5X4Q
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![BU of 5x4q by Molmil](/molmil-images/mine/5x4q) | Crystal structure of the BCL6 BTB domain in complex with Compound 7 | Descriptor: | 1,2-ETHANEDIOL, 5-[[5-chloranyl-2-(pyridin-3-ylmethylamino)pyrimidin-4-yl]amino]-1,3-dihydroindol-2-one, B-cell lymphoma 6 protein, ... | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2017-02-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
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5X4M
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![BU of 5x4m by Molmil](/molmil-images/mine/5x4m) | Crystal structure of the BCL6 BTB domain in complex with Compound 1 | Descriptor: | B-cell lymphoma 6 protein, N-phenyl-1,3,5-triazine-2,4-diamine | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2017-02-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
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5X4P
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![BU of 5x4p by Molmil](/molmil-images/mine/5x4p) | Crystal structure of the BCL6 BTB domain in complex with Compound 6 | Descriptor: | 5-[(5-chloranylpyrimidin-4-yl)amino]-1,3-dihydroindol-2-one, B-cell lymphoma 6 protein | Authors: | Sogabe, S, Ida, K, Lane, W, Snell, G. | Deposit date: | 2017-02-13 | Release date: | 2017-05-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
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5NVL
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![BU of 5nvl by Molmil](/molmil-images/mine/5nvl) | Crystal structure of the human 4EHP-GIGYF2 complex | Descriptor: | Eukaryotic translation initiation factor 4E type 2, GRB10-interacting GYF protein 2 | Authors: | Peter, D, Valkov, E. | Deposit date: | 2017-05-04 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31, 2017
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1BDT
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![BU of 1bdt by Molmil](/molmil-images/mine/1bdt) | WILD TYPE GENE-REGULATING PROTEIN ARC/DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*AP*TP*GP*AP*TP*AP*GP*AP*AP*GP*CP*AP*CP*TP*CP*TP*AP*CP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*GP*TP*AP*GP*AP*GP*TP*GP*CP*TP*TP*CP*TP*AP*TP*CP*AP*T)-3'), PROTEIN (GENE-REGULATING PROTEIN ARC) | Authors: | Schilbach, J.F, Karzai, A.W, Raumann, B.E, Sauer, R.T. | Deposit date: | 1998-05-11 | Release date: | 1999-02-16 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Origins of DNA-binding specificity: role of protein contacts with the DNA backbone. Proc.Natl.Acad.Sci.USA, 96, 1999
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7JU2
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![BU of 7ju2 by Molmil](/molmil-images/mine/7ju2) | Crystal structure of the monomeric ETV6 PNT domain | Descriptor: | FORMIC ACID, Transcription factor ETV6 | Authors: | Gerak, C.A.N, Kolesnikov, M, Murphy, M.E.P, McIntosh, L.P. | Deposit date: | 2020-08-19 | Release date: | 2021-01-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85002184 Å) | Cite: | Biophysical characterization of the ETV6 PNT domain polymerization interfaces. J.Biol.Chem., 296, 2021
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8PDE
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![BU of 8pde by Molmil](/molmil-images/mine/8pde) | Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC4 deacetylase binding motif | Descriptor: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), HDAC4 (histone deacetylase 4) binding motif peptide:GSGEVKMKLQEFVLNKK, ... | Authors: | Chinellato, M, Carli, A, Perin, S, Mazzocato, Y, Biondi, B, Di Giorgio, E, Brancolini, C, Angelini, A, Cendron, L. | Deposit date: | 2023-06-12 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436, 2024
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3DNV
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![BU of 3dnv by Molmil](/molmil-images/mine/3dnv) | MDT Protein | Descriptor: | DNA (5'-D(*DAP*DCP*DTP*DAP*DTP*DCP*DCP*DCP*DCP*DTP*DTP*DAP*DAP*DGP*DGP*DGP*DGP*DAP*DTP*DAP*DG)-3'), HTH-type transcriptional regulator hipB, Protein hipA, ... | Authors: | schumacher, M.A. | Deposit date: | 2008-07-02 | Release date: | 2009-01-27 | Last modified: | 2023-04-05 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science, 323, 2009
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2O9A
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![BU of 2o9a by Molmil](/molmil-images/mine/2o9a) | The crystal structure of the E.coli IclR C-terminal fragment in complex with pyruvate. | Descriptor: | 1,2-ETHANEDIOL, Acetate operon repressor, PYRUVIC ACID | Authors: | Lunin, V.V, Ezersky, A, Evdokimova, E, Kudritska, M, Savchenko, A. | Deposit date: | 2006-12-13 | Release date: | 2007-04-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Glyoxylate and Pyruvate Are Antagonistic Effectors of the Escherichia coli IclR Transcriptional Regulator. J.Biol.Chem., 282, 2007
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6YC6
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![BU of 6yc6 by Molmil](/molmil-images/mine/6yc6) | Structure of C. glutamicum GlnK | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, PII protein | Authors: | Grau, F.C, Muller, Y.A. | Deposit date: | 2020-03-18 | Release date: | 2021-03-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of adenylylated and unadenylylated P II protein GlnK from Corynebacterium glutamicum. Acta Crystallogr D Struct Biol, 77, 2021
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6YC7
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![BU of 6yc7 by Molmil](/molmil-images/mine/6yc7) | Structure of adenylylated C. glutamicum GlnK | Descriptor: | ADENINE ARABINOSE-5'-PHOSPHATE, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Grau, F.C, Muller, Y.A. | Deposit date: | 2020-03-18 | Release date: | 2021-03-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of adenylylated and unadenylylated P II protein GlnK from Corynebacterium glutamicum. Acta Crystallogr D Struct Biol, 77, 2021
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4S0R
