4WYF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wyf by Molmil](/molmil-images/mine/4wyf) | |
4WLM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wlm by Molmil](/molmil-images/mine/4wlm) | |
4WLG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wlg by Molmil](/molmil-images/mine/4wlg) | |
4WMR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wmr by Molmil](/molmil-images/mine/4wmr) | STRUCTURE OF MCL1 BOUND TO BRD inhibitor ligand 1 AT 1.7A | Descriptor: | 7-[2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl]-3-[3-(naphthalen-1-yloxy)propyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1, PYROPHOSPHATE 2-, ... | Authors: | CLIFTON, M.C, EDWARDS, T.E. | Deposit date: | 2014-10-09 | Release date: | 2015-05-06 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
|
|
4WMX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wmx by Molmil](/molmil-images/mine/4wmx) | The structure of MBP-MCL1 bound to ligand 6 at 2.0A | Descriptor: | 4-ethenyl-2-[(phenylsulfonyl)amino]benzoic acid, FORMIC ACID, MAGNESIUM ION, ... | Authors: | Clifton, M.C, Dranow, D.M. | Deposit date: | 2014-10-09 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
|
|
4WMV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wmv by Molmil](/molmil-images/mine/4wmv) | STRUCTURE OF MBP-MCL1 BOUND TO ligand 4 AT 2.4A | Descriptor: | 3-chloro-6-fluoro-1-benzothiophene-2-carboxylic acid, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Clifton, M.C, Moulin, A. | Deposit date: | 2014-10-09 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
|
|
4WQN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wqn by Molmil](/molmil-images/mine/4wqn) | Crystal structure of N6-methyladenosine RNA reader YTHDF2 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, YTH domain-containing family protein 2 | Authors: | Zhu, T, Roundtree, I.A, Wang, P, Wang, X, Wang, L, Sun, C, Tian, Y, Li, J, He, C, Xu, Y. | Deposit date: | 2014-10-22 | Release date: | 2014-11-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.121 Å) | Cite: | Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res., 24, 2014
|
|
4WRH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wrh by Molmil](/molmil-images/mine/4wrh) | AKR1C3 complexed with breakdown product of N-(tert-butyl)-2-(2-chloro-4-(((3-mercapto-5-methyl-4H-1,2,4-triazol-4-yl)amino)methyl)-6-methoxyphenoxy)acetamide | Descriptor: | 1,2-ETHANEDIOL, 2-[4-(aminomethyl)-2-chloro-6-methoxyphenoxy]-N-tert-butylacetamide, 5-methyl-4H-1,2,4-triazole-3-thiol, ... | Authors: | Squire, C.J, Flanagan, J.U, Yosaatmadja, Y. | Deposit date: | 2014-10-24 | Release date: | 2014-11-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Breakdown product of N-(tert-butyl)-2-(2-chloro-4-(((3-mercapto-5-methyl-4H-1,2,4-triazol-4-yl)amino)methyl)-6-methoxyphenoxy)acetamide trapped in active site of AKR1C3 To Be Published
|
|
4WX1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wx1 by Molmil](/molmil-images/mine/4wx1) | |
4WYG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wyg by Molmil](/molmil-images/mine/4wyg) | Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis complexed with a fragment hit | Descriptor: | 1,2-ETHANEDIOL, 1-{4-[(4-chloro-1H-pyrazol-1-yl)methyl]phenyl}methanamine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Dai, R, Finzel, B.C. | Deposit date: | 2014-11-17 | Release date: | 2015-07-08 | Last modified: | 2015-07-22 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
|
|
4WZ6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wz6 by Molmil](/molmil-images/mine/4wz6) | Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | Authors: | Byrnes, L.J, Hall, J. | Deposit date: | 2014-11-18 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. Protein Sci., 25, 2016
|
|
4X0L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x0l by Molmil](/molmil-images/mine/4x0l) | Human haptoglobin-haemoglobin complex | Descriptor: | CACODYLATE ION, GLYCEROL, Haptoglobin, ... | Authors: | Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K. | Deposit date: | 2014-11-21 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor. Elife, 3, 2014
|
|
4WLZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wlz by Molmil](/molmil-images/mine/4wlz) | |
