PDB: 595 resultsInfo pagesStatus searchChemie searchBIRD

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4K45	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide Authors: Sondek, J, Hajicek, N. Deposit date: 2013-04-11 Release date: 2013-06-26 Last modified: 2014-01-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
3US4	Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution Descriptor: Megakaryocyte-associated tyrosine-protein kinase, SULFATE ION Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-11-22 Release date: 2011-12-28 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution To be published
3UYO	Crystal structure of monobody SH13/ABL1 SH2 domain complex Descriptor: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Koide, A, Koide, S. Deposit date: 2011-12-06 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
1SPS	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PEPTIDE YEEI, SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1SKJ	COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX Descriptor: 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN Authors: Holland, D.R, Rubin, J.R. Deposit date: 1997-09-18 Release date: 1998-02-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997
1SHD	PEPTIDE INHIBITORS OF SRC SH3-SH2-PHOSPHOPROTEIN INTERACTIONS Descriptor: C-SRC TYROSINE KINASE SH2 DOMAIN, TRKA RECEPTOR Authors: Gilmer, T, Jordan, S. Deposit date: 1994-11-10 Release date: 1995-01-26 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem., 269, 1994
1SHB	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE B, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1SHA	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE A, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1TZE	SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2) Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 Authors: Rahuel, J, Grutter, M.G. Deposit date: 1996-06-06 Release date: 1997-07-07 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3, 1996
1SPR	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PHOSPHATE ION, SRC TYROSINE KINASE SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1WQU	Solution structure of the human FES SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase FES/FPS Authors: Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-10-02 Release date: 2005-06-14 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes J.Biomol.NMR, 31, 2005
2MC1	Solution structure of the Vav1 SH2 domain complexed with a Syk-derived singly phosphorylated peptide Descriptor: Proto-oncogene vav, Tyrosine-protein kinase SYK Authors: Chen, C, Piraner, D, Gorenstein, N.M, Geahlen, R.L, Post, C.B. Deposit date: 2013-08-13 Release date: 2013-08-28 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain. Biopolymers, 99, 2013
2MQI	human Fyn SH2 free state Descriptor: Tyrosine-protein kinase Fyn Authors: Huculeci, R, Buts, L, Lenaerts, T, VanNuland, N. Deposit date: 2014-06-20 Release date: 2015-07-29 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 2016
2MRK	Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide Descriptor: C-terminal Tyrosine-protein kinase Fyn, Tyrosine-protein kinase Fyn Authors: Huculeci, R, Buts, L, Lenaerts, A.J, van Nuland, N. Deposit date: 2014-07-09 Release date: 2015-07-15 Last modified: 2016-12-14 Method: SOLUTION NMR Cite: Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 2016
4EIH	Crystal structure of Arg SH2 domain Descriptor: Abelson tyrosine-protein kinase 2, CHLORIDE ION Authors: Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. Deposit date: 2012-04-05 Release date: 2013-04-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
5GJI	PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex Descriptor: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ... Authors: Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. Deposit date: 2016-06-30 Release date: 2016-12-14 Last modified: 2017-05-10 Method: X-RAY DIFFRACTION (0.9 Å) Cite: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
5GJH	Gads SH2 domain/CD28-derived peptide complex Descriptor: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28 Authors: Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. Deposit date: 2016-06-30 Release date: 2016-12-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
2MRJ	Structure of Fyn protein SH2 bound Descriptor: Tyrosine-protein kinase Fyn Authors: Huculeci, R, Buts, L, Lenaerts, T, Van Nuland, N. Deposit date: 2014-07-09 Release date: 2015-07-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 2016
2PLE	NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE Descriptor: PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF Authors: Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D. Deposit date: 1994-08-19 Release date: 1995-01-26 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell(Cambridge,Mass.), 77, 1994
4EY0	Structure of tandem SH2 domains from PLCgamma1 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-01 Release date: 2012-10-31 Last modified: 2013-06-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
5EEQ	Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor Descriptor: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION Authors: Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. Deposit date: 2015-10-23 Release date: 2016-06-15 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
2PNA	STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN Authors: Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D. Deposit date: 1992-06-30 Release date: 1994-01-31 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase. Nature, 358, 1992
4F5A	Triple mutant Src SH2 domain bound to phosphate ion Descriptor: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F59	Triple mutant Src SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
2PNB	STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN Authors: Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D. Deposit date: 1992-06-30 Release date: 1994-01-31 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase. Nature, 358, 1992

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