4ZT3

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1614)

Summary for 4ZT3

• Entry DOI: 10.2210/pdb4zt3/pdb
• Related: 4ZT2 4ZT4 4ZT5 4ZT6 4ZT7
• Descriptor: Methionyl-tRNA synthetase, METHIONINE, GLYCEROL, ... (7 entities in total)
• Functional Keywords: ligase, aminoacyl-trna synthetase, aars, metrs, trypanosoma brucei, protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 124306.14

Authors

Koh, C.-Y.,Hol, W.G.J. (deposition date: 2015-05-14, release date: 2016-05-04, Last modification date: 2023-09-27)

• Primary citation: Zhang, Z.,Koh, C.Y.,Ranade, R.M.,Shibata, S.,Gillespie, J.R.,Hulverson, M.A.,Huang, W.,Nguyen, J.,Pendem, N.,Gelb, M.H.,Verlinde, C.L.,Hol, W.G.,Buckner, F.S.,Fan, E.; 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.; Acs Infect Dis., 2:399-404, 2016; PubMed: 27627628; DOI: 10.1021/acsinfecdis.6b00036

Experimental method

X-RAY DIFFRACTION (2.8 Å)