PDB: 13413 resultsInfo pagesStatus searchChemie searchBIRD

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6AEC	Binary complex of human DNA Polymerase Mu with MnATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... Authors: Chang, Y.K, Wu, W.J, Tsai, M.D. Deposit date: 2018-08-04 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
6AEH	Binary complex of human DNA Polymerase Mu with MnUTP Descriptor: DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, SULFATE ION, ... Authors: Chang, Y.K, Wu, W.J, Tsai, M.D. Deposit date: 2018-08-04 Release date: 2019-05-29 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
6AK6	Binary Complex of Human DNA Polymerase Mu with MnCTP Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... Authors: Chang, Y.K, Wu, W.J, Tsai, M.D. Deposit date: 2018-08-30 Release date: 2019-05-29 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
3ERC	Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase with three fragments of RNA and 3'-deoxy ATP Descriptor: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, ... Authors: Li, C, Li, H, Zhou, S, Poulos, T.L, Gershon, P.D. Deposit date: 2008-10-01 Release date: 2009-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.21 Å) Cite: Polymerase Translocation with Respect to Single-Stranded Nucleic Acid: Looping or Wrapping of Primer around a Poly(A) Polymerase Structure, 17, 2009
3ER8	Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase complex with two fragments of RNA Descriptor: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, Poly(A) polymerase catalytic subunit, RNA/DNA chimera 5'-D(CP*CP*)R(UP*UP*)D(C)-3', ... Authors: Li, C, Li, H, Zhou, S, Poulos, T.L, Gershon, P.D. Deposit date: 2008-10-01 Release date: 2009-06-16 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.18 Å) Cite: Polymerase Translocation with Respect to Single-Stranded Nucleic Acid: Looping or Wrapping of Primer around a Poly(A) Polymerase Structure, 17, 2009
6IRX	Crystal structure of the zebrafish cap-specific adenosine methyltransferase Descriptor: PDX1 C-terminal-inhibiting factor 1 Authors: Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. Deposit date: 2018-11-14 Release date: 2018-12-05 Last modified: 2020-10-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. Science, 363, 2019
6IRY	Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH Descriptor: 1,2-ETHANEDIOL, PDX1 C-terminal-inhibiting factor 1, S-ADENOSYL-L-HOMOCYSTEINE Authors: Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. Deposit date: 2018-11-14 Release date: 2018-12-05 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. Science, 363, 2019
8GWO	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-11-30 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWG	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWI	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWN	A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527 Descriptor: Helicase, Non-structural protein 7, Non-structural protein 8, ... Authors: Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2022-12-14 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
8GWF	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.Y, Huang, Y.C, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2023-01-11 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
7KSX	DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mg2+ (30min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSY	DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mg2+ (960min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.577 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSW	DNA Polymerase Mu, dGTP:Ct Reaction State Ternary Complex, 10 mM Mg2+ (10min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSV	DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mn2+ (960min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
3LKH	Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides Descriptor: 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide, RNA-directed RNA polymerase Authors: Lesburg, C.A. Deposit date: 2010-01-27 Release date: 2010-03-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides. Bioorg.Med.Chem.Lett., 20, 2010
7KST	DNA Polymerase Mu, dGTP:Ct Reaction State Ternary Complex, 10 mM Mn2+ (2min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KT9	DNA Polymerase Mu, 8-oxodGTP:At Product State Ternary Complex, 50 mM Mg2+ (960min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.482 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KT6	DNA Polymerase Mu, 8-oxodGTP:At Product State Ternary Complex, 10 mM Mn2+ (960min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KT5	DNA Polymerase Mu, 8-oxodGTP:At Product State Ternary Complex, 10 mM Mn2+ (120min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KTA	DNA Polymerase Mu, 8-oxodGTP:Ct Pre-Catalytic Ground State Ternary Complex, 20 mM Ca2+ (120min) Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.844 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KTF	DNA Polymerase Mu, 8-oxodGTP:Ct Product State Ternary Complex, 50 mM Mg2+ (180min) Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*CP*TP*AP*CP*G)-3'), ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.489 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KT8	DNA Polymerase Mu, 8-oxodGTP:At Product State Ternary Complex, 50 mM Mg2+ (180min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.701 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KT3	DNA Polymerase Mu, 8-oxodGTP:At Pre-Catalytic Ground State Ternary Complex, 20 mM Ca2+ (120min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.879 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021

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