6MCB
| |
1E8K
| Cyclophilin 3 Complexed With Dipeptide Ala-Pro | Descriptor: | ALANINE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 3, PROLINE | Authors: | Wu, S.Y, Dornan, J, Kontopidis, G, Taylor, P, Walkinshaw, M.D. | Deposit date: | 2000-09-25 | Release date: | 2001-09-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The First Direct Determination of a Ligand Binding Constant in Protein Crystals Angew.Chem.Int.Ed.Engl., 40, 2001
|
|
8GXC
| |
8QCB
| CryoEM structure of a S. Cerevisiae Ski2387 complex in the open state | Descriptor: | Antiviral helicase SKI2, Antiviral protein SKI8, Superkiller protein 3, ... | Authors: | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | Deposit date: | 2023-08-25 | Release date: | 2023-11-08 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly. Mol.Cell, 83, 2023
|
|
3JCS
| 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania | Descriptor: | 26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S epsilon ribosomal RNA, ... | Authors: | Shalev-Benami, M, Zhang, Y, Matzov, D, Halfon, Y, Zackay, A, Rozenberg, H, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. | Deposit date: | 2016-01-21 | Release date: | 2016-07-20 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania. Cell Rep, 16, 2016
|
|
3X1O
| Crystal structure of the ROQ domain of human Roquin | Descriptor: | IODIDE ION, Roquin-1 | Authors: | Ose, T, Verma, A, Cockburn, J.B, Berrow, N.S, Alderton, D, Stuart, D, Owens, R.J, Jones, E.Y. | Deposit date: | 2014-11-26 | Release date: | 2015-03-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis Nat Commun, 6, 2015
|
|
5UI8
| structure of sigmaN-holoenzyme | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Darst, S.A, Campbell, E.A. | Deposit date: | 2017-01-13 | Release date: | 2017-02-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.76 Å) | Cite: | Crystal structure of Aquifex aeolicus sigma (N) bound to promoter DNA and the structure of sigma (N)-holoenzyme. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
7ORI
| La Crosse virus polymerase at replication late-elongation stage | Descriptor: | La Crosse virus polymerase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | Deposit date: | 2021-06-06 | Release date: | 2022-02-16 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
|
|
7W2P
| Tudor domain of SMN in complex with a small molecule | Descriptor: | 2-[(4-fluorophenyl)methyl]-2-azatricyclo[7.3.0.0^{3,7}]dodeca-1(9),3(7)-dien-8-imine, MAGNESIUM ION, Survival motor neuron protein, ... | Authors: | Li, W, Arrowsmith, C.H, Edwards, A.M, Liu, Y, Min, J. | Deposit date: | 2021-11-24 | Release date: | 2022-10-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13, 2022
|
|
7W30
| Tudor domain of SMN in complex with a small molecule | Descriptor: | 1,2-dimethylquinolin-4-imine, Survival motor neuron protein, UNKNOWN ATOM OR ION | Authors: | Li, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Liu, Y, Min, J. | Deposit date: | 2021-11-24 | Release date: | 2022-10-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13, 2022
|
|
7MI2
| Seb1-G476S RNA binding domain | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Rpb7-binding protein seb1 | Authors: | Jacewicz, A, Shuman, S. | Deposit date: | 2021-04-16 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
1KC8
| Co-crystal Structure of Blasticidin S Bound to the 50S Ribosomal Subunit | Descriptor: | 23S RRNA, 5S RRNA, BLASTICIDIN S, ... | Authors: | Hansen, J.L, Ban, N, Nissen, P, Moore, P.B, Steitz, T.A. | Deposit date: | 2001-11-07 | Release date: | 2003-07-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of
the Large Ribosomal Subunit J.Mol.Biol., 330, 2003
|
|
7MPF
| The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000986436 | Descriptor: | 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | Authors: | Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. | Deposit date: | 2021-05-04 | Release date: | 2022-05-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
|
|
8IGD
| |
6FAD
| SR protein kinase 1 (SRPK1) in complex with the RGG-box of HSV1 ICP27 | Descriptor: | PHOSPHATE ION, SRSF protein kinase 1, mRNA export factor | Authors: | Tunnicliffe, R.B, Levy, C, Mould, A.P, Mckenzie, E.A, Sandri-Goldin, R.M, Golovanov, A.P. | Deposit date: | 2017-12-15 | Release date: | 2019-09-25 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27. Mbio, 10, 2019
|
|
4RBY
| |
4RC0
| |
6FBL
| NMR Solution Structure of MINA-1(254-334) | Descriptor: | MINA-1 | Authors: | Michel, E, Allain, F. | Deposit date: | 2017-12-19 | Release date: | 2019-01-30 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Cell Death Differ., 26, 2019
|
|
5FT0
| Crystal structure of gp37(Dip) from bacteriophage phiKZ | Descriptor: | ARGININE, GP37, POTASSIUM ION | Authors: | Van den Bossche, A, Hardwick, S.W, Ceyssens, P.J, Hendrix, H, Voet, M, Dendooven, T, Bandyra, K.J, De Maeyer, M, Aertsen, A, Noben, J.P, Luisi, B.F, Lavigne, R. | Deposit date: | 2016-01-08 | Release date: | 2016-08-03 | Last modified: | 2017-03-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome. Elife, 5, 2016
|
|
4RBZ
| |
7ORO
| La Crosse virus polymerase at replication early-elongation stage | Descriptor: | La Crosse virus polymerase, MAGNESIUM ION, RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | Deposit date: | 2021-06-06 | Release date: | 2022-02-16 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
|
|
7O0G
| |
6GTG
| Transition state structure of Cpf1(Cas12a) I4 conformation | Descriptor: | CRISPR-associated endonuclease Cas12a, DNA (32-MER), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*AP*GP*T)-3'), ... | Authors: | Mesa, P, Montoya, G, Stella, S. | Deposit date: | 2018-06-18 | Release date: | 2018-12-19 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 175, 2018
|
|
8C9C
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L22, 50S ribosomal protein L24, ... | Authors: | Nikolay, R, Qin, B, Lauer, S. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (6.62 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
|
|
1HJB
| |