7RWW
Crystal structure of a Zn-bound RIDC1 variant
Summary for 7RWW
Entry DOI | 10.2210/pdb7rww/pdb |
Descriptor | Soluble cytochrome b562, ZINC ION, HEME C, ... (7 entities in total) |
Functional Keywords | metal binding protein |
Biological source | Escherichia coli |
Total number of polymer chains | 4 |
Total formula weight | 50140.51 |
Authors | Kakkis, A.,Golub, E. (deposition date: 2021-08-20, release date: 2022-06-29, Last modification date: 2023-10-25) |
Primary citation | Kakkis, A.,Golub, E.,Choi, T.S.,Tezcan, F.A. Redox- and metal-directed structural diversification in designed metalloprotein assemblies. Chem.Commun.(Camb.), 58:6958-6961, 2022 Cited by PubMed Abstract: Herein we describe a designed protein building block whose self-assembly behaviour is dually gated by the redox state of disulphide bonds and the identity of exogenous metal ions. This protein construct is shown - through extensive structural and biophysical characterization - to access five distinct oligomeric states, exemplifying how the complex interplay between hydrophobic, metal-ligand, and reversible covalent interactions could be harnessed to obtain multiple, responsive protein architectures from a single building block. PubMed: 35642584DOI: 10.1039/d2cc02440c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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