2AA9
 
 | | EPSP synthase liganded with shikimate | | Descriptor: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 3-phosphoshikimate 1-carboxyvinyltransferase, FORMIC ACID | | Authors: | Priestman, M.A, Healy, M.L, Funke, T, Becker, A, Schonbrunn, E. | | Deposit date: | 2005-07-13 | | Release date: | 2006-02-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate.
Febs Lett., 579, 2005
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2AAZ
 | | Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate | | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | | Authors: | Finer-Moore, J.S, Anderson, A.C, O'Neil, R.H, Costi, M.P, Ferrari, S, Krucinski, J, Stroud, R.M. | | Deposit date: | 2005-07-14 | | Release date: | 2005-12-06 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
Acta Crystallogr.,Sect.D, 61, 2005
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3CGW
 | | Crystal structure of 2-phospho-(S)-lactate transferase from Methanosarcina mazei. Northeast Structural Genomics Consortium target MaR46 | | Descriptor: | LPPG:FO 2-phospho-L-lactate transferase | | Authors: | Forouhar, F, Abashidze, M, Seetharaman, J, Vorobiev, S.M, Ciao, M, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-03-06 | | Release date: | 2008-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Molecular insights into the biosynthesis of the f420 coenzyme.
J.Biol.Chem., 283, 2008
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1HZW
 | | CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE | | Descriptor: | PHOSPHATE ION, THYMIDYLATE SYNTHASE | | Authors: | Almog, R, Waddling, C.A, Maley, F, Maley, G.F, Van Roey, P. | | Deposit date: | 2001-01-26 | | Release date: | 2001-05-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Protein Sci., 10, 2001
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1I00
 | | CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE, TERNARY COMPLEX WITH DUMP AND TOMUDEX | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX | | Authors: | Almog, R.A, Waddling, C.A, Maley, F, Maley, G.F, Van Roey, P. | | Deposit date: | 2001-01-27 | | Release date: | 2001-05-09 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Protein Sci., 10, 2001
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3CP6
 | | Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor | | Descriptor: | (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), Farnesyl pyrophosphate synthetase, MAGNESIUM ION | | Authors: | Pilka, E.S, Dunford, J.E, Guo, K, Pike, A.C.W, von Delft, F, Barnett, B.L, Ebetino, F.H, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Russell, R.G.G, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2008-03-31 | | Release date: | 2008-04-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor.
To be Published
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2RB5
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2RD8
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4BIW
 | | Crystal structure of CpxAHDC (hexagonal form) | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SENSOR PROTEIN CPXA, ... | | Authors: | Mechaly, A.E, Sassoon, N, Betton, J.M, Alzari, P.M. | | Deposit date: | 2013-04-13 | | Release date: | 2014-02-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation.
Plos Biol., 12, 2014
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2RAH
 | | Human FDPS synthase in complex with novel inhibitor | | Descriptor: | Farnesyl pyrophosphate synthetase, MAGNESIUM ION, SULFATE ION, ... | | Authors: | Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M. | | Deposit date: | 2007-09-15 | | Release date: | 2007-09-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human FDPS synthase in complex with novel inhibitor
To be Published
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1IXQ
 | | Enzyme-Phosphate2 Complex of Pyridoxine 5'-Phosphate synthase | | Descriptor: | PHOSPHATE ION, Pyridoxine 5'-phosphate Synthase | | Authors: | Garrido-Franco, M, Laber, B, Huber, R, Clausen, T. | | Deposit date: | 2002-06-28 | | Release date: | 2003-02-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis
J.MOL.BIOL., 321, 2002
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4BIV
 | | Crystal structure of CpxAHDC (trigonal form) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, SENSOR PROTEIN CPXA | | Authors: | Mechaly, A.E, Sassoon, N, Betton, J.M, Alzari, P.M. | | Deposit date: | 2013-04-13 | | Release date: | 2014-02-12 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation.
Plos Biol., 12, 2014
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4JZB
 | | Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with 1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)-3-PHENYLPYRIDINIUM, IPP and Ca2+ | | Descriptor: | 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, ... | | Authors: | Aripirala, S, Amzel, L.M, Gabelli, S. | | Deposit date: | 2013-04-02 | | Release date: | 2014-02-12 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.
