5HP1
 
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1IXY
 | | Ternary complex of T4 phage BGT with UDP and a 13 mer DNA duplex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-D(*CP*TP*AP*TP*CP*TP*GP*AP*GP*TP*AP*TP*C)-3', 5'-D(*GP*AP*TP*AP*CP*TP*3DRP*AP*GP*AP*TP*AP*G)-3', ... | | Authors: | Lariviere, L, Morera, S. | | Deposit date: | 2002-07-09 | | Release date: | 2002-12-04 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A Base-flipping Mechanism for the T4 Phage beta-Glucosyltransferase and Identification of a
Transition-state Analog
J.Mol.Biol., 324, 2002
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8Q3W
 | | ATP-bound IstB in complex to duplex DNA | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (48-MER) Target DNA FW, DNA (48-MER) Traget DNA Rv, ... | | Authors: | de la Gandara, A, Spinola-Amilibia, M, Araujo-Bazan, L, Nunez-Ramirez, R, Berger, J.M, Arias-Palomo, E. | | Deposit date: | 2023-08-04 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Molecular basis for transposase activation by a dedicated AAA+ ATPase.
Nature, 630, 2024
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7SFG
 | | Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Cofactor SAM | | Descriptor: | 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 1, DNA Strand 1, ... | | Authors: | Horton, J.R, Pathuri, S, Cheng, X. | | Deposit date: | 2021-10-03 | | Release date: | 2022-03-30 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.
Structure, 30, 2022
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3G0A
 | | Mth0212 with two bound manganese ions | | Descriptor: | Exodeoxyribonuclease, GLYCEROL, MANGANESE (II) ION, ... | | Authors: | Lakomek, K, Dickmanns, A, Ficner, R. | | Deposit date: | 2009-01-27 | | Release date: | 2010-03-09 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA
J.Mol.Biol., 399, 2010
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3ZQP
 | | Crystal structure of the small terminase oligomerization domain from a SPP1-like bacteriophage | | Descriptor: | TERMINASE SMALL SUBUNIT | | Authors: | Buttner, C.R, Chechik, M, Ortiz-Lombardia, M, Smits, C, Chechik, V, Jeschke, G, Dykeman, E, Benini, S, Alonso, J.C, Antson, A.A. | | Deposit date: | 2011-06-10 | | Release date: | 2011-12-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Basis for DNA Recognition and Loading Into a Viral Packaging Motor.
Proc.Natl.Acad.Sci.USA, 109, 2012
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5I42
 | | Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+) ion | | Descriptor: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (38-MER), ... | | Authors: | Das, K, Arnold, E. | | Deposit date: | 2016-02-11 | | Release date: | 2016-06-01 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.
Acs Chem.Biol., 11, 2016
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5L35
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3FZI
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4KPF
 | | Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate | | Descriptor: | (3aS,4R)-4-amino-13-cyclopropyl-8-fluoro-10-oxo-3a,4,5,6,10,13-hexahydro-1H,3H-pyrrolo[2',1':3,4][1,4]oxazepino[5,6-h]quinoline-11-carboxylic acid, E-site1, E-site2, ... | | Authors: | Laponogov, I, Pan, X.-S, Vesekov, D.A, Cirz, R.T, Wagman, A.S, Moser, H.E, Fisher, L.M, Sanderson, M.R. | | Deposit date: | 2013-05-13 | | Release date: | 2014-11-26 | | Last modified: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (3.24 Å) | | Cite: | Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.
Open Biol, 6, 2016
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2NP6
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3G1K
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2XCJ
 | | Crystal structure of P2 C, the immunity repressor of temperate E. coli phage P2 | | Descriptor: | C PROTEIN, FORMIC ACID, GLYCEROL, ... | | Authors: | Massad, T, Skaar, K, Hogbom, M, Stenmark, P. | | Deposit date: | 2010-04-23 | | Release date: | 2010-07-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of the P2 C-Repressor: A Binder of Non-Palindromic Direct DNA Repeats.
Nucleic Acids Res., 38, 2010
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1F4R
 | | CRYSTAL STRUCTURE OF THE HUMAN AAG DNA REPAIR GLYCOSYLASE COMPLEXED WITH 1,N6-ETHENOADENINE-DNA | | Descriptor: | 3-METHYL-ADENINE DNA GLYCOSYLASE, DNA (5'-D(*GP*AP*CP*AP*TP*GP*(EDA)P*TP*TP*GP*CP*CP*T)-3'), DNA (5'-D(*GP*GP*CP*AP*AP*TP*CP*AP*TP*GP*TP*CP*A)-3'), ... | | Authors: | Lau, A.Y, Wyatt, M.D, Glassner, B.J, Samson, L.D, Ellenberger, T. | | Deposit date: | 2000-06-08 | | Release date: | 2000-12-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.
