PDB: 125 resultsInfo pagesStatus searchChemie searchBIRD

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5FVE	Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobenzamide Descriptor: 3,4-difluorobenzamide, DNA POLYMERASE III SUBUNIT BETA Authors: Pandey, P, Gourinath, S. Deposit date: 2016-02-05 Release date: 2017-02-22 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Screening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization. Antibiotics (Basel), 7, 2018
3D1G	Structure of a small molecule inhibitor bound to a DNA sliding clamp Descriptor: DNA polymerase III subunit beta, [(5R)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid Authors: Georgescu, R.E, Yurieva, O, Seung-Sup, K, Kuriyan, J, Kong, X.-P, O'Donnell, M. Deposit date: 2008-05-05 Release date: 2008-07-29 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. Proc.Natl.Acad.Sci.Usa, 105, 2008
5AH4	The sliding clamp of Mycobacterium smegmatis in complex with a natural product. Descriptor: CYCLOHEXYL GRISELIMYCIN, DNA POLYMERASE III SUBUNIT BETA, SODIUM ION Authors: Lukat, P, Kling, A, Heinz, D.W, Mueller, R. Deposit date: 2015-02-04 Release date: 2015-06-03 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.313 Å) Cite: Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins. Science, 348, 2015
5G48	H.pylori Beta clamp in complex with Diflunisal Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, DNA POLYMERASE III SUBUNIT BETA Authors: Pandey, P, Gourinath, S. Deposit date: 2016-05-06 Release date: 2017-06-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Targeting the beta-clamp in Helicobacter pylori with FDA-approved drugs reveals micromolar inhibition by diflunisal. FEBS Lett., 591, 2017
8GIZ	E. coli clamp loader with open clamp Descriptor: Beta sliding clamp, DNA polymerase III subunit delta, DNA polymerase III subunit delta', ... Authors: Oakley, A.J, Xu, Z.-Q, Dixon, N.E. Deposit date: 2023-03-14 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural characterisation of the complete cycle of sliding clamp loading in E. coli To Be Published
8GIY	E. coli clamp loader with closed clamp Descriptor: Beta sliding clamp, DNA polymerase III subunit delta, DNA polymerase III subunit delta', ... Authors: Oakley, A.J, Xu, Z.-Q, Dixon, N.E. Deposit date: 2023-03-14 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural characterisation of the complete cycle of sliding clamp loading in E. coli To Be Published
8GJ1	E. coli clamp loader with open clamp on primed template DNA (form 2) Descriptor: ADENOSINE-5'-DIPHOSPHATE, Beta sliding clamp, DNA polymerase III subunit delta, ... Authors: Oakley, A.J, Xu, Z.-Q, Dixon, N.E. Deposit date: 2023-03-14 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural characterisation of the complete cycle of sliding clamp loading in E. coli To Be Published
8GJ2	E. coli clamp loader with closed clamp on primed template DNA Descriptor: ADENOSINE-5'-DIPHOSPHATE, Beta sliding clamp, DNA polymerase III subunit delta, ... Authors: Oakley, A.J, Xu, Z.-Q, Dixon, N.E. Deposit date: 2023-03-14 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Structural characterisation of the complete cycle of sliding clamp loading in E. coli To Be Published
8GJ0	E. coli clamp loader with open clamp on primed template DNA (form 1) Descriptor: ADENOSINE-5'-DIPHOSPHATE, Beta sliding clamp, DNA polymerase III subunit delta, ... Authors: Oakley, A.J, Xu, Z.-Q, Dixon, N.E. Deposit date: 2023-03-14 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural characterisation of the complete cycle of sliding clamp loading in E. coli To Be Published
4N95	E. coli sliding clamp in complex with 5-chloroindoline-2,3-dione Descriptor: 5-chloro-1H-indole-2,3-dione, CALCIUM ION, CHLORIDE ION, ... Authors: Yin, Z, Oakley, A.J. Deposit date: 2013-10-19 Release date: 2013-11-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
4N94	E. coli sliding clamp in complex with 3,4-difluorobenzamide Descriptor: 1,2-ETHANEDIOL, 3,4-difluorobenzamide, CALCIUM ION, ... Authors: Yin, Z, Oakley, A.J. Deposit date: 2013-10-19 Release date: 2013-11-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
4N98	E. coli sliding clamp in complex with 4'-fluorobiphenyl-4-carboxylic acid Descriptor: 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID, CALCIUM ION, CHLORIDE ION, ... Authors: Yin, Z, Oakley, A.J. Deposit date: 2013-10-19 Release date: 2013-11-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
