PDB: 37044 resultsInfo pagesStatus searchChemie searchBIRD

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2O64	Crystal structure of Pim1 with Quercetagetin Descriptor: 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 Authors: Holder, S, Zemskova, M, Zhang, C, Tabrizizad, M, Bremer, R, Neidigh, J.W, Lilly, M.B. Deposit date: 2006-12-06 Release date: 2007-02-13 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol.Cancer Ther., 6, 2007
2NSS	Nitrobenzene Modified Horse Heart Myoglobin Descriptor: Myoglobin, NITROSOBENZENE, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Copeland, D.M, West, A.H, Richter-Addo, G.B. Deposit date: 2006-11-06 Release date: 2007-11-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Nitrosoalkane and Nitrosoarene Binding to Myoglobin and Heme Models To be Published
2OH0	Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors Descriptor: (2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE, Inhibitory peptide, cAMP-dependent protein kinase, ... Authors: Stoll, V.S. Deposit date: 2007-01-09 Release date: 2007-03-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt. Bioorg.Med.Chem., 15, 2007
2OIL	Crystal structure of human RAB25 in complex with GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-25, ... Authors: Zhu, H, Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2007-01-11 Release date: 2007-01-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of human RAB25 in complex with GDP To be Published
2NXL	Structure of HIV-1 protease D25N complexed with the rt-rh analogue peptide GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA Descriptor: Analogue of RT-RH pol protease substrate peptide, PHOSPHATE ION, PROTEASE RETROPEPSIN Authors: Prabu-Jeyabalan, M, Nalivaika, E, Schiffer, C.A. Deposit date: 2006-11-17 Release date: 2007-09-18 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease Proteins, 70, 2007
2NTR	Crystal structure of Human Bace-1 bound to inhibitor Descriptor: (2R)-2-(5-{3-chloro-6-((2-methoxyethyl){[(1S,2S)-2-methylcyclopropyl]methyl}amino)-2-[methyl(methylsulfonyl)amino]pyrid in-4-yl}-1,3,4-oxadiazol-2-yl)-1-phenylpropan-2-amine, Beta-secretase 1 Authors: Munshi, S. Deposit date: 2006-11-08 Release date: 2007-11-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites. Bioorg.Med.Chem.Lett., 17, 2007
2NZA	Structure and Function Studies of Cytochrome P450 158A1 from Streptomyces coelicolor A3(2) Descriptor: Cytochrome P450 CYP158A1, PROTOPORPHYRIN IX CONTAINING FE Authors: Zhao, B, Waterman, M.R. Deposit date: 2006-11-22 Release date: 2007-07-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Different binding modes of two flaviolin substrate molecules in cytochrome P450 158A1 (CYP158A1) compared to CYP158A2. Biochemistry, 46, 2007
2NZJ	The crystal structure of REM1 in complex with GDP Descriptor: CHLORIDE ION, GTP-binding protein REM 1, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Turnbull, A.P, Papagrigoriou, E, Ugochukwu, E, Elkins, J.M, Soundararajan, M, Yang, X, Gorrec, F, Umeano, C, Salah, E, Burgess, N, Johansson, C, Berridge, G, Gileadi, O, Bray, J, Marsden, B, Watts, S, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C.H, Sundstrom, M, Doyle, D, Structural Genomics Consortium (SGC) Deposit date: 2006-11-23 Release date: 2006-12-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of REM1 in complex with GDP To be Published
2O7K	S. aureus thioredoxin Descriptor: Thioredoxin Authors: Roos, G, Garcia-Pino, A, Van Belle, K, Brosens, E, Wahni, K, Vandenbussche, G, Wyns, L, Loris, R, Messens, J. Deposit date: 2006-12-11 Release date: 2007-07-24 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin J.Mol.Biol., 368, 2007
2O7N	CD11A (LFA1) I-domain complexed with 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile Descriptor: 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile, Integrin alpha-L Authors: Sheriff, S. Deposit date: 2006-12-11 Release date: 2007-03-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold. Bioorg.Med.Chem.Lett., 17, 2007
2OHK	X-ray crystal structure of beta secretase complexed with 1-amino-isoquinoline Descriptor: Beta-secretase 1, DIMETHYL SULFOXIDE, IODIDE ION, ... Authors: Patel, S. Deposit date: 2007-01-10 Release date: 2007-03-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Application of fragment screening by X-ray crystallography to beta-Secretase. J.Med.Chem., 50, 2007
2OHU	X-ray crystal structure of beta secretase complexed with compound 8b Descriptor: Beta-secretase 1, DIMETHYL SULFOXIDE, IODIDE ION, ... Authors: Patel, S. Deposit date: 2007-01-10 Release date: 2007-03-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. J.Med.Chem., 50, 2007
