3SAN

Crystal structure of influenza A virus neuraminidase N5 complexed with Zanamivir

Summary for 3SAN

• Entry DOI: 10.2210/pdb3san/pdb
• Related: 3NSS 3SAL
• Descriptor: Neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (7 entities in total)
• Functional Keywords: 6-bladed beta-propeller, hydrolase, calcium binding, glycosylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Total number of polymer chains: 2
• Total formula weight: 89468.24

Authors

Wang, M.Y.,Qi, J.X.,Liu, Y.,Vavricka, C.J.,Wu, Y.,Li, Q.,Gao, G.F. (deposition date: 2011-06-03, release date: 2011-08-10, Last modification date: 2024-10-09)

Primary citation

Wang, M.Y.,Qi, J.X.,Liu, Y.,Vavricka, C.J.,Wu, Y.,Li, Q.,Gao, G.F.
Influenza a virus n5 neuraminidase has an extended 150-cavity
J.Virol., 85:8431-8435, 2011

PubMed Abstract: There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding.

PubMed: 21653672
DOI: 10.1128/JVI.00638-11

Experimental method

X-RAY DIFFRACTION (1.6 Å)