7Z6F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z6f by Molmil](/molmil-images/mine/7z6f) | |
7SKW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7skw by Molmil](/molmil-images/mine/7skw) | Ab initio structure of triclinic lysozyme from electron-counted MicroED data | Descriptor: | Lysozyme C, NITRATE ION | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Hattne, J, Gonen, T. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Last modified: | 2022-06-22 | Method: | ELECTRON CRYSTALLOGRAPHY (0.87 Å) | Cite: | Ab initio phasing macromolecular structures using electron-counted MicroED data. Nat.Methods, 19, 2022
|
|
4Q11
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q11 by Molmil](/molmil-images/mine/4q11) | Crystal structure of Proteus mirabilis transcriptional regulator protein Crl at 1.95A resolution | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Sigma factor-binding protein Crl | Authors: | Norel, F, Mayer, C, Saul, F.A, Haouz, A. | Deposit date: | 2014-04-02 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/ sigma S subunit of RNA polymerase. Biochem.J., 463, 2014
|
|
7SJQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sjq by Molmil](/molmil-images/mine/7sjq) | |
7Z68
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z68 by Molmil](/molmil-images/mine/7z68) | Pseudomonas aeruginosa Elastase in complex with a Thiol based inhibitor (R-and S-configured) | Descriptor: | (2~{R})-~{N}-[4-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanylphenyl]-3-phenyl-2-sulfanyl-propanamide, CALCIUM ION, GLYCEROL, ... | Authors: | Klein, A, Hirsch, A. | Deposit date: | 2022-03-11 | Release date: | 2023-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB To Be Published
|
|
7Z8Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z8z by Molmil](/molmil-images/mine/7z8z) | |
7SKX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7skx by Molmil](/molmil-images/mine/7skx) | Ab initio structure of proteinase K from electron-counted MicroED data | Descriptor: | 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CALCIUM ION, Proteinase K | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Hattne, J, Gonen, T. | Deposit date: | 2021-10-21 | Release date: | 2022-06-08 | Last modified: | 2022-06-22 | Method: | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | Cite: | Ab initio phasing macromolecular structures using electron-counted MicroED data. Nat.Methods, 19, 2022
|
|
7SG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sg5 by Molmil](/molmil-images/mine/7sg5) | Structure of PfCSP peptide 21 with antibody CIS43_Var2 | Descriptor: | CIS43_Var2 Fab Heavy chain, CIS43_Var2 Fab Light chain, GLYCEROL, ... | Authors: | Tripathi, P, Kwong, P.D. | Deposit date: | 2021-10-05 | Release date: | 2022-06-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Highly protective antimalarial antibodies via precision library generation and yeast display screening. J.Exp.Med., 219, 2022
|
|
7SG6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sg6 by Molmil](/molmil-images/mine/7sg6) | Structure of PfCSP peptide 21 with antibody CIS43_Var10 | Descriptor: | CIS43_Var10 Fab Heavy chain, CIS43_Var10 Fab Light chain, GLYCEROL, ... | Authors: | Tripathi, P, Kwong, P.D. | Deposit date: | 2021-10-05 | Release date: | 2022-06-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Highly protective antimalarial antibodies via precision library generation and yeast display screening. J.Exp.Med., 219, 2022
|
|
7ZAO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zao by Molmil](/molmil-images/mine/7zao) | Structure of BPP43_05035 of Brachyspira pilosicoli | Descriptor: | MAGNESIUM ION, Sialidase (Neuraminidase) family protein-like protein | Authors: | Rajan, A, Gallego, P, Pelaseyed, T. | Deposit date: | 2022-03-22 | Release date: | 2023-10-11 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection Biorxiv, 2024
|
|
7RWW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rww by Molmil](/molmil-images/mine/7rww) | Crystal structure of a Zn-bound RIDC1 variant | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Kakkis, A, Golub, E. | Deposit date: | 2021-08-20 | Release date: | 2022-06-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Redox- and metal-directed structural diversification in designed metalloprotein assemblies. Chem.Commun.(Camb.), 58, 2022
|
|
7ZET
