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1IF5	Carbonic Anhydrase II Complexed With 2,6-difluorobenzenesulfonamide Descriptor: 2,6-DIFLUOROBENZENESULFONAMIDE, Carbonic Anhydrase II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Christianson, D.W. Deposit date: 2001-04-12 Release date: 2001-05-02 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Binding of Fluorine Substituted Benzenesulfonamides to Carbonic Anhydrase II To be Published
1IF4	Carbonic Anhydrase II Complexed With 4-fluorobenzenesulfonamide Descriptor: 4-FLUOROBENZENESULFONAMIDE, Carbonic Anhydrase II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Christianson, D.W. Deposit date: 2001-04-12 Release date: 2001-05-02 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Binding of Fluorine Substituted Benzenesulfonamides to Carbonic Anhydrase II To be Published
1I9Q	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I9P	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I9O	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I9N	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I9M	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I9L	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W. Deposit date: 2001-03-20 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. J.Am.Chem.Soc., 123, 2001
1I91	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE Descriptor: 6-[N-(3-HYDROXY-PHENYL)-3-(MORPHOLIN-4-YLMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-1,1,-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W. Deposit date: 2001-03-16 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. J.Med.Chem., 45, 2002
1I90	CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R) Descriptor: 4-AMINO-6-[N-(3-METHOXYLPROPYL)-2H-THIENO[3,2-E][1,2]THIAZINE 1,1-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W. Deposit date: 2001-03-16 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. J.Med.Chem., 45, 2002
1I8Z	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE Descriptor: 6-[N-(3-METHOXY-PHENYL)-3-(MORPHOLIN-4-YLMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-1,1,-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W. Deposit date: 2001-03-16 Release date: 2001-03-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. J.Med.Chem., 45, 2002
1HVA	ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM Descriptor: CARBONIC ANHYDRASE II Authors: Alexander, R.S, Christianson, D.W. Deposit date: 1992-10-27 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. Biochemistry, 32, 1993
1HUH	DIFFERENCES IN ANIONIC INHIBITION OF HUMAN CARBONIC ANHYDRASE I REVEALED FROM THE STRUCTURES OF IODIDE AND GOLD CYANIDE INHIBITOR COMPLEXES Descriptor: CARBONIC ANHYDRASE I, IODIDE ION, ZINC ION Authors: Kumar, V, Kannan, K.K. Deposit date: 1993-10-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes. Acta Crystallogr.,Sect.D, 50, 1994
1HUG	Differences in anionic inhibition of Human Carbonic Anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes Descriptor: CARBONIC ANHYDRASE I, GOLD (I) CYANIDE ION, ZINC ION Authors: Kumar, V, Kannan, K.K. Deposit date: 1993-10-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes. Acta Crystallogr.,Sect.D, 50, 1994
1HED	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HEC	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HEB	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HEA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HCB	ENZYME-SUBSTRATE INTERACTIONS: STRUCTURE OF HUMAN CARBONIC ANHYDRASE I COMPLEXED WITH BICARBONATE Descriptor: BICARBONATE ION, CARBONIC ANHYDRASE I, ZINC ION Authors: Kumar, V, Kannan, K.K. Deposit date: 1994-01-07 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Enzyme-substrate interactions. Structure of human carbonic anhydrase I complexed with bicarbonate. J.Mol.Biol., 241, 1994
1HCA	UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-04-02 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II. J.Am.Chem.Soc., 113, 1991
1H9Q	H119Q CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1H9N	H119N CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1H4N	H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CARBONIC ANHYDRASE II, ZINC ION Authors: Lesburg, C.A, Christianson, D.W. Deposit date: 1997-05-29 Release date: 1997-09-17 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1G6V	Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase Descriptor: ANTIBODY HEAVY CHAIN, CARBONIC ANHYDRASE, ZINC ION Authors: Desmyter, A, Decanniere, K, Muyldermans, S, Wyns, L. Deposit date: 2000-11-08 Release date: 2000-11-22 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody. J.Biol.Chem., 276, 2001
1G54	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2,3,4,5,6-PENTAFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ... Authors: Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W. Deposit date: 2000-10-30 Release date: 2000-11-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II J.Am.Chem.Soc., 122, 2000

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