PDB: 73628 resultsInfo pagesStatus searchChemie searchBIRD

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3BJU	Crystal Structure of tetrameric form of human lysyl-tRNA synthetase Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ... Authors: Guo, M, Yang, X.L, Schimmel, P. Deposit date: 2007-12-04 Release date: 2008-02-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Proc.Natl.Acad.Sci.Usa, 105, 2008
2CIM	Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase Descriptor: CHLORIDE ION, PLATINUM (II) ION, SERYL-TRNA SYNTHETASE, ... Authors: Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. Deposit date: 2006-03-24 Release date: 2006-06-26 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition Embo J., 25, 2006
4Q15	Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Halofuginone and AMPPNP in space group P212121 at 2.35 A Descriptor: 1,2-ETHANEDIOL, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2014-04-02 Release date: 2016-04-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. Acs Infect Dis., 3, 2017
2CXA	Crystal structure of Leucyl/phenylalanyl-tRNA protein transferase from Escherichia coli Descriptor: Leucyl/phenylalanyl-tRNA-protein transferase Authors: Kato-Murayama, M, Bessho, Y, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-06-28 Release date: 2005-12-28 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The crystal structure of leucyl/phenylalanyl-tRNA-protein transferase from Escherichia coli Protein Sci., 16, 2007
5UCM	Crystal Structure of Prolyl-tRNA Synthetase from Pseudomonas aeruginosa Descriptor: MAGNESIUM ION, Proline--tRNA ligase Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-12-22 Release date: 2017-02-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Characterization and structure determination of prolyl-tRNA synthetase from Pseudomonas aeruginosa and development as a screening platform. Protein Sci., 2019
5USF	Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor Descriptor: 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, Immunoglobulin heavy chain variable region, Tyrosyl-tRNA synthetase, ... Authors: Barros-Alvarez, X, Hol, W.G.J. Deposit date: 2017-02-13 Release date: 2017-05-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie, 138, 2017
2HKZ	Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with L-serine Descriptor: SERINE, Threonyl-tRNA synthetase Authors: Dwivedi, S, Kruparani, S.P, Sankaranarayanan, R. Deposit date: 2006-07-06 Release date: 2006-08-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea Embo J., 25, 2006
2HL1	Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with seryl-3'-aminoadenosine Descriptor: SERINE-3'-AMINOADENOSINE, Threonyl-tRNA synthetase Authors: Hussain, T, Kruparani, S.P, Pal, B, Sankaranarayanan, R. Deposit date: 2006-07-06 Release date: 2006-08-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea Embo J., 25, 2006
3IAL	Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate Descriptor: 5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, GLYCEROL, Prolyl-tRNA synthetase Authors: Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2009-07-14 Release date: 2009-08-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr.,Sect.D, 68, 2012
4JC4	Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa at 2.25 angstrom resolution Descriptor: GLYCEROL, Peptidyl-tRNA hydrolase Authors: Singh, A, Kumar, A, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Arora, A, Singh, T.P. Deposit date: 2013-02-21 Release date: 2013-04-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase Biochem.J., 463, 2014
2HL0	Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with seryl-3'-aminoadenosine Descriptor: SERINE-3'-AMINOADENOSINE, Threonyl-tRNA synthetase Authors: Hussain, T, Kruparani, S.P, Pal, B, Sankaranarayanan, R. Deposit date: 2006-07-06 Release date: 2006-08-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea Embo J., 25, 2006
2HL2	Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with an analog of seryladenylate Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Threonyl-tRNA synthetase Authors: Hussain, T, Kruparani, S.P, Pal, B, Sankaranarayanan, R. Deposit date: 2006-07-06 Release date: 2006-08-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea Embo J., 25, 2006
5V49	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1917) Descriptor: GLYCEROL, METHIONINE, Methionyl-tRNA synthetase, ... Authors: Barros-Alvarez, X, Hol, W.G.J. Deposit date: 2017-03-08 Release date: 2017-07-26 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
7F6W	Crystal structure of Saccharomyces cerevisiae lysyl-tRNA Synthetase Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine--tRNA ligase Authors: Wu, S, Li, P, Hei, Z, Zheng, L, Wang, J, Fang, P. Deposit date: 2021-06-26 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.607 Å) Cite: Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex. Cell.Mol.Life Sci., 79, 2022
3KFL	Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ... Authors: Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2009-10-27 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie, 93, 2011
4HWS	Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor Descriptor: N-{[3-(4-amino-2-chloroquinazolin-7-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION Authors: Hilgers, M.T. Deposit date: 2012-11-08 Release date: 2013-09-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56, 2013
3P0I	Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, cubic crystal form Descriptor: 4-[(2S)-2-amino-3-hydroxypropyl]phenol, Tyrosyl-tRNA synthetase Authors: Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2010-09-28 Release date: 2011-03-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3.13 Å) Cite: The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011
4HWP	Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor Descriptor: N-{[3-(4-amino-2-methylquinazolin-7-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION Authors: Hilgers, M.T. Deposit date: 2012-11-08 Release date: 2013-09-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.807 Å) Cite: Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56, 2013
4HWT	Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor Descriptor: N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, cytoplasmic, ... Authors: Hilgers, M.T. Deposit date: 2012-11-08 Release date: 2013-09-18 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56, 2013
3P0J	Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, triclinic crystal form 1 Descriptor: 4-[(2S)-2-amino-3-hydroxypropyl]phenol, SODIUM ION, Tyrosyl-tRNA synthetase Authors: Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2010-09-28 Release date: 2011-03-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.89 Å) Cite: The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011
4HWO	Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor Descriptor: N-{[3-(4-aminoquinazolin-7-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION Authors: Hilgers, M.T. Deposit date: 2012-11-08 Release date: 2013-09-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.907 Å) Cite: Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56, 2013
4HWR	Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor Descriptor: N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, Threonine--tRNA ligase, ZINC ION Authors: Hilgers, M.T. Deposit date: 2012-11-08 Release date: 2013-09-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56, 2013
3QTC	Crystal structure of the catalytic domain of MmOmeRS, an O-methyl tyrosyl-tRNA synthetase evolved from Methanosarcina mazei PylRS, complexed with O-methyl tyrosine and AMP-PNP Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, O-methyl-L-tyrosine, ... Authors: Dellas, N, Takimoto, J.K, Noel, J.P, Wang, L. Deposit date: 2011-02-22 Release date: 2011-05-25 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids. Acs Chem.Biol., 6, 2011
3P0H	Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form Descriptor: 3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase Authors: Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2010-09-28 Release date: 2011-03-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3 Å) Cite: The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011
1P4N	Crystal Structure of Weissella viridescens FemX:UDP-MurNAc-pentapeptide complex Descriptor: FemX, GLYCEROL, MAGNESIUM ION, ... Authors: Biarrotte-Sorin, S, Maillard, A, Delettre, J, Sougakoff, W, Arthur, M, Mayer, C. Deposit date: 2003-04-23 Release date: 2004-02-10 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition. Structure, 12, 2004

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