8IG9
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8IG6
| Crystal structure of MERS main protease in complex with GC376 | Descriptor: | N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, ORF1a | Authors: | Lin, C, Zhang, J, Li, J. | Deposit date: | 2023-02-20 | Release date: | 2024-03-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
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8IGA
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8Q71
| Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the inhibitor GC-67 | Descriptor: | (2~{S})-1-(3,4-dichlorophenyl)-4-(4-methoxypyridin-3-yl)carbonyl-~{N}-(thiophen-2-ylmethyl)piperazine-2-carboxamide, 3C-like proteinase nsp5 | Authors: | Strater, N, Muller, C.E, Sylvester, K, Weisse, R.H, Useini, A, Gao, S, Song, L, Liu, Z, Zhan, P. | Deposit date: | 2023-08-15 | Release date: | 2023-12-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.322 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability. J.Med.Chem., 66, 2023
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8SXR
| Crystal structure of SARS-CoV-2 Mpro with C5a | Descriptor: | 3C-like proteinase nsp5, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(5-hydroxyisoquinolin-4-yl)acetamide | Authors: | Worrall, L.J, Kenward, C, Lee, J, Strynadka, N.C.J. | Deposit date: | 2023-05-23 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.114 Å) | Cite: | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerg Microbes Infect, 12, 2023
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8TBE
| Co-crystal structure of SARS-CoV-2 Mpro with Pomotrelvir | Descriptor: | 3C-like proteinase nsp5, Pomotrelvir bound form | Authors: | Olland, A, Fontano, E, White, A. | Deposit date: | 2023-06-28 | Release date: | 2023-08-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Evaluation of in vitro antiviral activity of SARS-CoV-2 M pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions. Antimicrob.Agents Chemother., 67, 2023
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8UYE
| BtCoV-HKU5 5' proximal stem-loop 5, conformation 1 | Descriptor: | BtCoV-HKU5 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYL
| MERS 5' proximal stem-loop 5, conformation 2 | Descriptor: | MERS 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYG
| BtCoV-HKU5 5' proximal stem-loop 5, conformation 2 | Descriptor: | RNA (135-MER) | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYK
| MERS 5' proximal stem-loop 5, conformation 1 | Descriptor: | MERS 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYJ
| BtCoV-HKU5 5' proximal stem-loop 5, conformation 4 | Descriptor: | BtCoV-HKU5 5' proximal stem-loop 5, conformation 4 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.3 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYS
| SARS-CoV-2 5' proximal stem-loop 5 | Descriptor: | SARS-CoV-2 RNA SL5 domain. | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-14 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYM
| MERS 5' proximal stem-loop 5, conformation 3 | Descriptor: | MERS 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYP
| SARS-CoV-1 5' proximal stem-loop 5 | Descriptor: | SARS-CoV-1 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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7USB
| CCoV-HuPn-2018 S in the swung out conformation (local refinement of domain 0) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2022-04-23 | Release date: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein. Cell, 185, 2022
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7US9
| CCoV-HuPn-2018 S in the proximal conformation (local refinement of domain 0) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2022-04-23 | Release date: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein. Cell, 185, 2022
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7USA
| Structure of the human coronavirus CCoV-HuPn-2018 spike glycoprotein with domain 0 in the swung out conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2022-04-23 | Release date: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein. Cell, 185, 2022
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7US6
| Structure of the human coronavirus CCoV-HuPn-2018 spike glycoprotein with domain 0 in the proximal conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2022-04-23 | Release date: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein. Cell, 185, 2022
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7VPP
| Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ji, W, Xu, Y, Zhang, S. | Deposit date: | 2021-10-17 | Release date: | 2022-03-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structures of a deltacoronavirus spike protein bound to porcine and human receptors. Nat Commun, 13, 2022
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7VPQ
| Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ji, W, Xu, Y, Zhang, S. | Deposit date: | 2021-10-17 | Release date: | 2022-03-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of a deltacoronavirus spike protein bound to porcine and human receptors. Nat Commun, 13, 2022
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