo-EM structure of the SARS-CoV-2 spike protein in complex with S416 | | Descriptor: | 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fang, Y, Binghao, Z. | | Deposit date: | 2025-02-12 | | Release date: | 2026-03-04 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Cryo-EM structure of the SARS-CoV-2 spike protein(one RBD up state)
To Be Published
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9IB3
 | | Cryo-EM focus map of prefusion SARS-CoV-2 spike (RBDs: 2 up & 1 down) bound to RBD-targeting MO176-117 antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody MO176-117, Light chain of antibody MO176-117, ... | | Authors: | Schulte, T, Wallden, W, Andrell, J, Ohlin, M. | | Deposit date: | 2025-02-11 | | Release date: | 2026-03-04 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | A stochastic codon deletion generates a SARS-CoV-2-neutralizing antibody
To Be Published
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