Proc.Natl.Acad.Sci.USA, 97, 2000
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3G8V
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2MXE
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3U44
 | | Crystal structure of AddAB-DNA complex | | Descriptor: | ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease subunit A, DNA (36-MER), ... | | Authors: | Saikrishnan, K, Krajewski, W, Wigley, D. | | Deposit date: | 2011-10-07 | | Release date: | 2012-03-21 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.201 Å) | | Cite: | Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.
Embo J., 31, 2012
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3ON0
 | | Crystal structure of the pED208 TraM-sbmA complex | | Descriptor: | Protein traM, sbmA | | Authors: | Wong, J.J.W, Lu, J, Edwards, R.A, Frost, L.S, Mark Glover, J.N. | | Deposit date: | 2010-08-27 | | Release date: | 2011-05-25 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.874 Å) | | Cite: | Structural basis of cooperative DNA recognition by the plasmid conjugation factor, TraM.
Nucleic Acids Res., 39, 2011
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5FW2
 | | Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Bargsten, K, Jinek, M. | | Deposit date: | 2016-02-11 | | Release date: | 2016-06-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.676 Å) | | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
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5FW3
 | | Crystal structure of SpCas9 variant VRER bound to sgRNA and TGCG PAM target DNA | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Bargsten, K, Jinek, M. | | Deposit date: | 2016-02-11 | | Release date: | 2016-06-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
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3U4Q
 | | Structure of AddAB-DNA complex at 2.8 angstroms | | Descriptor: | 1,2-ETHANEDIOL, ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease subunit A, ... | | Authors: | Saikrishnan, K, Krajewski, W, Wigley, D. | | Deposit date: | 2011-10-10 | | Release date: | 2012-03-21 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex.
Embo J., 31, 2012
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1EWN
 | | CRYSTAL STRUCTURE OF THE HUMAN AAG DNA REPAIR GLYCOSYLASE COMPLEXED WITH 1,N6-ETHENOADENINE-DNA | | Descriptor: | 3-METHYL-ADENINE DNA GLYCOSYLASE, DNA (5'-D(*GP*AP*CP*AP*TP*GP*(EDA)P*TP*TP*GP*CP*C)-3'), DNA (5'-D(P*GP*CP*AP*AP*TP*CP*AP*TP*GP*TP*CP*A)-3'), ... | | Authors: | Lau, A.Y, Wyatt, M.D, Glassner, B.J, Samson, L.D, Ellenberger, T. | | Deposit date: | 2000-04-26 | | Release date: | 2000-12-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.
Proc.Natl.Acad.Sci.USA, 97, 2000
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4F0Q
 | | MspJI Restriction Endonuclease - P21 Form | | Descriptor: | MAGNESIUM ION, Restriction endonuclease | | Authors: | Horton, J.R, Mabuchi, M, Cohen-Karni, D, Zhang, X, Griggs, R, Samaranayake, M, Roberts, R.J, Zheng, Y, Cheng, X. | | Deposit date: | 2012-05-04 | | Release date: | 2012-08-08 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.046 Å) | | Cite: | Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease.
Nucleic Acids Res., 40, 2012
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8KAG
 | | Crystal structure of SpyCas9 in complex with sgRNA and target RNA | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, RNA (5'-R(*CP*CP*AP*CP*UP*UP*CP*AP*AP*UP*UP*AP*GP*AP*AP*CP*AP*CP*GP*GP*AP*CP*C)-3'), RNA (98-MER) | | Authors: | Chen, Y, Chen, J, Liu, L. | | Deposit date: | 2023-08-03 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (3.88 Å) | | Cite: | Trans-nuclease activity of Cas9 activated by DNA or RNA target binding.
Nat.Biotechnol., 2024
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8RCD
 | | RAD51 nucleoprotein filament on abasic single-stranded DNA | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*GP*GP*(3DR)P*AP*TP*(3DR)P*CP*AP*(3DR)P*TP*GP*(3DR)P*TP*AP*(3DR)P*AP*CP*(3DR)P*TP*GP*(3DR)P*GP*C)-3'), ... | | Authors: | Appleby, R, Pellegrini, L. | | Deposit date: | 2023-12-06 | | Release date: | 2024-09-04 | | Last modified: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | RAD51 protects abasic sites to prevent replication fork breakage.
Mol.Cell, 84, 2024
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