4ZT7
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-1,2,3,4-tetrahydroquinolin-4-yl]-N'-(5-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1717)
Summary for 4ZT7
Entry DOI | 10.2210/pdb4zt7/pdb |
Related | 4ZT2 4ZT3 4ZT4 4ZT5 4ZT6 |
Descriptor | Methionyl-tRNA synthetase, METHIONINE, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | ligase, aminoacyl-trna synthetase, aars, metrs, trypanosoma brucei, protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 2 |
Total formula weight | 123832.54 |
Authors | Koh, C.-Y.,Hol, W.G.J. (deposition date: 2015-05-14, release date: 2016-05-04, Last modification date: 2023-09-27) |
Primary citation | Zhang, Z.,Koh, C.Y.,Ranade, R.M.,Shibata, S.,Gillespie, J.R.,Hulverson, M.A.,Huang, W.,Nguyen, J.,Pendem, N.,Gelb, M.H.,Verlinde, C.L.,Hol, W.G.,Buckner, F.S.,Fan, E. 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infect Dis., 2:399-404, 2016 Cited by PubMed: 27627628DOI: 10.1021/acsinfecdis.6b00036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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