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zet by Molmil](/molmil-images/mine/7zet) | Crystal structure of human Clusterin, crystal form I | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Clusterin, ... | Authors: | Yuste-Checa, P, Bracher, A, Hartl, F.U. | Deposit date: | 2022-03-31 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of human Clusterin, crystal form I To be published
|
|
7S6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7s6h by Molmil](/molmil-images/mine/7s6h) | Human PARP1 deltaV687-E688 bound to NAD+ analog EB-47 and to a DNA double strand break. | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, DNA (5'-D(*CP*GP*AP*CP*G)-3'), ... | Authors: | Rouleau-Turcotte, E, Pascal, J.M. | Deposit date: | 2021-09-14 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol.Cell, 82, 2022
|
|
7RWU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rwu by Molmil](/molmil-images/mine/7rwu) | |
7S81
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7s81 by Molmil](/molmil-images/mine/7s81) | Structure of human PARP1 domains (Zn1, Zn3, WGR, HD) bound to a DNA double strand break. | Descriptor: | DNA (5'-D(*AP*TP*GP*CP*GP*GP*CP*CP*GP*CP*AP*T)-3'), Poly [ADP-ribose] polymerase 1, ZINC ION | Authors: | Rouleau-Turcotte, E, Pascal, J.M. | Deposit date: | 2021-09-17 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol.Cell, 82, 2022
|
|
7ZEU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zeu by Molmil](/molmil-images/mine/7zeu) | |
7RWN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rwn by Molmil](/molmil-images/mine/7rwn) | Crystal Structure of BPTF bromodomain in complex with 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one | Descriptor: | 1,2-ETHANEDIOL, 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF | Authors: | Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. | Deposit date: | 2021-08-20 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021
|
|
7RUQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ruq by Molmil](/molmil-images/mine/7ruq) | Structure of the human GIGYF1-TNRC6C complex | Descriptor: | GRB10-interacting GYF protein 1, Trinucleotide repeat-containing gene 6C protein | Authors: | Sobti, M, Mead, B.J, Igreja, C, Stewart, A.G, Christie, M. | Deposit date: | 2021-08-18 | Release date: | 2022-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Molecular basis for GIGYF-TNRC6 complex assembly. Rna, 29, 2023
|
|
7RV5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rv5 by Molmil](/molmil-images/mine/7rv5) | |
7SKU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sku by Molmil](/molmil-images/mine/7sku) | Nipah virus matrix protein in complex with PI(4,5)P2 | Descriptor: | Matrix protein, SULFATE ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Norris, M.J, Saphire, E.O. | Deposit date: | 2021-10-21 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.117 Å) | Cite: | Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization. Sci Adv, 8, 2022
|
|
7SKS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sks by Molmil](/molmil-images/mine/7sks) | |
7SMD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7smd by Molmil](/molmil-images/mine/7smd) | p107 pocket domain complexed with EID1 peptide | Descriptor: | EP300-interacting inhibitor of differentiation 1, Retinoblastoma-like protein 1, SULFATE ION | Authors: | Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. | Deposit date: | 2021-10-25 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
|
|
7RWE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rwe by Molmil](/molmil-images/mine/7rwe) | Crystal structure of CDK2 liganded with compound GPHR787 | Descriptor: | 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid, Cyclin-dependent kinase 2 | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-08-19 | Release date: | 2022-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J.Med.Chem., 66, 2023
|
|
7S6M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7s6m by Molmil](/molmil-images/mine/7s6m) | |
7YPR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ypr by Molmil](/molmil-images/mine/7ypr) | Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1. | Descriptor: | COPPER (II) ION, POTASSIUM ION, Superoxide dismutase [Cu-Zn], ... | Authors: | Sim, K.-S, Fukuda, Y, Inoue, T. | Deposit date: | 2022-08-04 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1. Acta Crystallogr.,Sect.F, 79, 2023
|
|