4ZT3
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1614)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue MET A 801 |
| Chain | Residue |
| A | ILE248 |
| A | HOH946 |
| A | TYR249 |
| A | TYR250 |
| A | ASP287 |
| A | TRP474 |
| A | ALA477 |
| A | TYR481 |
| A | HIS523 |
| A | LYS550 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 802 |
| Chain | Residue |
| A | ARG583 |
| A | ARG601 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 804 |
| Chain | Residue |
| A | GLU392 |
| A | LYS517 |
| A | ASP518 |
| A | LEU520 |
| A | LYS521 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 805 |
| Chain | Residue |
| A | PHE370 |
| A | PRO445 |
| A | LYS521 |
| A | TYR526 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 806 |
| Chain | Residue |
| A | GLU349 |
| A | TYR405 |
| A | VAL463 |
| A | PRO464 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 807 |
| Chain | Residue |
| A | ARG271 |
| A | SER714 |
| A | PRO718 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 801 |
| Chain | Residue |
| B | ARG583 |
| B | ARG601 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 802 |
| Chain | Residue |
| B | TYR472 |
| B | TRP474 |
| B | PHE522 |
| B | 4RQ806 |
| B | HOH926 |
| B | HOH982 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 803 |
| Chain | Residue |
| B | TYR324 |
| B | ILE326 |
| B | HOH914 |
| B | HOH953 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 804 |
| Chain | Residue |
| B | TYR574 |
| B | ARG719 |
| B | LYS720 |
| B | HOH986 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 805 |
| Chain | Residue |
| B | ARG271 |
| B | VAL275 |
| B | SER714 |
| B | PRO718 |
| site_id | AD3 |
| Number of Residues | 15 |
| Details | binding site for residue 4RQ B 806 |
| Chain | Residue |
| B | ILE248 |
| B | TYR250 |
| B | ASP287 |
| B | HIS289 |
| B | GLY290 |
| B | LEU456 |
| B | TYR472 |
| B | VAL473 |
| B | TYR481 |
| B | ILE519 |
| B | PHE522 |
| B | GOL802 |
| B | HOH922 |
| B | HOH960 |
| B | HOH998 |
