PDB: 594 resultsInfo pagesStatus searchChemie searchBIRD

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7RNU	nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8X	Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide Descriptor: EPOR pY454 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
8CZ9	Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide Descriptor: CHLORIDE ION, JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2022-05-24 Release date: 2023-05-31 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity. J.Exp.Med., 221, 2024
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV Descriptor: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-07 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide E683V variant, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-08 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
4EIH	Crystal structure of Arg SH2 domain Descriptor: Abelson tyrosine-protein kinase 2, CHLORIDE ION Authors: Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. Deposit date: 2012-04-05 Release date: 2013-04-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 Authors: Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. Deposit date: 2010-03-24 Release date: 2010-05-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
7WFY	Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide Descriptor: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2 Authors: Zhang, Y.J, Liu, Y.R, Wu, B. Deposit date: 2021-12-27 Release date: 2022-12-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.449 Å) Cite: Vav2 is a novel APP-interacting protein that regulates APP protein level. Sci Rep, 12, 2022
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
4EY0	Structure of tandem SH2 domains from PLCgamma1 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-01 Release date: 2012-10-31 Last modified: 2013-06-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
4F5A	Triple mutant Src SH2 domain bound to phosphate ion Descriptor: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F59	Triple mutant Src SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
4F5B	Triple mutant Src SH2 domain bound to phosphotyrosine Descriptor: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
1WQU	Solution structure of the human FES SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase FES/FPS Authors: Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-10-02 Release date: 2005-06-14 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes J.Biomol.NMR, 31, 2005
1X0N	NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor Descriptor: 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 Authors: Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. Deposit date: 2005-03-24 Release date: 2005-04-19 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor To be Published
1X6C	Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 Descriptor: Tyrosine-protein phosphatase, non-receptor type 6 Authors: Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-17 Release date: 2005-11-17 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 To be Published
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain Descriptor: Cytoplasmic protein NCK2 Authors: Ran, X, Song, J. Deposit date: 2005-03-14 Release date: 2005-03-29 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
8ATK	The SH2 domain of mouse SH2B1 Descriptor: SH2B adapter protein 1 Authors: Fowler, N.J, Williamson, M.P, Albalwi, M.F. Deposit date: 2022-08-23 Release date: 2023-05-24 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1. Structure, 31, 2023
4K44	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Hajicek, N, Sondek, J. Deposit date: 2013-04-11 Release date: 2013-06-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
4K45	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide Authors: Sondek, J, Hajicek, N. Deposit date: 2013-04-11 Release date: 2013-06-26 Last modified: 2014-01-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013

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