5VI6
Crystal structure of histone deacetylase 8 in complex with trapoxin A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone deacetylase 8 | polymer | 372 | 41161.8 | 1 | UniProt (Q9BY41) Pfam (PF00850) In PDB | Homo sapiens (Human) | HD8 |
2 | B | Trapoxin A | polymer | 4 | 638.8 | 1 | BIRD (PRD_002282) | Helicoma ambiens | (3S,6S,9S,15aR)-6,9-dibenzyl-3-{6,6-dihydroxy-6-[(2S)-oxiran-2-yl]hexyl}octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone |
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
6 | A | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 2 | Chemie (DIO) | |||
7 | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A: 8 - 377 (UniProt: Q9BY41)
PDB | External Database | Details |
---|---|---|
Ser 6 | - | expression tag |
Asn 7 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 41800.5 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 940.5 | |
All* | Total formula weight | 42741.0 |