8IYA
| Complex of SETDB1-derived peptide bound to UBE2E1 | Descriptor: | Histone-lysine N-methyltransferase SETDB1, SULFATE ION, Ubiquitin-conjugating enzyme E2 E1 | Authors: | Du, Y.X, Liu, L. | Deposit date: | 2023-04-04 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Complex of SETDB1-derived peptide bound to UBE2E1 To Be Published
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8IFG
| Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe | Descriptor: | Chromatin modification-related protein eaf3, Cph1, Cph2, ... | Authors: | Zhang, H.Q, Wang, X, Wang, Y.N, Liu, S.M, Zhang, Y, Xu, K, Ji, L.T, Kornberg, R.D. | Deposit date: | 2023-02-17 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Class I histone deacetylase complex: Structure and functional correlates. Proc Natl Acad Sci U S A, 120, 2023
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8CO7
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8WG5
| Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome | Descriptor: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | Authors: | Ai, H.S, He, Z.Z, Deng, Z.H, Liu, L. | Deposit date: | 2023-09-20 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome To Be Published
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8X72
| The Crystal Structure of PLK1 from Biortus. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, F, Cheng, W, Yuan, Z, Lin, D, Wu, B. | Deposit date: | 2023-11-22 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Crystal Structure of PLK1 from Biortus. To Be Published
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8QFL
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8QFN
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8QEZ
| Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution | Descriptor: | 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, CACODYLATE ION, ... | Authors: | Dorosz, J, Laulumaa, S, Frydenvang, K, Kastrup, J.S. | Deposit date: | 2023-09-01 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. Eur.J.Med.Chem., 264, 2023
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8QFQ
| Ergothioneine dioxygenase, variant H147A, from Thermocatellispora tengchongensis in complex with manganese | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Cysteine dioxygenase, ... | Authors: | Vasseur, C.M, Seebeck, F.P. | Deposit date: | 2023-09-04 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Enzyme-Catalyzed Oxidative Degradation of Ergothioneine. Angew.Chem.Int.Ed.Engl., 63, 2024
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8QFO
| Ergothioneine dioxygenase, variant Y149F, from Thermocatellispora tengchongensis in complex with manganese | Descriptor: | ACETATE ION, Cysteine dioxygenase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Vasseur, C.M, Seebeck, F.P. | Deposit date: | 2023-09-04 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Enzyme-Catalyzed Oxidative Degradation of Ergothioneine. Angew.Chem.Int.Ed.Engl., 63, 2024
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8HVQ
| Crystal structure of haloacid dehalogenase-like hydrolase family enzyme from Staphylococcus lugdunensis | Descriptor: | 1,2-ETHANEDIOL, Cof-type HAD-IIB family hydrolase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kaur, H, Mahto, J.K, Kumar, P, Sharma, A.K. | Deposit date: | 2022-12-27 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Crystal structure of haloacid dehalogenase-like hydrolase family enzyme from Staphylococcus lugdunensis To Be Published
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8C0M
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8BZ6
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8SWI
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8JC3
| Crystal structure of the P450 BM3 heme domain mutant F87A-T268V in complex with Pyd-N-C4-Phe and hydroxylamine | Descriptor: | 4-(pyridin-4-ylamino)butanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ... | Authors: | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | Deposit date: | 2023-05-10 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | C(sp3)-H hydroxylation of Broad-Spectrum Alkanes Catalyzed by an Artificial P450 Peroxygenase Driven by omega-Pyridyl Fatty Acyl Amino Acids. Mol Catal, 550, 2023
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8JC4
| Crystal structure of the P450 BM3 heme domain mutant F87A-T268V in complex with Pyd-Pid-Phe and hydroxylamine | Descriptor: | 1-pyridin-4-ylpiperidine-4-carboxylic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ... | Authors: | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | Deposit date: | 2023-05-10 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | C(sp3)-H hydroxylation of Broad-Spectrum Alkanes Catalyzed by an Artificial P450 Peroxygenase Driven by omega-Pyridyl Fatty Acyl Amino Acids. Mol Catal, 550, 2023
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8CBN
| structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | Authors: | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | Deposit date: | 2023-01-25 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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8JWU
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8JWS
| ePHD domain of PHD Finger Protein 7 (PHF7) | Descriptor: | 1,2-ETHANEDIOL, PHD finger protein 7, ZINC ION | Authors: | Bang, I, Lee, H.S, Choi, H.-J. | Deposit date: | 2023-06-29 | Release date: | 2023-12-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular basis for PHF7-mediated ubiquitination of histone H3. Genes Dev., 37, 2023
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8JWJ
| PHD Finger Protein 7 (PHF7) in complex with UBE2D2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, PHD finger protein 7, ... | Authors: | Lee, H.S, Bang, I, Choi, H.-J. | Deposit date: | 2023-06-29 | Release date: | 2023-12-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Molecular basis for PHF7-mediated ubiquitination of histone H3. Genes Dev., 37, 2023
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8CIB
| Structural and functional analysis of the Pseudomonas aeruginosa PA1677 protein | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Cysteine hydrolase, ... | Authors: | Sonnleitner, E, Brear, P, Luisi, B.F, Blasi, U. | Deposit date: | 2023-02-09 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control. Front Microbiol, 14, 2023
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8U5D
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8UJY
| Crystal structure of human WD repeat-containing protein 5 in complex with 4-(3,5-dimethoxybenzyl)-9-(4-fluoro-2-methylphenyl)-7-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (compound 8) | Descriptor: | (9P)-4-[(3,5-dimethoxyphenyl)methyl]-9-(4-fluoro-2-methylphenyl)-7-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-3,4-dihydro-1,4-benzoxazepin-5(2H)-one, WD repeat-containing protein 5 | Authors: | Zhao, B, Amporndanai, K, Fesik, S.W. | Deposit date: | 2023-10-11 | Release date: | 2023-12-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors. J.Med.Chem., 66, 2023
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8U1W
| Structure of Norovirus (Hu/GII.4/Sydney/NSW0514/2012/AU) protease bound to inhibitor NV-004 | Descriptor: | ACETATE ION, GLYCEROL, Peptidase C37, ... | Authors: | Eruera, A.R, Campbell, A.C, Krause, K.L. | Deposit date: | 2023-09-03 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Crystal Structure of Inhibitor-Bound GII.4 Sydney 2012 Norovirus 3C-Like Protease. Viruses, 15, 2023
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8U5E
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