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8UJV	Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide opposite urea lesion Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Tomar, R, Egli, M, Stone, M.P. Deposit date: 2023-10-11 Release date: 2024-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63, 2024
8UJX	Crystal structure of human polymerase eta with incoming dGMPnPP nucleotide opposite urea lesion Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Tomar, R, Egli, M, Stone, M.P. Deposit date: 2023-10-11 Release date: 2024-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63, 2024
8V7I	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 1 mM Mg2+ for 1800s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 1 mM Mg2+ for 1800s To Be Published
8V7C	Human DNA polymerase eta-DNA-dT primer gemCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion Descriptor: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Human DNA polymerase eta-DNA-dT primer gemCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7K	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 10 mM Mn2+ for 1800s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 10 mM Mn2+ for 1800s To Be Published
8V7A	Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7J	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 20 mM Mg2+ for 600s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 20 mM Mg2+ for 600s To Be Published
8V7F	Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ To Be Published
8V7H	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7B	Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion Descriptor: 4-amino-1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7E	Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ To Be Published
8V7D	Human DNA polymerase eta-DNA-dT primer rCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion Descriptor: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Human DNA polymerase eta-DNA-dT primer rCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7G	Human DNA polymerase eta-DNA-gemC-ended primer-dAMPNPP ternary complex with Mg2+ Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*(U7B))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... Authors: Chang, C, Gao, Y. Deposit date: 2023-12-04 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ To Be Published
3OHB	Yeast DNA polymerase eta extending from an 8-oxoG lesion Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*GP*(8OG)P*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Jain, R, Aggarwal, A.K. Deposit date: 2010-08-17 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Structure, 18, 2010
4DL6	Human DNA polymerase eta extending primer immediately after cisplatin crosslink (Pt-GG3). Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Cisplatin, DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*CP*C)-3'), ... Authors: Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W. Deposit date: 2012-02-05 Release date: 2012-05-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta Proc.Natl.Acad.Sci.USA, 109, 2012
3OHA	Yeast DNA polymerase eta inserting dCTP opposite an 8oxoG lesion Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(P*TP*(8OG)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... Authors: Silverstein, T.D, Jain, R, Aggarwal, A.K. Deposit date: 2010-08-17 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Structure, 18, 2010
5KFK	Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 300s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFU	Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 80s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFA	Human DNA polymerase eta-DNA ternary complex: ground state at pH7.0 (K+ MES) with 1 Ca2+ ion Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFJ	Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 180s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFV	Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 140s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KG7	Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 10 mM Zn2+ for 60s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*A)-3'), ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFD	Human DNA polymerase eta-DNA ternary complex: reaction with 1 mM Mn2+ for 300s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFN	Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: reaction with 1 mM Mg2+ for 1800s Descriptor: 2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFZ	Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 5 mM Mn2+ for 60s at 14 degree Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, ... Authors: Gao, Y, Yang, W. Deposit date: 2016-06-12 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

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