6E8D	Crystal structure of the Bacillus subtilis sliding clamp-MutL complex. Descriptor: Beta sliding clamp,DNA mismatch repair protein MutL, GLYCEROL Authors: Guarne, A, Almawi, A.W. Deposit date: 2018-07-28 Release date: 2019-05-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Binding of the regulatory domain of MutL to the sliding beta-clamp is species specific. Nucleic Acids Res., 47, 2019
6E8E	Crystal structure of the Escherichia coli sliding clamp-MutL complex. Descriptor: Beta sliding clamp,DNA mismatch repair protein MutL, GLYCEROL, SULFATE ION Authors: Guarne, A, Almawi, A.W. Deposit date: 2018-07-28 Release date: 2019-05-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Binding of the regulatory domain of MutL to the sliding beta-clamp is species specific. Nucleic Acids Res., 47, 2019
4N9A	E. coli sliding clamp in complex with (R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid Descriptor: (1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid, CALCIUM ION, CHLORIDE ION, ... Authors: Yin, Z, Oakley, A.J. Deposit date: 2013-10-19 Release date: 2013-11-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
4N97	E. coli sliding clamp in complex with 5-nitroindole Descriptor: 5-nitro-1H-indole, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Yin, Z, Oakley, A.J. Deposit date: 2013-10-19 Release date: 2013-11-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
4N99	E. coli sliding clamp in complex with 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-7-carboxylic acid Descriptor: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-7-carboxylic acid, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Yin, Z, Oakley, A.J. Deposit date: 2013-10-19 Release date: 2013-11-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J.Med.Chem., 57, 2014
6FVL	DNA polymerase sliding clamp from Escherichia coli with bound P7 peptide Descriptor: Beta sliding clamp, GLYCEROL, P7 peptide, ... Authors: Martiel, I, Andre, C, Olieric, V, Guichard, G, Burnouf, D. Deposit date: 2018-03-04 Release date: 2019-04-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.975 Å) Cite: Peptide Interactions on Bacterial Sliding Clamps. Acs Infect Dis., 2019
6FVN	DNA polymerase sliding clamp from Mycobacterium tuberculosis with bound P7 peptide Descriptor: Beta sliding clamp, P7 peptide Authors: Martiel, I, Andre, C, Olieric, V, Guichard, G, Burnouf, D. Deposit date: 2018-03-04 Release date: 2019-04-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.142 Å) Cite: Peptide Interactions on Bacterial Sliding Clamps. Acs Infect Dis., 2019
6FVO	Mutant DNA polymerase sliding clamp from Mycobacterium tuberculosis with bound P7 peptide Descriptor: Beta sliding clamp, CALCIUM ION, P7 peptide Authors: Martiel, I, Andre, C, Olieric, V, Guichard, G, Burnouf, D. Deposit date: 2018-03-04 Release date: 2019-04-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.689 Å) Cite: Peptide Interactions on Bacterial Sliding Clamps. Acs Infect Dis., 2019
6FVM	Mutant DNA polymerase sliding clamp from Escherichia coli with bound P7 peptide Descriptor: Beta sliding clamp, CALCIUM ION, GLYCEROL, ... Authors: Martiel, I, Andre, C, Olieric, V, Guichard, G, Burnouf, D. Deposit date: 2018-03-04 Release date: 2019-04-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.631 Å) Cite: Peptide Interactions on Bacterial Sliding Clamps. Acs Infect Dis., 2019
6AMS	Crystal structure of the DNA polymerase III subunit beta from Pseudomonas aeruginosa Descriptor: Beta sliding clamp, PHOSPHATE ION Authors: McGrath, A.E, Oakley, A.J. Deposit date: 2017-08-11 Release date: 2017-11-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. J. Struct. Biol., 204, 2018
6AP4	Crystal structure of the DNA polymerase III subunit beta from Acinetobacter baumannii Descriptor: DNA polymerase III subunit beta, MAGNESIUM ION Authors: McGrath, A.E, Oakley, A.J. Deposit date: 2017-08-16 Release date: 2017-12-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. J. Struct. Biol., 204, 2018
3Q4K	Structure of a small peptide ligand bound to E.coli DNA sliding clamp Descriptor: DNA polymerase III subunit beta, peptide ligand Authors: Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. Deposit date: 2010-12-23 Release date: 2011-12-28 Last modified: 2013-03-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011
3Q4L	Structure of a small peptide ligand bound to E.coli DNA sliding clamp Descriptor: DNA polymerase III subunit beta, SODIUM ION, peptide ligand Authors: Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. Deposit date: 2010-12-23 Release date: 2011-12-28 Last modified: 2013-03-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J.Med.Chem., 54, 2011

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