1S63
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![BU of 1s63 by Molmil](/molmil-images/mine/1s63) | Human protein farnesyltransferase complexed with L-778,123 and FPP | Descriptor: | 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE, FARNESYL DIPHOSPHATE, Protein farnesyltransferase beta subunit, ... | Authors: | Long, S.B, Casey, P.J, Beese, L.S. | Deposit date: | 2004-01-22 | Release date: | 2004-07-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes. Biochemistry, 43, 2004
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1SA4
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![BU of 1sa4 by Molmil](/molmil-images/mine/1sa4) | human protein farnesyltransferase complexed with FPP and R115777 | Descriptor: | 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, FARNESYL DIPHOSPHATE, Protein farnesyltransferase beta subunit, ... | Authors: | Reid, T.S, Beese, L.S. | Deposit date: | 2004-02-06 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity. Biochemistry, 43, 2004
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1TJ4
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![BU of 1tj4 by Molmil](/molmil-images/mine/1tj4) | X-Ray structure of the Sucrose-Phosphatase (SPP) from Synechocystis sp. PCC6803 in complex with sucrose | Descriptor: | MAGNESIUM ION, Sucrose-Phosphatase, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | Authors: | Fieulaine, S, Lunn, J.E, Borel, F, Ferrer, J.-L. | Deposit date: | 2004-06-03 | Release date: | 2005-06-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell. Plant Cell, 17, 2005
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1TJ5
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![BU of 1tj5 by Molmil](/molmil-images/mine/1tj5) | X-Ray structure of the Sucrose-Phosphatase (SPP) from Synechocystis sp. PCC6803 in complex with sucrose and phosphate | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, Sucrose-Phosphatase, ... | Authors: | Fieulaine, S, Lunn, J.E, Borel, F, Ferrer, J.-L. | Deposit date: | 2004-06-03 | Release date: | 2005-06-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell. Plant Cell, 17, 2005
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1TN6
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![BU of 1tn6 by Molmil](/molmil-images/mine/1tn6) | Protein Farnesyltransferase Complexed with a Rap2a Peptide Substrate and a FPP Analog at 1.8A Resolution | Descriptor: | ACETIC ACID, Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ... | Authors: | Reid, T.S, Terry, K.L, Casey, P.J, Beese, L.S. | Deposit date: | 2004-06-11 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity J.Mol.Biol., 343, 2004
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1U45
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![BU of 1u45 by Molmil](/molmil-images/mine/1u45) | 8oxoguanine at the pre-insertion site of the polymerase active site | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1U47
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![BU of 1u47 by Molmil](/molmil-images/mine/1u47) | cytosine-8-Oxoguanine base pair at the polymerase active site | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1U48
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![BU of 1u48 by Molmil](/molmil-images/mine/1u48) | Extension of a cytosine-8-oxoguanine base pair | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1U49
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![BU of 1u49 by Molmil](/molmil-images/mine/1u49) | Adenine-8oxoguanine mismatch at the polymerase active site | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1U4B
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![BU of 1u4b by Molmil](/molmil-images/mine/1u4b) | Extension of an adenine-8oxoguanine mismatch | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1UA0
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![BU of 1ua0 by Molmil](/molmil-images/mine/1ua0) | Aminofluorene DNA adduct at the pre-insertion site of a DNA polymerase | Descriptor: | 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... | Authors: | Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S. | Deposit date: | 2004-08-11 | Release date: | 2004-09-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase J.Biol.Chem., 279, 2004
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1UC2
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![BU of 1uc2 by Molmil](/molmil-images/mine/1uc2) | Hypothetical Extein Protein of PH1602 from Pyrococcus horikoshii | Descriptor: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, hypothetical protein PH1602 | Authors: | Okada, C, Maegawa, Y, Yao, M, Tanaka, I. | Deposit date: | 2003-04-08 | Release date: | 2004-05-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of an RtcB homolog protein (PH1602-extein protein) from Pyrococcus horikoshii reveals a novel fold Proteins, 63, 2006
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1V8X
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![BU of 1v8x by Molmil](/molmil-images/mine/1v8x) | Crystal Structure of the Dioxygen-bound Heme Oxygenase from Corynebacterium diphtheriae | Descriptor: | Heme oxygenase, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Unno, M, Matsui, T, Chu, G.C, Couture, M, Yoshida, T, Rousseau, D.L, Olson, J.S, Ikeda-Saito, M. | Deposit date: | 2004-01-15 | Release date: | 2004-05-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structure of the Dioxygen-bound Heme Oxygenase from Corynebacterium diphtheriae: IMPLICATIONS FOR HEME OXYGENASE FUNCTION. J.Biol.Chem., 279, 2004
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1X3W
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![BU of 1x3w by Molmil](/molmil-images/mine/1x3w) | Structure of a peptide:N-glycanase-Rad23 complex | Descriptor: | UV excision repair protein RAD23, ZINC ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... | Authors: | Lee, J.-H, Choi, J.M, Lee, C, Yi, K.J, Cho, Y. | Deposit date: | 2005-05-11 | Release date: | 2005-06-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of a peptide:N-glycanase-Rad23 complex: insight into the deglycosylation for denatured glycoproteins. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1X3Z
