5VI6

Crystal structure of histone deacetylase 8 in complex with trapoxin A

Summary for 5VI6

• Entry DOI: 10.2210/pdb5vi6/pdb
• Related PRD ID: PRD_002282
• Descriptor: Histone deacetylase 8, Trapoxin A, ZINC ION, ... (7 entities in total)
• Functional Keywords: hdac, epigenetics, natural product inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 42741.02

Authors

Porter, N.J.,Christianson, D.W. (deposition date: 2017-04-14, release date: 2017-09-06, Last modification date: 2023-11-15)

• Primary citation: Porter, N.J.,Christianson, D.W.; Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8.; ACS Chem. Biol., 12:2281-2286, 2017; PubMed: 28846375; DOI: 10.1021/acschembio.7b00330

Experimental method

X-RAY DIFFRACTION (1.237 Å)