2ZCY
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![BU of 2zcy by Molmil](/molmil-images/mine/2zcy) | yeast 20S proteasome:syringolin A-complex | Descriptor: | (2S)-2-[[(2S)-1-[[(5S,8S,9E)-2,7-dioxo-5-propan-2-yl-1,6-diazacyclododeca-3,9-dien-8-yl]amino]-3-methyl-1-oxo-butan-2-yl]carbamoylamino]-3-methyl-butanoic acid, Proteasome component C1, Proteasome component C11, ... | Authors: | Groll, M, Dudler, R, Kaiser, M. | Deposit date: | 2007-11-15 | Release date: | 2008-04-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism Nature, 452, 2008
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2ZHU
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![BU of 2zhu by Molmil](/molmil-images/mine/2zhu) | Crystal structure of BACE1 at pH 5.0 | Descriptor: | Beta-secretase 1 | Authors: | Shimizu, H, Nukina, N. | Deposit date: | 2008-02-08 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production Mol.Cell.Biol., 28, 2008
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2J4A
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2ZHS
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![BU of 2zhs by Molmil](/molmil-images/mine/2zhs) | Crystal structure of BACE1 at pH 4.0 | Descriptor: | Beta-secretase 1 | Authors: | Shimizu, H, Nukina, N. | Deposit date: | 2008-02-08 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production Mol.Cell.Biol., 28, 2008
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2ZJ0
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![BU of 2zj0 by Molmil](/molmil-images/mine/2zj0) | Crystal structure of Mycobacterium tuberculosis S-Adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 2-fluoroadenosine | Descriptor: | 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Reddy, M.C.M, Gokulan, K, Shetty, N.D, Owen, J.L, Ioerger, T.R, Sacchettini, J.C. | Deposit date: | 2008-02-29 | Release date: | 2008-09-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Sci., 17, 2008
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2ZK4
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![BU of 2zk4 by Molmil](/molmil-images/mine/2zk4) | Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-oxo-eicosatetraenoic acid | Descriptor: | (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Waku, T, Shiraki, T, Oyama, T, Fujimoto, Y, Morikawa, K. | Deposit date: | 2008-03-12 | Release date: | 2009-02-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids J.Mol.Biol., 385, 2009
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2SFA
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![BU of 2sfa by Molmil](/molmil-images/mine/2sfa) | SERINE PROTEINASE FROM STREPTOMYCES FRADIAE ATCC 14544 | Descriptor: | SERINE PROTEINASE | Authors: | Kitadokoro, K, Tsuzuki, H. | Deposit date: | 1994-04-25 | Release date: | 1996-06-20 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Purification, characterization, primary structure, crystallization and preliminary crystallographic study of a serine proteinase from Streptomyces fradiae ATCC 14544. Eur.J.Biochem., 220, 1994
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2ZK0
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![BU of 2zk0 by Molmil](/molmil-images/mine/2zk0) | Human peroxisome proliferator-activated receptor gamma ligand binding domain | Descriptor: | Peroxisome proliferator-activated receptor gamma | Authors: | Waku, T, Shiraki, T, Oyama, T, Fujimoto, Y, Morikawa, K. | Deposit date: | 2008-03-12 | Release date: | 2009-02-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids J.Mol.Biol., 385, 2009
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2ZKS
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![BU of 2zks by Molmil](/molmil-images/mine/2zks) | Structural insights into the proteolytic machinery of apoptosis-inducing Granzyme M | Descriptor: | Granzyme M, SULFATE ION, hGzmM inhibitor | Authors: | Wu, L.F, Wang, L, Hua, G.Q, Liu, K, Yang, X, Zhai, Y.J, Sun, F, Fan, Z.S. | Deposit date: | 2008-03-28 | Release date: | 2009-03-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M J.Immunol., 183, 2009
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2ZM3
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![BU of 2zm3 by Molmil](/molmil-images/mine/2zm3) | Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor | Descriptor: | (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione, Insulin-like growth factor 1 receptor | Authors: | Xu, W, Mayer, S.C, Boschelli, F, Johnson, M, Dwyer, B. | Deposit date: | 2008-04-10 | Release date: | 2008-06-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment Bioorg.Med.Chem.Lett., 18, 2008
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2ZN9