4WMW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wmw by Molmil](/molmil-images/mine/4wmw) | The structure of MBP-MCL1 bound to ligand 5 at 1.9A | Descriptor: | 1,2-ETHANEDIOL, 2-hydroxy-5-(methylsulfanyl)benzoic acid, FORMIC ACID, ... | Authors: | Clifton, M.C, Dranow, D.M. | Deposit date: | 2014-10-09 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
|
|
4WT8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wt8 by Molmil](/molmil-images/mine/4wt8) | Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex | Descriptor: | 23S rRNA (2899-MER), 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Amunts, A, Fiedorczuk, K, Ramakrishnan, V. | Deposit date: | 2014-10-29 | Release date: | 2015-01-21 | Last modified: | 2018-07-18 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics. J.Mol.Biol., 427, 2015
|
|
4WZ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wz9 by Molmil](/molmil-images/mine/4wz9) | APN1 from Anopheles gambiae | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, AGAP004809-PA, ALA-ALA-ALA-LYS-ALA, ... | Authors: | Atkinson, S.C, Armistead, J.S, Mathias, D.K, Sandeu, M.M, Tao, D, Borhani-Dizaji, N, Morlais, I, Dinglasan, R.R, Borg, N.A. | Deposit date: | 2014-11-19 | Release date: | 2015-06-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope. Nat.Struct.Mol.Biol., 22, 2015
|
|
4YOO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yoo by Molmil](/molmil-images/mine/4yoo) | p107 pocket domain in complex with LIN52 P29A peptide | Descriptor: | LIN52 peptide, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, SULFATE ION | Authors: | Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M. | Deposit date: | 2015-03-12 | Release date: | 2015-05-13 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural mechanisms of DREAM complex assembly and regulation. Genes Dev., 29, 2015
|
|
4YJ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yj5 by Molmil](/molmil-images/mine/4yj5) | Crystal structure of PKM2 mutant | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PYRUVIC ACID, ... | Authors: | Liu, J.-S, Wu, C.-W, Wang, W.-C. | Deposit date: | 2015-03-03 | Release date: | 2016-03-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation Commun Biol, 2, 2019
|
|
4YPG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ypg by Molmil](/molmil-images/mine/4ypg) | |
4YM1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ym1 by Molmil](/molmil-images/mine/4ym1) | |
4YOQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yoq by Molmil](/molmil-images/mine/4yoq) | Crystal Structure of MutY bound to its anti-substrate | Descriptor: | A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ... | Authors: | Wang, L, Lee, S, Verdine, G.L. | Deposit date: | 2015-03-11 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase. J.Biol.Chem., 290, 2015
|
|
4YB9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yb9 by Molmil](/molmil-images/mine/4yb9) | Crystal structure of the Bovine Fructose transporter GLUT5 in an open inward-facing conformation | Descriptor: | Solute carrier family 2, facilitated glucose transporter member 5 | Authors: | Verdon, G, Kang, H.J, Iwata, S, Drew, D. | Deposit date: | 2015-02-18 | Release date: | 2015-10-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and mechanism of the mammalian fructose transporter GLUT5. Nature, 526, 2015
|
|
4YBQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ybq by Molmil](/molmil-images/mine/4ybq) | Rat GLUT5 with Fv in the outward-open form | Descriptor: | Solute carrier family 2, facilitated glucose transporter member 5, antibody Fv fragment heavy chain, ... | Authors: | Nomura, N, Shimamura, T, Iwata, S. | Deposit date: | 2015-02-19 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.27 Å) | Cite: | Structure and mechanism of the mammalian fructose transporter GLUT5 Nature, 526, 2015
|
|
4YEU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yeu by Molmil](/molmil-images/mine/4yeu) | |
4YPH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yph by Molmil](/molmil-images/mine/4yph) | Crystal Structure of MutY bound to its anti-substrate with the disulfide cross-linker reduced | Descriptor: | A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(TP*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ... | Authors: | Wang, L, Lee, S, Verdine, G.L. | Deposit date: | 2015-03-12 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase. J.Biol.Chem., 290, 2015
|
|