6NQ0
| Cryo-EM structure of human TPC2 channel in the ligand-bound open state | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | Authors: | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | Deposit date: | 2019-01-18 | Release date: | 2019-03-27 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
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6NFV
| Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. | Deposit date: | 2018-12-20 | Release date: | 2019-08-07 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
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6NFU
| Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. | Deposit date: | 2018-12-20 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
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6ND0
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6N4R
| CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2 | Descriptor: | Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ... | Authors: | Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M. | Deposit date: | 2018-11-20 | Release date: | 2019-01-23 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176, 2019
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6N4Q
| CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2 | Descriptor: | Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ... | Authors: | Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M. | Deposit date: | 2018-11-20 | Release date: | 2019-01-23 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176, 2019
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6MWG
| NavAb Voltage-gated Sodium Channel, residues 1-239, with mutation T206V | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ACETATE ION, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6MWD
| NavAb Voltage-gated Sodium Channel, residues 1-239 with mutation T206S | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ACETATE ION, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.327 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6MWB
| NavAb Voltage-gated Sodium Channel, residues 1-239 with mutation T206A | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6MWA
| NavAb Voltage-gated Sodium Channel, residues 1-239 | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6MVY
| NavAb voltage-gated sodium channel, residues 1-226, crystallized in the presence of Class 1B Anti-arrhythmic drug Lidocaine | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, SULFATE ION | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-28 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.002 Å) | Cite: | Fenestrations control resting-state block of a voltage-gated sodium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6MVX
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6MVW
| NavAb voltage-gated sodium channel, I217C/F203W | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-28 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.198 Å) | Cite: | Fenestrations control resting-state block of a voltage-gated sodium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6MVV
| NavAb voltage-gated sodium channel, I217C/F203A | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-28 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Fenestrations control resting-state block of a voltage-gated sodium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6MU2
| Structure of full-length IP3R1 channel in the Apo-state | Descriptor: | Inositol 1,4,5-trisphosphate receptor type 1 | Authors: | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | Deposit date: | 2018-10-22 | Release date: | 2018-12-05 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28, 2018
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6MU1
| Structure of full-length IP3R1 channel bound with Adenophostin A | Descriptor: | Adenophostin A, Inositol 1,4,5-trisphosphate receptor type 1 | Authors: | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | Deposit date: | 2018-10-22 | Release date: | 2018-12-05 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28, 2018
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6MJ2
| Human TRPM2 ion channel in a calcium- and ADPR-bound state | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (6.36 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
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6MIZ
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6MIX
| Human TRPM2 ion channel in apo state | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
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6MIE
| Solution NMR structure of the KCNQ1 voltage-sensing domain | Descriptor: | Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Taylor, K.C, Kuenze, G, Smith, J.A, Meiler, J, McFeeters, R.L, Sanders, C.R. | Deposit date: | 2018-09-19 | Release date: | 2020-03-04 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. Elife, 9, 2020
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6MHX
| Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (2) | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
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6MHW
| Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (1) | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
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6MHV
| Structure of human TRPV3 in the presence of 2-APB in C4 symmetry | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
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6MHS
| Structure of the human TRPV3 channel in a putative sensitized conformation | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
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6MHO
| Structure of the human TRPV3 channel in the apo conformation | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
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