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![BU of 2zn9 by Molmil](/molmil-images/mine/2zn9) | Crystal structure of Ca2+-bound form of des3-20ALG-2 | Descriptor: | CALCIUM ION, DODECAETHYLENE GLYCOL, NONAETHYLENE GLYCOL, ... | Authors: | Suzuki, H, Kawasaki, M, Inuzuka, T, Kakiuchi, T, Shibata, H, Wakatsuki, S, Maki, M. | Deposit date: | 2008-04-22 | Release date: | 2008-09-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Ca(2+)-Dependent Formation of ALG-2/Alix Peptide Complex: Ca(2+)/EF3-Driven Arginine Switch Mechanism Structure, 16, 2008
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2RG3
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![BU of 2rg3 by Molmil](/molmil-images/mine/2rg3) | Covalent complex structure of elastase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Leukocyte elastase | Authors: | Huang, W, Yamamoto, Y. | Deposit date: | 2007-10-02 | Release date: | 2008-07-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives. J.Med.Chem., 51, 2008
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2RDF
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3I77
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![BU of 3i77 by Molmil](/molmil-images/mine/3i77) | 35/99/170-loops of FXa in SGT | Descriptor: | ACETATE ION, CALCIUM ION, SULFATE ION, ... | Authors: | Page, M.J, Di Cera, E. | Deposit date: | 2009-07-08 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Combinatorial Enzyme Design Probes Allostery and Cooperativity in the Trypsin Fold. J.Mol.Biol., 399, 2010
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2Z6H
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![BU of 2z6h by Molmil](/molmil-images/mine/2z6h) | Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain | Descriptor: | Catenin beta-1 | Authors: | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | Deposit date: | 2007-08-01 | Release date: | 2008-02-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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2J0Y
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![BU of 2j0y by Molmil](/molmil-images/mine/2j0y) | L-ficolin complexed to b-1,3-D-glucan | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Garlatti, V, Gaboriaud, C. | Deposit date: | 2006-08-08 | Release date: | 2007-01-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J., 26, 2007
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2RBM
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2J3O
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![BU of 2j3o by Molmil](/molmil-images/mine/2j3o) | L-ficolin complexed to N-acetyl-D-glucosamine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Garlatti, V, Gaboriaud, C. | Deposit date: | 2006-08-22 | Release date: | 2007-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J., 26, 2007
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2ZE1
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![BU of 2ze1 by Molmil](/molmil-images/mine/2ze1) | X-ray structure of Bace-1 in complex with compound 6g | Descriptor: | 3-bromo-N-[4-[1-(2-carbamimidamido-2-oxo-ethyl)-5-phenyl-pyrrol-2-yl]phenyl]benzamide, Beta-secretase 1 | Authors: | Chopra, R, Olland, A. | Deposit date: | 2007-12-05 | Release date: | 2008-12-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets. Bioorg.Med.Chem.Lett., 18, 2008
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2Z8K
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2ZFT
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![BU of 2zft by Molmil](/molmil-images/mine/2zft) | Exploring trypsin S3 pocket | Descriptor: | (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ... | Authors: | Brandt, T, Baum, B, Heine, A, Klebe, G. | Deposit date: | 2008-01-11 | Release date: | 2009-01-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties J.Mol.Biol., 405, 2011
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3IN7
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2ZJJ
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![BU of 2zjj by Molmil](/molmil-images/mine/2zjj) | |
2ZRQ
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![BU of 2zrq by Molmil](/molmil-images/mine/2zrq) | Crystal structure of S324A-subtilisin | Descriptor: | CALCIUM ION, Tk-subtilisin | Authors: | Tanaka, S, Takeuchi, Y, Matsumura, H, Koga, Y, Takano, K, Kanaya, S. | Deposit date: | 2008-08-28 | Release date: | 2009-03-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of Tk-subtilisin folded without propeptide: requirement of propeptide for acceleration of folding Febs Lett., 582, 2008
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2ZU6
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![BU of 2zu6 by Molmil](/molmil-images/mine/2zu6) | crystal structure of the eIF4A-PDCD4 complex | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... | Authors: | Cho, Y, Chang, J.H, Sohn, S.Y. | Deposit date: | 2008-10-13 | Release date: | 2009-02-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the eIF4A-PDCD4 complex Proc.Natl.Acad.Sci.Usa, 106, 2009
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