2MSS	MUSASHI1 RBD2, NMR Descriptor: PROTEIN (MUSASHI1) Authors: Nagata, T, Kanno, R, Kurihara, Y, Uesugi, S, Imai, T, Sakakibara, S, Okano, H, Katahira, M. Deposit date: 1999-05-19 Release date: 2000-05-19 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Structure, backbone dynamics and interactions with RNA of the C-terminal RNA-binding domain of a mouse neural RNA-binding protein, Musashi1. J.Mol.Biol., 287, 1999
2N1K	Structure of the Third Type III Domain from Human Fibronectin Descriptor: Fibronectin Authors: Stine, J.M, Sun, Y, Armstrong, G, Briknarova, K. Deposit date: 2015-04-04 Release date: 2015-11-11 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure and Unfolding of the Third Type III Domain from Human Fibronectin. Biochemistry, 54, 2015
2N2W	Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 8.0 Descriptor: Insulin A chain, Insulin B chain Authors: Veverka, V, Hexnerova, R, Jiracek, J. Deposit date: 2015-05-15 Release date: 2016-02-03 Method: SOLUTION NMR Cite: Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
2N3H	Solution structure of DRB4 dsRBD2 (viz. DRB4(81-151)) Descriptor: Double-stranded RNA-binding protein 4 Authors: Deshmukh, M, Chiliveri, S. Deposit date: 2015-05-29 Release date: 2016-09-07 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: DRB4 dsRBD1 drives dsRNA recognition in Arabidopsis thaliana tasi/siRNA pathway. Nucleic Acids Res., 45, 2017
2MPI	Solution structure of B24G insulin Descriptor: insulin chain A, insulin chain B Authors: Yang, Y, Wickramasinghe, N.P, Hua, Q, Weiss, M.A. Deposit date: 2014-05-19 Release date: 2014-12-24 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
2MZQ	NMR structure of the RRM3 domain of Gbp2 Descriptor: Single-strand telomeric DNA-binding protein GBP2 Authors: Martinez-Lumbreras, S, Seraphin, B, Perez-Canadillas, J. Deposit date: 2015-02-23 Release date: 2015-12-02 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Gbp2 interacts with THO/TREX through a novel type of RRM domain. Nucleic Acids Res., 44, 2016
2N5A	Structures of the REDUCED state of the mutant D24A of yeast thioredoxin 1 Descriptor: Thioredoxin-1 Authors: Iqbal, A, Moraes, A.H, Valente, A.P, Almeida, F.C.L. Deposit date: 2015-07-13 Release date: 2015-10-28 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structures of the reduced and oxidized state of the mutant D24A of yeast thioredoxin 1: insights into the mechanism for the closing of the water cavity. J.Biomol.Nmr, 63, 2015
2N25	Solution structure of Miz-1 zinc finger 2 Descriptor: ZINC ION, Zinc finger and BTB domain-containing protein 17 Authors: Bedard, M, Lavigne, P. Deposit date: 2015-04-28 Release date: 2015-06-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution structure of the 13th C2H2 Zinc Finger of Miz-1. Biochem.Biophys.Res.Commun., 473, 2016
2NLW	Solution structure of the RRM domain of human eukaryotic initiation factor 3b Descriptor: Eukaryotic translation initiation factor 3 subunit 9 Authors: ElAntak, L, Tzakos, A.G, Locker, N, Lukavsky, P.J. Deposit date: 2006-10-20 Release date: 2007-02-06 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. J.Biol.Chem., 282, 2007
2MWX	The RING Domain of human Promyelocytic Leukemia Protein (PML) Descriptor: Protein PML, ZINC ION Authors: Huang, S.Y, Chang, C.F, Fan, P.J, Guntert, P, Shih, H.M, Huang, T.H. Deposit date: 2014-12-02 Release date: 2015-02-11 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The RING domain of human promyelocytic leukemia protein (PML). J.Biomol.Nmr, 61, 2015
2NNI	CYP2C8dH complexed with montelukast Descriptor: Cytochrome P450 2C8, MONTELUKAST, PALMITIC ACID, ... Authors: Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F. Deposit date: 2006-10-24 Release date: 2007-10-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283, 2008
2MPG	Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue Descriptor: Insulin A chain, Insulin B chain Authors: Kosinova, L, Jiracek, J, Zakova, L, Veverka, V. Deposit date: 2014-05-17 Release date: 2014-06-11 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. Biochemistry, 53, 2014
2MQI	human Fyn SH2 free state Descriptor: Tyrosine-protein kinase Fyn Authors: Huculeci, R, Buts, L, Lenaerts, T, VanNuland, N. Deposit date: 2014-06-20 Release date: 2015-07-29 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity. Structure, 24, 2016

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