Acta Crystallogr.,Sect.D, 70, 2014
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2RAR
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2BTD
 | | Crystal structure of DhaL from E. coli | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PTS-DEPENDENT DIHYDROXYACETONE KINASE | | Authors: | Oberholzer, A.E, Schneider, P, Bachler, C, Baumann, U, Erni, B. | | Deposit date: | 2005-05-27 | | Release date: | 2006-06-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of the Nucleotide-Binding Subunit Dhal of the Escherichia Coli Dihydroxyacetone Kinase.
J.Mol.Biol., 359, 2006
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2BNP
 | | Lipidic cubic phase grown reaction centre from Rhodobacter sphaeroides, ground state | | Descriptor: | 2-T-BUTYLAMINO-4-ETHYLAMINO-6-METHYLTHIO-S-TRIAZINE, BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, ... | | Authors: | Katona, G, Snijder, A, Gourdon, P, Andreasson, U, Hansson, O, Andreasson, L.E, Neutze, R. | | Deposit date: | 2005-03-31 | | Release date: | 2005-05-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Conformational Regulation of Charge Recombination Reactions in a Photosynthetic Bacterial Reaction Centre
Nat.Struct.Mol.Biol., 12, 2005
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1IJD
 | | Crystallographic Structure of the LH3 Complex from Rhodopseudomonas acidophila strain 7050 | | Descriptor: | BACTERIOCHLOROPHYLL A, LIGHT-HARVESTING PROTEIN B-800/820, ALPHA CHAIN, ... | | Authors: | McLuskey, K, Prince, S.M, Cogdell, R.J, Isaacs, N.W. | | Deposit date: | 2001-04-25 | | Release date: | 2001-10-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The crystallographic structure of the B800-820 LH3 light-harvesting complex from the purple bacteria Rhodopseudomonas acidophila strain 7050.
Biochemistry, 40, 2001
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1RYW
 | | C115S MurA liganded with reaction products | | Descriptor: | GLYCEROL, PHOSPHATE ION, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, ... | | Authors: | Eschenburg, S, Schonbrunn, E. | | Deposit date: | 2003-12-22 | | Release date: | 2004-11-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Evidence That the Fosfomycin Target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA) Is Essential for Product Release.
J.Biol.Chem., 280, 2005
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4BIA
 | | Crystal structure of SCP2 thiolase from Trypanosoma brucei: The C337A mutant. | | Descriptor: | 3-KETOACYL-COA THIOLASE, PUTATIVE | | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | | Deposit date: | 2013-04-10 | | Release date: | 2013-08-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop.
Biochem.J., 455, 2013
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4BIY
 | | Crystal structure of CpxAHDC (monoclinic form 2) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SENSOR PROTEIN CPXA, SULFATE ION | | Authors: | Mechaly, A.E, Sassoon, N, Betton, J.M, Alzari, P.M. | | Deposit date: | 2013-04-13 | | Release date: | 2014-02-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation.
Plos Biol., 12, 2014
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2GNU
 | | The crystallization of reaction center from Rhodobacter sphaeroides occurs via a new route | | Descriptor: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | | Authors: | Wadsten, P, Woehri, A.B, Snijder, A, Katona, G, Gardiner, A.T, Cogdell, R.J, Neutze, R, Engstroem, S. | | Deposit date: | 2006-04-11 | | Release date: | 2006-11-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Lipidic sponge phase crystallization of membrane proteins
J.Mol.Biol., 364, 2006
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2RAV
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2H5U
 | | Crystal structure of laccase from Cerrena maxima at 1.9A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Lyashenko, A.V, Gabdoulkhakov, A.G, Zaitsev, V.N, Lamzin, V.S, Lindley, P.F, Bento, I, Betzel, C, Zhukhlistova, N.E, Zhukova, Y.N, Mikhailov, A.M. | | Deposit date: | 2006-05-27 | | Release date: | 2007-05-29 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Purification, crystallization and preliminary X-ray study of the fungal laccase from Cerrena maxima
Acta Crystallogr.,Sect.F, 62, 2006
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1S3H
 | | Propionibacterium shermanii transcarboxylase 5S subunit A59T | | Descriptor: | COBALT (II) ION, transcarboxylase 5S subunit | | Authors: | Hall, P.R, Zheng, R, Antony, L, Pusztai-Carey, M, Carey, P.R, Yee, V.C. | | Deposit date: | 2004-01-13 | | Release date: | 2004-09-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit.
Embo J., 23, 2004
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2REF
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