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2HT7

N8 neuraminidase in open complex with oseltamivir

Summary for 2HT7
Entry DOI10.2210/pdb2ht7/pdb
Related2HT5 2HT8
DescriptorNeuraminidase, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid (2 entities in total)
Functional Keywordsn8, neuraminidase, oseltamivir, hydrolase
Biological sourceInfluenza A virus
Cellular locationVirion membrane (By similarity): Q07599
Total number of polymer chains1
Total formula weight43441.87
Authors
Russell, R.J.,Haire, L.F.,Stevens, D.J.,Collins, P.J.,Lin, Y.P.,Blackburn, G.M.,Hay, A.J.,Gamblin, S.J.,Skehel, J.J. (deposition date: 2006-07-25, release date: 2006-09-05, Last modification date: 2011-07-13)
Primary citationRussell, R.J.,Haire, L.F.,Stevens, D.J.,Collins, P.J.,Lin, Y.P.,Blackburn, G.M.,Hay, A.J.,Gamblin, S.J.,Skehel, J.J.
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.
Nature, 443:45-49, 2006
Cited by
PubMed: 16915235
DOI: 10.1038/nature05114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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