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2QWH	THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
2QWA	THE X-RAY STRUCTURE OF A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
2QWJ	THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-N-acetyl-4-amino-6-diethyl carboxamide-4,5-dihydro-2H-pyran-2-carboxylic acid, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
2HT7	N8 neuraminidase in open complex with oseltamivir Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, Neuraminidase Authors: Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. Deposit date: 2006-07-25 Release date: 2006-09-05 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2QWG	THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-N-acetyl-4-amino-6-diethyl carboxamide-4,5-dihydro-2H-pyran-2-carboxylic acid, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
3SAL	Crystal Structure of Influenza A Virus Neuraminidase N5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... Authors: Wang, M.Y, Qi, J.X, Liu, Y, Vavricka, C.J, Wu, Y, Li, Q, Gao, G.F. Deposit date: 2011-06-03 Release date: 2011-08-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Influenza a virus n5 neuraminidase has an extended 150-cavity J.Virol., 85, 2011
2HTU	N8 neuraminidase in complex with peramivir Descriptor: 3-(1-ACETYLAMINO-2-ETHYL-BUTYL)-4-GUANIDINO-2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID, Neuraminidase Authors: Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. Deposit date: 2006-07-26 Release date: 2006-09-05 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2HTW	N4 neuraminidase in complex with DANA Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, Neuraminidase Authors: Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. Deposit date: 2006-07-26 Release date: 2006-09-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2QWB	THE X-RAY STRUCTURE OF A COMPLEX OF SIALIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
2QWC	THE X-RAY STRUCTURE OF A COMPLEX OF NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
2HU0	N1 neuraminidase in complex with oseltamivir 1 Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, Neuraminidase Authors: Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. Deposit date: 2006-07-26 Release date: 2006-09-05 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.95 Å) Cite: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2HTY	N1 neuraminidase Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. Deposit date: 2006-07-26 Release date: 2006-09-05 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2HU4	N1 neuraminidase in complex with oseltamivir 2 Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, Neuraminidase Authors: Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. Deposit date: 2006-07-26 Release date: 2006-09-05 Last modified: 2018-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
2HT8	N8 neuraminidase in complex with oseltamivir Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, Neuraminidase Authors: Russell, R.J, Haire, L.F, Stevens, D.J, Collins, P.J, Lin, Y.P, Blackburn, G.M, Hay, A.J, Gamblin, S.J, Skehel, J.J. Deposit date: 2006-07-25 Release date: 2006-09-05 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature, 443, 2006
3SAN	Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Wang, M.Y, Qi, J.X, Liu, Y, Vavricka, C.J, Wu, Y, Li, Q, Gao, G.F. Deposit date: 2011-06-03 Release date: 2011-08-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Influenza a virus n5 neuraminidase has an extended 150-cavity J.Virol., 85, 2011
3TI8	Crystal structure of influenza A virus neuraminidase N5 complexed with laninamivir Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3W09	Influenza virus neuraminidase subtype N9 (TERN) complexed with 2,3-dif guanidino-neu5ac2en inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-3-fluoro-D-glycero-D-galacto-non-2-enonic acid, ... Authors: Streltsov, V.A. Deposit date: 2012-10-25 Release date: 2013-05-01 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity Science, 340, 2013
2QWD	THE X-RAY STRUCTURE OF A COMPLEX OF 4-AMINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
2QWI	THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-N-acetyl-4-guanidino-6-methyl(propyl) carboxamide-4,5-dihydro-2H-pyran-2-carboxylic acid, CALCIUM ION, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
3TI5	Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with Zanamivir Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3TI6	Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with oseltamivir Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-23 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3TIB	Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir octanoate Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-9-O-octanoyl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
2QWE	THE X-RAY STRUCTURE OF A COMPLEX OF 4-GUANIDINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Varghese, J.N. Deposit date: 1998-04-07 Release date: 1998-11-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6, 1998
3TI3	Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with laninamivir Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3TI4	Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with laninamivir octanoate Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-9-O-octanoyl-D-glycero-D-galacto-non-2-enonic acid, ACETATE ION, ... Authors: Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. Deposit date: 2011-08-20 Release date: 2011-11-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.602 Å) Cite: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011

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