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![BU of 4s0r by Molmil](/molmil-images/mine/4s0r) | Structure of GS-TnrA complex | Descriptor: | GLUTAMINE, Glutamine synthetase, MAGNESIUM ION, ... | Authors: | Schumacher, M.A, Chinnam, N.G, Cuthbert, B, Tonthat, N.K. | Deposit date: | 2015-01-04 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. Genes Dev., 29, 2015
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5KIP
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![BU of 5kip by Molmil](/molmil-images/mine/5kip) | |
2WA4
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![BU of 2wa4 by Molmil](/molmil-images/mine/2wa4) | FACTOR INHIBITING HIF-1 ALPHA WITH N,3-dihydroxybenzamide | Descriptor: | FE (II) ION, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, N,3-DIHYDROXYBENZAMIDE, ... | Authors: | Conejo-Garcia, A, Lienard, B.M.R, Clifton, I.J, McDonough, M.A, Schofield, C.J. | Deposit date: | 2009-02-02 | Release date: | 2010-04-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg. Med. Chem. Lett., 20, 2010
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6QEC
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![BU of 6qec by Molmil](/molmil-images/mine/6qec) | DNA binding domain of LUX ARRYTHMO in complex with DNA | Descriptor: | DNA (5'-D(*AP*TP*TP*CP*GP*AP*AP*TP*AP*T*TP*AP*TP*AP*TP*TP*CP*GP*AP*A)-3'), GLYCEROL, Transcription factor LUX | Authors: | Zubieta, C, Nayak, A. | Deposit date: | 2019-01-07 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular mechanisms of Evening Complex activity inArabidopsis. Proc.Natl.Acad.Sci.USA, 117, 2020
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3OHU
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![BU of 3ohu by Molmil](/molmil-images/mine/3ohu) | Crystal structure of the human Bach2 POZ domain, form I | Descriptor: | Transcription regulator protein BACH2 | Authors: | Rosbrook, G.O, Stead, M.A, Carr, S.B, Wright, S.C. | Deposit date: | 2010-08-18 | Release date: | 2011-11-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond. Acta Crystallogr.,Sect.D, 68, 2012
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3OHV
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![BU of 3ohv by Molmil](/molmil-images/mine/3ohv) | Crystal structure of the human Bach2 POZ domain, form II | Descriptor: | Transcription regulator protein BACH2 | Authors: | Rosbrook, G.O, Stead, M.A, Carr, S.B, Wright, S.C. | Deposit date: | 2010-08-18 | Release date: | 2011-11-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond. Acta Crystallogr.,Sect.D, 68, 2012
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6RJK
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![BU of 6rjk by Molmil](/molmil-images/mine/6rjk) | Structure of virulence factor SghA from Agrobacterium tumefaciens | Descriptor: | Beta-glucosidase | Authors: | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | Deposit date: | 2019-04-27 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.922 Å) | Cite: | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
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6RJM
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![BU of 6rjm by Molmil](/molmil-images/mine/6rjm) | Complex structure of virulence factor SghA and its hydrolysis product glucose | Descriptor: | Beta-glucosidase, alpha-D-glucopyranose | Authors: | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | Deposit date: | 2019-04-27 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.112 Å) | Cite: | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
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6RJO
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![BU of 6rjo by Molmil](/molmil-images/mine/6rjo) | Complex structure of virulence factor SghA with its substrate analog salicin | Descriptor: | 2-(hydroxymethyl)phenyl beta-D-glucopyranoside, Beta-glucosidase | Authors: | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | Deposit date: | 2019-04-28 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.804 Å) | Cite: | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
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6RK2
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![BU of 6rk2 by Molmil](/molmil-images/mine/6rk2) | Complex structure of virulence factor SghA mutant with its substrate SAG | Descriptor: | 2-(alpha-L-altropyranosyloxy)benzoic acid, Beta-glucosidase | Authors: | Ye, F.Z, Wang, C, Chang, C.Q, Zhang, L.H, Gao, Y.G. | Deposit date: | 2019-04-30 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals. Proc.Natl.Acad.Sci.USA, 116, 2019
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1NKD
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![BU of 1nkd by Molmil](/molmil-images/mine/1nkd) | |
6R1P
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![BU of 6r1p by Molmil](/molmil-images/mine/6r1p) | EthR ligand complex | Descriptor: | 2-[2-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2,3-triazol-1-yl]ethyl]-6-methyl-1~{H}-pyrimidin-4-one, HTH-type transcriptional regulator EthR | Authors: | Pohl, E, Tatum, N. | Deposit date: | 2019-03-14 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds. J Phys Chem Lett, 10, 2019
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6R1S
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![BU of 6r1s by Molmil](/molmil-images/mine/6r1s) | EthR ligand complex | Descriptor: | 2-(3-methylphenyl)-~{N}-[[2-(oxan-4-yl)-7-oxidanyl-pyrazolo[1,5-a]pyrimidin-5-yl]methyl]ethanamide, HTH-type transcriptional regulator EthR | Authors: | Pohl, E, Tatum, N. | Deposit date: | 2019-03-14 | Release date: | 2020-02-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds. J Phys Chem Lett, 10, 2019
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5HLH
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![BU of 5hlh by Molmil](/molmil-images/mine/5hlh) | Crystal structure of the overoxidized AbfR bound to DNA | Descriptor: | DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator | Authors: | Liu, G, Liu, X, Gan, J, Yang, C.-G. | Deposit date: | 2016-01-15 | Release date: | 2017-01-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc., 139, 2017
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