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![BU of 1x3z by Molmil](/molmil-images/mine/1x3z) | Structure of a peptide:N-glycanase-Rad23 complex | Descriptor: | UV excision repair protein RAD23, ZINC ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... | Authors: | Lee, J.-H, Choi, J.M, Lee, C, Yi, K.J, Cho, Y. | Deposit date: | 2005-05-11 | Release date: | 2005-06-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of a peptide:N-glycanase-Rad23 complex: insight into the deglycosylation for denatured glycoproteins. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1XC9
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![BU of 1xc9 by Molmil](/molmil-images/mine/1xc9) | Structure of a high-fidelity polymerase bound to a benzo[a]pyrene adduct that blocks replication | Descriptor: | 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, DNA polymerase I, DNA primer strand, ... | Authors: | Hsu, G.W, Huang, X, Luneva, N.P, Geacintov, N.E, Beese, L.S. | Deposit date: | 2004-09-01 | Release date: | 2004-12-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of a High Fidelity DNA Polymerase Bound to a Benzo[a]pyrene Adduct That Blocks Replication J.Biol.Chem., 280, 2005
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1XLT
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![BU of 1xlt by Molmil](/molmil-images/mine/1xlt) | Crystal structure of Transhydrogenase [(domain I)2:domain III] heterotrimer complex | Descriptor: | NAD(P) transhydrogenase subunit alpha part 1, NAD(P) transhydrogenase subunit beta, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Sundaresan, V, Chartron, J, Yamaguchi, M, Stout, C.D. | Deposit date: | 2004-09-30 | Release date: | 2005-04-05 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Conformational Diversity in NAD(H) and Transhydrogenase Nicotinamide Nucleotide Binding Domains J.Mol.Biol., 346, 2005
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1YLJ
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![BU of 1ylj by Molmil](/molmil-images/mine/1ylj) | Atomic resolution structure of CTX-M-9 beta-lactamase | Descriptor: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, beta-lactamase CTX-M-9a | Authors: | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | Deposit date: | 2005-01-19 | Release date: | 2005-04-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (0.98 Å) | Cite: | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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1YLP
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![BU of 1ylp by Molmil](/molmil-images/mine/1ylp) | Atomic resolution structure of CTX-M-27 beta-lactamase | Descriptor: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, beta-lactamase CTX-M-27 | Authors: | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | Deposit date: | 2005-01-19 | Release date: | 2005-04-19 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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1YLT
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![BU of 1ylt by Molmil](/molmil-images/mine/1ylt) | Atomic resolution structure of CTX-M-14 beta-lactamase | Descriptor: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, beta-lactamase CTX-M-14 | Authors: | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | Deposit date: | 2005-01-19 | Release date: | 2005-04-19 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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1YNP
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![BU of 1ynp by Molmil](/molmil-images/mine/1ynp) | aldo-keto reductase AKR11C1 from Bacillus halodurans (apo form) | Descriptor: | GLYCEROL, SODIUM ION, SULFATE ION, ... | Authors: | Marquardt, T, Kostrewa, D, Winkler, F.K, Li, X.D. | Deposit date: | 2005-01-25 | Release date: | 2005-12-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | High-resolution Crystal Structure of AKR11C1 from Bacillus halodurans: An NADPH-dependent 4-Hydroxy-2,3-trans-nonenal Reductase J.Mol.Biol., 354, 2005
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1YNQ
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![BU of 1ynq by Molmil](/molmil-images/mine/1ynq) | aldo-keto reductase AKR11C1 from Bacillus halodurans (holo form) | Descriptor: | GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION, ... | Authors: | Marquardt, T, Kostrewa, D, Winkler, F.K, Li, X.D. | Deposit date: | 2005-01-25 | Release date: | 2005-12-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | High-resolution Crystal Structure of AKR11C1 from Bacillus halodurans: An NADPH-dependent 4-Hydroxy-2,3-trans-nonenal Reductase J.Mol.Biol., 354, 2005
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1ZS2
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![BU of 1zs2 by Molmil](/molmil-images/mine/1zs2) | Amylosucrase Mutant E328Q in a ternary complex with sucrose and maltoheptaose | Descriptor: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, amylosucrase, ... | Authors: | Skov, L.K, Mirza, O, Sprogoe, D, van der Veen, B.A, Remaud-Simeon, M, Albenne, C, Monsan, P, Gajhede, M. | Deposit date: | 2005-05-23 | Release date: | 2006-05-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose BIOCATAL.BIOTRANSFOR., 24, 2006
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2ADD
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![BU of 2add by Molmil](/molmil-images/mine/2add) | Crystal structure of fructan 1-exohydrolase IIa from Cichorium intybus in complex with sucrose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... | Authors: | Verhaest, M, Le Roy, K, De Ranter, C.J, Van Laere, A, Van den Ende, W, Rabijns, A. | Deposit date: | 2005-07-20 | Release date: | 2006-08-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insights into the fine architecture of the active site of chicory fructan 1-exohydrolase: 1-kestose as substrate vs sucrose as inhibitor. New Phytol, 174, 2007
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2BE2
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![BU of 2be2 by Molmil](/molmil-images/mine/2be2) | Crystal structure of HIV-1 reverse transcriptase (RT) in complex with R221239 | Descriptor: | 4-(3,5-DIMETHYLPHENOXY)-5-(FURAN-2-YLMETHYLSULFANYLMETHYL)-3-IODO-6-METHYLPYRIDIN-2(1H)-ONE, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Himmel, D.M, Das, K, Clark Jr, A.D, Hughes, S.H, Benjahad, A, Oumouch, S, Guillemont, J, Coupa, S, Poncelet, A, Csoka, I, Meyer, C, Andries, K, Nguyen, C.H, Grierson, D.S, Arnold, E. | Deposit date: | 2005-10-21 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains. J.Med.Chem., 48, 2005
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