9K75
 
 | | SARS-CoV-2 related bat coronavirus BANAL-103 spike in the closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Qingqing, L, Xiao, C, Xiaoning, L, Yibing, Z, Ru, L, Zirui, K, Didi, W, Jiaxu, W, Lili, L, Junxia, Y, Jianxiang, S, Shuiling, J, Ying, P, Na, Z, Yushun, W, Jian, S. | | Deposit date: | 2024-10-23 | | Release date: | 2025-07-16 | | Last modified: | 2026-02-04 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses. J.Virol., 99, 2025
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8ZY2
 
 | | Sarbecovirus BANAL-20-52 Spike Trimer in a Locked Conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | | Authors: | Wang, J, Xiong, X. | | Deposit date: | 2024-06-16 | | Release date: | 2025-02-05 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | SARS-related coronavirus S-protein structures reveal synergistic RBM interactions underpinning high-affinity human ACE2 binding. Sci Adv, 11, 2025
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8ZY3
 
 | | Sarbecovirus BANAL-20-236 Spike Trimer in a Locked Conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Wang, J, Xiong, X. | | Deposit date: | 2024-06-16 | | Release date: | 2025-02-05 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | SARS-related coronavirus S-protein structures reveal synergistic RBM interactions underpinning high-affinity human ACE2 binding. Sci Adv, 11, 2025
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7SL5
 
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7SKZ
 
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7T5O
 
 | | VFLIP Spike Trimer with GAR03 | | Descriptor: | GAR03 Fab heavy chain, GAR03 Fab light chain, Spike glycoprotein | | Authors: | Sobti, M, Stewart, A.G, Rouet, R, Langley, D.B. | | Deposit date: | 2021-12-12 | | Release date: | 2023-01-25 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients. Nat Commun, 14, 2023
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7TGE
 
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36AZ
 
 | | Structure of BA.1-S-RBD/2130WT/2196-S93Y | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2130WT heavy chain, 2130WT light chain, ... | | Authors: | Du, J, Pallesen, J. | | Deposit date: | 2026-05-28 | | Release date: | 2026-07-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure-Guided Design of Therapeutic Antibodies Targeting SARS-CoV-2 Omicron Variants. Res Sq, 2026
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27KE
 
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27KF
 
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9ZT7
 
 | | SARS-CoV-2 S2 in complex with COV2-2509 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COV2-2509 Fab-Heavy chain, ... | | Authors: | Park, S, Ward, A.B. | | Deposit date: | 2025-12-23 | | Release date: | 2026-03-11 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | The buried S2 apex of SARS-CoV-2 spike elicits an immunodominant germline-restricted public antibody response. Biorxiv, 2026
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9Z12
 
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9ZT6
 
 | | SARS-CoV-2 S2 in complex with polyclonal Fab-B_Donor8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | | Authors: | Park, S, Ward, A.B. | | Deposit date: | 2025-12-23 | | Release date: | 2026-03-11 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | The buried S2 apex of SARS-CoV-2 spike elicits an immunodominant germline-restricted public antibody response. Biorxiv, 2026
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9Z18
 
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9ZT8
 
 | | Stabilized SARS-CoV-2 S2 apo | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2 | | Authors: | Park, S, Ward, A.B. | | Deposit date: | 2025-12-23 | | Release date: | 2026-03-11 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | The buried S2 apex of SARS-CoV-2 spike elicits an immunodominant germline-restricted public antibody response. Biorxiv, 2026
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9YJI
 
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9ZT5
 
 | | SARS-CoV-2 S2 in complex with polyclonal Fab-B_Donor3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | | Authors: | Park, S, Ward, A.B. | | Deposit date: | 2025-12-23 | | Release date: | 2026-03-11 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | The buried S2 apex of SARS-CoV-2 spike elicits an immunodominant germline-restricted public antibody response. Biorxiv, 2026
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7A29
 
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7A4N
 
 | | Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(S-closed trimer) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin | | Authors: | Rutten, L, Renault, L.L.R, Juraszek, J, Langedijk, J.P.M. | | Deposit date: | 2020-08-20 | | Release date: | 2020-11-04 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Stabilizing the closed SARS-CoV-2 spike trimer. Nat Commun, 12, 2021
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7A5R
 
 | | Complex of SARS-CoV-2 spike and CR3022 Fab (Non-Uniform Refinement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, ... | | Authors: | Wrobel, A.G, Benton, D.J, Rosenthal, P.B, Gamblin, S.J. | | Deposit date: | 2020-08-21 | | Release date: | 2020-09-16 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein. Nat Commun, 11, 2020
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7A5S
 
 | | Complex of SARS-CoV-2 spike and CR3022 Fab (Homogeneous Refinement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, ... | | Authors: | Wrobel, A.G, Benton, D.J, Rosenthal, P.B, Gamblin, S.J. | | Deposit date: | 2020-08-21 | | Release date: | 2020-09-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein. Nat Commun, 11, 2020
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7A25
 
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7A93
 
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9FCM
 
 | | Single-domain antibody binding the SARS-COV2 S2 | | Descriptor: | CHLORIDE ION, Single-domain antibody R3DC23, Spike protein S2' | | Authors: | Vann Molle, I, Remaut, H. | | Deposit date: | 2024-05-15 | | Release date: | 2025-05-21 | | Last modified: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base. Nat Commun, 16, 2025
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9FGR
 
 | | SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, scFv76-77 single chain fragment | | Authors: | Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M. | | Deposit date: | 2024-05-25 | | Release date: | 2024-06-05 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of scFv76-77 in complex with SARS-CoV-2 Spike protein To Be Published
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