2RG3

Covalent complex structure of elastase

Summary for 2RG3

Entry DOI	10.2210/pdb2rg3/pdb
Related	1ppg
Descriptor	Leukocyte elastase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	elastase, complex, covalent, disease mutation, glycoprotein, hydrolase, protease, serine protease, zymogen
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	24334.09
Authors	Huang, W.,Yamamoto, Y. (deposition date: 2007-10-02, release date: 2008-07-01, Last modification date: 2020-07-29)
Primary citation	Huang, W.,Yamamoto, Y.,Li, Y.,Dou, D.,Alliston, K.R.,Hanzlik, R.P.,Williams, T.D.,Groutas, W.C. X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives. J.Med.Chem., 51:2003-2008, 2008 Cited by PubMed: 18318470 DOI: 10.1021/jm700966p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation