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7RWW

Crystal structure of a Zn-bound RIDC1 variant

Summary for 7RWW
Entry DOI10.2210/pdb7rww/pdb
DescriptorSoluble cytochrome b562, ZINC ION, HEME C, ... (7 entities in total)
Functional Keywordsmetal binding protein
Biological sourceEscherichia coli
Total number of polymer chains4
Total formula weight50140.51
Authors
Kakkis, A.,Golub, E. (deposition date: 2021-08-20, release date: 2022-06-29, Last modification date: 2023-10-25)
Primary citationKakkis, A.,Golub, E.,Choi, T.S.,Tezcan, F.A.
Redox- and metal-directed structural diversification in designed metalloprotein assemblies.
Chem.Commun.(Camb.), 58:6958-6961, 2022
Cited by
PubMed Abstract: Herein we describe a designed protein building block whose self-assembly behaviour is dually gated by the redox state of disulphide bonds and the identity of exogenous metal ions. This protein construct is shown - through extensive structural and biophysical characterization - to access five distinct oligomeric states, exemplifying how the complex interplay between hydrophobic, metal-ligand, and reversible covalent interactions could be harnessed to obtain multiple, responsive protein architectures from a single building block.
PubMed: 35642584
DOI: 10.1039/d2cc02440c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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