PDB: 107 件ウェブページステータス検索Chemie searchBIRD

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5VI6	Crystal structure of histone deacetylase 8 in complex with trapoxin A 分子名称: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Histone deacetylase 8, ... 著者 Porter, N.J, Christianson, D.W. 登録日 2017-04-14 公開日 2017-09-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.237 Å) 主引用文献 Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8. ACS Chem. Biol., 12, 2017
1W22	Crystal structure of inhibited human HDAC8 分子名称: HISTONE DEACETYLASE 8, N-HYDROXY-4-(METHYL{[5-(2-PYRIDINYL)-2-THIENYL]SULFONYL}AMINO)BENZAMIDE, POTASSIUM ION, ... 著者 Vannini, A, Volpari, C, Caroli Casavola, E, Di Marco, S. 登録日 2004-06-25 公開日 2004-09-24 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor Proc.Natl.Acad.Sci.USA, 101, 2004
4BZ8	Crystal structure of Schistosoma mansoni HDAC8 complexed with J1038 分子名称: (2R)-2-methyl-3-oxo-4H-1,4-benzothiazine-6-carbohydroxamic acid, HISTONE DEACETYLASE 8, POTASSIUM ION, ... 著者 Marek, M, Romier, C. 登録日 2013-07-24 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni. Plos Pathog., 9, 2013
4BZ9	Crystal structure of Schistosoma mansoni HDAC8 complexed with J1075 分子名称: 3-chlorobenzothiophene-2-carbohydroxamic acid, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Marek, M, Romier, C. 登録日 2013-07-24 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni. Plos Pathog., 9, 2013
4BZ6	Crystal structure of Schistosoma mansoni HDAC8 complexed with SAHA 分子名称: DIMETHYLFORMAMIDE, GLYCEROL, HISTONE DEACETYLASE 8, ... 著者 Marek, M, Romier, C. 登録日 2013-07-24 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni. Plos Pathog., 9, 2013
4BZ5	Crystal structure of Schistosoma mansoni HDAC8 分子名称: HISTONE DEACETYLASE 8, L(+)-TARTARIC ACID, POTASSIUM ION, ... 著者 Marek, M, Romier, C. 登録日 2013-07-24 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.785 Å) 主引用文献 Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni. Plos Pathog., 9, 2013
4BZ7	Crystal structure of Schistosoma mansoni HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, HISTONE DEACETYLASE 8, ... 著者 Marek, M, Romier, C. 登録日 2013-07-24 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni. Plos Pathog., 9, 2013
6HSG	Crystal structure of Schistosoma mansoni HDAC8 H292M mutant complexed with NCC-149 分子名称: DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-01 公開日 2018-10-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.846 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HU1	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 10 分子名称: 4-chloranyl-3-[(2,4-dichlorophenyl)carbonylamino]-~{N}-oxidanyl-benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-05 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HU0	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 9 分子名称: 3-[(2,4-dichlorophenyl)carbonylamino]-4-methoxy-~{N}-oxidanyl-benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-05 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.746 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HQY	Crystal structure of Schistosoma mansoni HDAC8 complexed with PCI-34051 分子名称: 1-[(4-methoxyphenyl)methyl]-~{N}-oxidanyl-indole-6-carboxamide, GLYCEROL, Histone deacetylase, ... 著者 Marek, M, Shaik, T.B, Romier, C. 登録日 2018-09-25 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HTG	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 4 分子名称: 3-benzamido-4-chloranyl-~{N}-oxidanyl-benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-04 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.939 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HTZ	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 8 分子名称: 4-methoxy-~{N}-oxidanyl-3-(2-phenylethanoylamino)benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-05 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.841 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HRQ	Crystal structure of Schistosoma mansoni HDAC8 complexed with NCC-149 分子名称: DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-09-28 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.845 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HTI	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 6 分子名称: GLYCEROL, Histone deacetylase, POTASSIUM ION, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-04 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.693 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HTT	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 7 分子名称: DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-04 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.748 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HSZ	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 2 分子名称: 3-benzamido-4-methyl-~{N}-oxidanyl-benzamide, GLYCEROL, Histone deacetylase, ... 著者 Marek, M, Shaik, T.B, Romier, C. 登録日 2018-10-02 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.374 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HSF	Crystal structure of Schistosoma mansoni HDAC8 mutant H292M complexed with PCI-34051 分子名称: 1-[(4-methoxyphenyl)methyl]-~{N}-oxidanyl-indole-6-carboxamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-01 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.899 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HTH	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 5 分子名称: 4-methoxy-~{N}-oxidanyl-3-[(4-phenylphenyl)carbonylamino]benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-04 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HU3	Crystal structure of Schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor 分子名称: 1-[5-chloranyl-2-(4-fluoranylphenoxy)phenyl]-~{N}-oxidanyl-1,2,3-triazole-4-carboxamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-05 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.655 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HSH	Crystal structure of Schistosoma mansoni HDAC8 complexed with Quisinostat 分子名称: 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-01 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.545 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HT8	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 3 分子名称: 3-benzamido-4-methoxy-~{N}-oxidanyl-benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Marek, M, Shaik, T.B, Romier, C. 登録日 2018-10-03 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.497 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
6HU2	Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 11 分子名称: 4-methyl-~{N}-oxidanyl-3-[(phenylmethyl)amino]benzamide, DIMETHYLFORMAMIDE, GLYCEROL, ... 著者 Shaik, T.B, Marek, M, Romier, C. 登録日 2018-10-05 公開日 2018-10-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.986 Å) 主引用文献 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
3MZ6	Crystal structure of D101L Fe2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, FE (II) ION, Histone deacetylase 8, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
3MZ7	Crystal structure of D101L Co2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, COBALT (II) ION, GLYCEROL, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010

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